Association of interleukin-8 gene variability with recurrent aphthous stomatitis

SLEZÁKOVÁ, Simona, Petra BOŘILOVÁ LINHARTOVÁ, Denisa KAVŘÍKOVÁ, Jiřina BÁRTOVÁ, Jitka PETANOVÁ, Pavel KUKLÍNEK, Antonín FASSMANN and Lydie IZAKOVIČOVÁ HOLLÁ. Association of interleukin-8 gene variability with recurrent aphthous stomatitis. In The Biomania Student Scientific Meeting 2017, Brno. 2017. ISBN 978-80-210-8737-8.

Basic information

• Original name: Association of interleukin-8 gene variability with recurrent aphthous stomatitis
• Authors: SLEZÁKOVÁ, Simona (203 Czech Republic, belonging to the institution), Petra BOŘILOVÁ LINHARTOVÁ (203 Czech Republic, belonging to the institution), Denisa KAVŘÍKOVÁ (203 Czech Republic, belonging to the institution), Jiřina BÁRTOVÁ (203 Czech Republic), Jitka PETANOVÁ (203 Czech Republic), Pavel KUKLÍNEK (203 Czech Republic, belonging to the institution), Antonín FASSMANN (203 Czech Republic, belonging to the institution) and Lydie IZAKOVIČOVÁ HOLLÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: The Biomania Student Scientific Meeting 2017, Brno, 2017.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30208 Dentistry, oral surgery and medicine
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/17:00100727
• Organization unit: Faculty of Medicine
• ISBN: 978-80-210-8737-8
• Keywords in English: interleukin-8; association studies; polymorphism; recurrent aphthous stomatitis

Abstract

Objectives: Variability in the interleukin-8 gene (IL-8), encoding a proinflammatory chemokine, was recently associated with Behçet's syndrome, disease with recurrent oral ulcers as one of its symptoms. The aim of this study was to analyse four single nucleotide polymorphisms (SNPs) in IL-8 and its receptor 2 (CXCR2) in patients with recurrent aphthous stomatitis (RAS) and healthy controls. Methods: Totally, 238 subjects were enrolled in this case-control study: 64 patients with RAS and 174 healthy controls were genotyped for SNPs in IL-8 (-251A/T, +396T/G, +781C/T) and CXCR2 (+1208C/T) by a method based on PCR using 5´ nuclease TaqMan assays. Results: The allele and genotype frequencies of studied polymorphisms between RAS patients and healthy controls were similar, with the exception of statistically significant differences in IL-8 +781 TT vs. CC+CT genotype frequencies between both groups. However, IL-8 A(-251)/G(+396)/C(+781) haplotype was significantly more frequent in patients with RAS (P<0.02; OR=4.2; 95% CI=1.3-13.8) than in healthy controls. Conclusions: Our study indicates that the IL-8 gene variability may affect susceptibility to RAS in the Czech population.

Links

• GB14-37368G, research and development project: Name: Centrum orofaciálního vývoje a regenerace

Investor: Czech Science Foundation

• MUNI/A/0948/2016, interní kód MU: Name: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba

Investor: Masaryk University, Category A

• NV15-29336A, research and development project: Name: Změny imunologické reaktivity u pacientů s recidivujícími aftami