HYLSE, Ondřej, Lukáš MAIER, Roman KUČERA, Tomáš PEREČKO, Aneta SVOBODOVÁ, Lukáš KUBALA, Kamil PARUCH a Jakub ŠVENDA. A Concise Synthesis of Forskolin. Angewandte Chemie International Edition. Německo: Verlag Chemie, 2017, roč. 2017, č. 56, s. 12586-12589. ISSN 1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.201706809. |
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@article{1392287, author = {Hylse, Ondřej and Maier, Lukáš and Kučera, Roman and Perečko, Tomáš and Svobodová, Aneta and Kubala, Lukáš and Paruch, Kamil and Švenda, Jakub}, article_location = {Německo}, article_number = {56}, doi = {http://dx.doi.org/10.1002/anie.201706809}, keywords = {adenylyl cyclases; forskolin; natural product synthesis; structural analogues}, language = {eng}, issn = {1433-7851}, journal = {Angewandte Chemie International Edition}, title = {A Concise Synthesis of Forskolin}, volume = {2017}, year = {2017} }
TY - JOUR ID - 1392287 AU - Hylse, Ondřej - Maier, Lukáš - Kučera, Roman - Perečko, Tomáš - Svobodová, Aneta - Kubala, Lukáš - Paruch, Kamil - Švenda, Jakub PY - 2017 TI - A Concise Synthesis of Forskolin JF - Angewandte Chemie International Edition VL - 2017 IS - 56 SP - 12586-12589 EP - 12586-12589 PB - Verlag Chemie SN - 14337851 KW - adenylyl cyclases KW - forskolin KW - natural product synthesis KW - structural analogues N2 - A 24-step synthesis of (:)-forskolin is presented, which delivered hundred milligram quantities of this complex diterpene in one pass. Transformations key to our approach include: a) a strategic allylic transposition, b) stepwise assembly of a sterically encumbered isoxazole ring, and c) citric acidmodified Upjohn dihydroxylation of a resilient tetrasubstituted olefin. The developed route has exciting potential for the preparation of new forskolin analogues inaccessible by semisynthesis. ER -
HYLSE, Ondřej, Lukáš MAIER, Roman KUČERA, Tomáš PEREČKO, Aneta SVOBODOVÁ, Lukáš KUBALA, Kamil PARUCH a Jakub ŠVENDA. A Concise Synthesis of Forskolin. \textit{Angewandte Chemie International Edition}. Německo: Verlag Chemie, 2017, roč.~2017, č.~56, s.~12586-12589. ISSN~1433-7851. Dostupné z: https://dx.doi.org/10.1002/anie.201706809.
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