VEČEŘA, Josef, Eva BÁRTOVÁ, Jana KREJČÍ, Soňa LEGARTOVÁ, Denisa KOMŮRKOVÁ, Jana RUDÁ, Tibor ŠTARK, Eva DRAŽANOVÁ, Tomáš KAŠPÁREK, Alexandra ŠULCOVÁ, Frank J. DEKKER, Wiktor SZYMANSKI, Christian SEISER, Georg WEITZER, Raphael MECHOULAM, Vincenzo MICALE and Stanislav KOZUBEK. HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals. Journal of cellular physiology, United States: Wiley-Liss, 2018, vol. 233, No 1, p. 530-548. ISSN 0021-9541. doi:10.1002/jcp.25914.
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Basic information
Original name HDAC1 and HDAC3 underlie dynamic H3K9 acetylation during embryonic neurogenesis and in schizophrenia-like animals
Authors VEČEŘA, Josef (203 Czech Republic, belonging to the institution), Eva BÁRTOVÁ (203 Czech Republic, guarantor), Jana KREJČÍ (203 Czech Republic), Soňa LEGARTOVÁ (703 Slovakia), Denisa KOMŮRKOVÁ (203 Czech Republic), Jana RUDÁ (203 Czech Republic, belonging to the institution), Tibor ŠTARK (703 Slovakia, belonging to the institution), Eva DRAŽANOVÁ (203 Czech Republic, belonging to the institution), Tomáš KAŠPÁREK (203 Czech Republic, belonging to the institution), Alexandra ŠULCOVÁ (203 Czech Republic, belonging to the institution), Frank J. DEKKER (528 Netherlands), Wiktor SZYMANSKI (528 Netherlands), Christian SEISER (40 Austria), Georg WEITZER (40 Austria), Raphael MECHOULAM (376 Israel), Vincenzo MICALE (380 Italy, belonging to the institution) and Stanislav KOZUBEK (203 Czech Republic, belonging to the institution).
Edition Journal of cellular physiology, United States, Wiley-Liss, 2018, 0021-9541.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.522
RIV identification code RIV/00216224:14110/18:00100736
Organization unit Faculty of Medicine
UT WoS 000411829600046
Keywords in English acetylome; H3K9 acetylation; HDACs; mouse neurogenesis; schizophrenia
Tags 14110516, EL OK, podil, rivok
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavla Foltynová, Ph.D., učo 106624. Changed: 4/3/2019 15:48.
Although histone acetylation is one of the most widely studied epigenetic modifications, there is still a lack of information regarding how the acetylome is regulated during brain development and pathophysiological processes. We demonstrate that the embryonic brain (E15) is characterized by an increase in H3K9 acetylation as well as decreases in the levels of HDAC1 and HDAC3. Moreover, experimental induction of H3K9 hyperacetylation led to the overexpression of NCAM in the embryonic cortex and depletion of Sox2 in the subventricular ependyma, which mimicked the differentiation processes. Inducing differentiation in HDAC1-deficient mouse ESCs resulted in early H3K9 deacetylation, Sox2 downregulation, and enhanced astrogliogenesis, whereas neuro-differentiation was almost suppressed. Neuro-differentiation of (wt) ESCs was characterized by H3K9 hyperacetylation that was associated with HDAC1 and HDAC3 depletion. Conversely, the hippocampi of schizophrenia-like animals showed H3K9 deacetylation that was regulated by an increase in both HDAC1 and HDAC3. The hippocampi of schizophrenia-like brains that were treated with the cannabinoid receptor-1 inverse antagonist AM251 expressed H3K9ac at the level observed in normal brains. Together, the results indicate that co-regulation of H3K9ac by HDAC1 and HDAC3 is important to both embryonic brain development and neuro-differentiation as well as the pathophysiology of a schizophrenia-like phenotype.
GBP302/12/G157, research and development projectName: Dynamika a organizace chromosomů během buněčného cyklu a při diferenciaci v normě a patologii
Investor: Czech Science Foundation, Projects to promote excellence in basic research
GJ15-13443Y, research and development projectName: Úloha hypoxií indukovaného faktoru 1 alfa ve vývoji populace neurálních kmenových buněk myši
Investor: Czech Science Foundation, Junior projects
LQ1601, research and development projectName: CEITEC 2020 (Acronym: CEITEC2020)
Investor: Ministry of Education, Youth and Sports of the CR, National Feasibility Programme II
Investor: South-Moravian Region, SoMoPro, Incoming grants
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