Arterial spin labelling detects posterior cortical
hypoperfusion in non-demented patients with Parkinson's disease

J 2017

Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease

SYRIMI, Zoe Joanna, Lubomír VOJTÍŠEK, Ilona ELIÁŠOVÁ, Jana VÍŠKOVÁ, Alena SVÁTKOVÁ et. al.

Základní údaje

Originální název

Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease

Autoři

SYRIMI, Zoe Joanna (826 Velká Británie a Severní Irsko, domácí), Lubomír VOJTÍŠEK (203 Česká republika, domácí), Ilona ELIÁŠOVÁ (203 Česká republika, domácí), Jana VÍŠKOVÁ (203 Česká republika, domácí), Alena SVÁTKOVÁ (703 Slovensko, domácí), Jiří VANÍČEK (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Journal of Neural Transmission, Wien, SPRINGER WIEN, 2017, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.779

Kód RIV

RIV/00216224:14110/17:00095668

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00702-017-1703-1

UT WoS

000399891600004

Klíčová slova anglicky

Parkinson's disease; Arterial spin labelling; Perfusion; Cognitive performance

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 3. 2018 15:55, Soňa Böhmová

Anotace

V originále

While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years +/- 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years +/- 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-33854A, projekt VaV

Název: Efekt intenzivní tanečně-pohybové intervence na kognitivní funkce a změny mozkové plasticity zdravých seniorů a pacientů s mírnou kognitivní poruchou

Citovat

SYRIMI, Zoe Joanna, Lubomír VOJTÍŠEK, Ilona ELIÁŠOVÁ, Jana VÍŠKOVÁ, Alena SVÁTKOVÁ, Jiří VANÍČEK a Irena REKTOROVÁ. Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease. Journal of Neural Transmission. Wien: SPRINGER WIEN, 2017, roč. 124, č. 5, s. 551-557. ISSN 0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-017-1703-1.

@article{1393550,
   author = {Syrimi, Zoe Joanna and Vojtíšek, Lubomír and Eliášová, Ilona and Víšková, Jana and Svátková, Alena and Vaníček, Jiří and Rektorová, Irena},
   article_location = {Wien},
   article_number = {5},
   doi = {http://dx.doi.org/10.1007/s00702-017-1703-1},
   keywords = {Parkinson's disease; Arterial spin labelling; Perfusion; Cognitive performance},
   language = {eng},
   issn = {0300-9564},
   journal = {Journal of Neural Transmission},
   title = {Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease},
   volume = {124},
   year = {2017}
}

TY  - JOUR
ID  - 1393550
AU  - Syrimi, Zoe Joanna - Vojtíšek, Lubomír - Eliášová, Ilona - Víšková, Jana - Svátková, Alena - Vaníček, Jiří - Rektorová, Irena
PY  - 2017
TI  - Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease
JF  - Journal of Neural Transmission
VL  - 124
IS  - 5
SP  - 551-557
EP  - 551-557
PB  - SPRINGER WIEN
SN  - 03009564
KW  - Parkinson's disease
KW  - Arterial spin labelling
KW  - Perfusion
KW  - Cognitive performance
N2  - While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years +/- 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years +/- 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.
ER  -

SYRIMI, Zoe Joanna, Lubomír VOJTÍŠEK, Ilona ELIÁŠOVÁ, Jana VÍŠKOVÁ, Alena SVÁTKOVÁ, Jiří VANÍČEK a Irena REKTOROVÁ. Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease. \textit{Journal of Neural Transmission}. Wien: SPRINGER WIEN, 2017, roč.~124, č.~5, s.~551-557. ISSN~0300-9564. Dostupné z: https://dx.doi.org/10.1007/s00702-017-1703-1.

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