Black Phosphorus Nanoparticles Potentiate the Anticancer Effect
of Oxaliplatin in Ovarian Cancer Cell Line

J 2017

Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line

FOJTŮ, Michaela, Xinyi CHIA, Zdeněk SOFER, Michal MASAŘÍK, Martin PUMERA et. al.

Základní údaje

Originální název

Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line

Autoři

FOJTŮ, Michaela (203 Česká republika, domácí), Xinyi CHIA (702 Singapur), Zdeněk SOFER (203 Česká republika), Michal MASAŘÍK (203 Česká republika, garant, domácí) a Martin PUMERA (702 Singapur)

Vydání

Advanced Functional Materials, Wrinheim, Wiley-VCH Verlag, 2017, 1616-301X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 13.325

Kód RIV

RIV/00216224:14110/17:00095042

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/adfm.201701955

UT WoS

000412319400006

Klíčová slova anglicky

black phosphorus; drug delivery; nanoparticles ovarian; cancer oxaliplatin

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 17:41, Soňa Böhmová

Anotace

V originále

During the past few years, growing attention has been paid to black phosphorus (BP) and its unique optical, electrical, and catalytic properties. Furthermore, BP has proven to be biocompatible and biodegradable; qualities that present new opportunities for its utilization in the field of life sciences. However, despite all its suitable properties and applicability, its utilization in biomedicine is still in its infancy. This study reports on the synthesis of black phosphorus nanoparticles (BP NPs) and exploration of thier applicability in targeted drug delivery. BP NPs are loaded with platinum agents—cisplatin and oxaliplatin—and subjected to in vitro evaluation of targeted drug delivery. The BP NPs are not only able to load the investigated platinum derivatives on their surfaces, but also to transfer the therapeutic cargo to target specific tissue and to combine their effect with oxaliplatin, which leads to further potentiation of the anticancer effect.

Návaznosti

GA16-05961S, projekt VaV

Název: Pokročilé nosiče platinových léčiv

Investor: Grantová agentura ČR, Pokročilé nosiče platinových léčiv

MUNI/A/1355/2016, interní kód MU

Název: Kardiovaskulární systém očima molekulární fyziologie

Investor: Masarykova univerzita, Kardiovaskulární systém očima molekulární fyziologie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/24/LF/2016, interní kód MU

Název: LF - Příspěvek IP 2016

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2016

Citovat

FOJTŮ, Michaela, Xinyi CHIA, Zdeněk SOFER, Michal MASAŘÍK a Martin PUMERA. Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line. Advanced Functional Materials. Wrinheim: Wiley-VCH Verlag, 2017, roč. 27, č. 36, s. 1-7. ISSN 1616-301X. Dostupné z: https://dx.doi.org/10.1002/adfm.201701955.

@article{1391650,
   author = {Fojtů, Michaela and Chia, Xinyi and Sofer, Zdeněk and Masařík, Michal and Pumera, Martin},
   article_location = {Wrinheim},
   article_number = {36},
   doi = {http://dx.doi.org/10.1002/adfm.201701955},
   keywords = {black phosphorus; drug delivery; nanoparticles ovarian; cancer oxaliplatin},
   language = {eng},
   issn = {1616-301X},
   journal = {Advanced Functional Materials},
   title = {Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line},
   volume = {27},
   year = {2017}
}

TY  - JOUR
ID  - 1391650
AU  - Fojtů, Michaela - Chia, Xinyi - Sofer, Zdeněk - Masařík, Michal - Pumera, Martin
PY  - 2017
TI  - Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line
JF  - Advanced Functional Materials
VL  - 27
IS  - 36
SP  - 1-7
EP  - 1-7
PB  - Wiley-VCH Verlag
SN  - 1616301X
KW  - black phosphorus
KW  - drug delivery
KW  - nanoparticles ovarian
KW  - cancer oxaliplatin
N2  - During the past few years, growing attention has been paid to black phosphorus (BP) and its unique optical, electrical, and catalytic properties. Furthermore, BP has proven to be biocompatible and biodegradable; qualities that present new opportunities for its utilization in the field of life sciences. However, despite all its suitable properties and applicability, its utilization in biomedicine is still in its infancy. This study reports on the synthesis of black phosphorus nanoparticles (BP NPs) and exploration of thier applicability in targeted drug delivery. BP NPs are loaded with platinum agents—cisplatin and oxaliplatin—and subjected to in vitro evaluation of targeted drug delivery. The BP NPs are not only able to load the investigated platinum derivatives on their surfaces, but also to transfer the therapeutic cargo to target specific tissue and to combine their effect with oxaliplatin, which leads to further potentiation of the anticancer effect.
ER  -

FOJTŮ, Michaela, Xinyi CHIA, Zdeněk SOFER, Michal MASAŘÍK a Martin PUMERA. Black Phosphorus Nanoparticles Potentiate the Anticancer Effect of Oxaliplatin in Ovarian Cancer Cell Line. \textit{Advanced Functional Materials}. Wrinheim: Wiley-VCH Verlag, 2017, roč.~27, č.~36, s.~1-7. ISSN~1616-301X. Dostupné z: https://dx.doi.org/10.1002/adfm.201701955.

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