Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease

SYRIMI, Zoe Joanna, Lubomír VOJTÍŠEK, Ilona ELIÁŠOVÁ, Jana VÍŠKOVÁ, Alena SVÁTKOVÁ, Jiří VANÍČEK and Irena REKTOROVÁ. Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease (Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson’s disease). Journal of Neural Transmission. Wien: SPRINGER WIEN, 2017, vol. 124, No 5, p. 551-557. ISSN 0300-9564. Available from: https://dx.doi.org/10.1007/s00702-017-1703-1.

Basic information

• Original name: Arterial spin labelling detects posterior cortical hypoperfusion in non-demented patients with Parkinson's disease
• Authors: SYRIMI, Zoe Joanna (826 United Kingdom of Great Britain and Northern Ireland, belonging to the institution), Lubomír VOJTÍŠEK (203 Czech Republic, belonging to the institution), Ilona ELIÁŠOVÁ (203 Czech Republic, belonging to the institution), Jana VÍŠKOVÁ (203 Czech Republic, belonging to the institution), Alena SVÁTKOVÁ (703 Slovakia, belonging to the institution), Jiří VANÍČEK (203 Czech Republic, belonging to the institution) and Irena REKTOROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Journal of Neural Transmission, Wien, SPRINGER WIEN, 2017, 0300-9564.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30103 Neurosciences
• Country of publisher: Austria
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.779
• RIV identification code: RIV/00216224:14110/17:00095668
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1007/s00702-017-1703-1
• UT WoS: 000399891600004
• Keywords in English: Parkinson's disease; Arterial spin labelling; Perfusion; Cognitive performance
• Tags: EL OK, podil
• Tags: International impact, Reviewed

Abstract

While previous studies suggested that perfusion abnormalities in Parkinson's disease (PD) are driven by dementia, our study aimed to identify perfusion underpinning of cognitive alteration in non-demented PD patients. Cerebral blood flow was measured using arterial spin labelling (ASL) in 28 PD patients (age 65 years +/- 9.9 SD) and 16 age-matched healthy controls (HC) (age 65 years +/- 7.8 SD), who also underwent neurological and cognitive testing. The 3D pseudocontinuous ASL and T2-weighted scans from 22 PD patients and 16 HC were analysed in a voxel-wise manner using SPM8 software. Associations between the ASL values in volumes of interest (VOIs) and behavioural and cognitive measures were assessed by Spearman correlation analysis. Posterior cortical hypoperfusion was found in PD patients compared to HC in the left supramarginal gyrus/superior temporal gyrus (VOI1) and left posterior cingulate/precuneus (VOI2). Positive correlation was revealed between perfusion in the VOI2 and Addenbrooke's Cognitive Examination Revised (ACE-R) scores after filtering out the effect of age, levodopa equivalent dose (LED), and total intracranial volume (TIV) (R = 0.51, p = 0.04). Conversely, negative correlation between VOI1 and ACE-R was detected (R = -0.62, p = 0.01) after regressing out the effects of motor impairment, age, LED, and TIV. In non-demented subjects with PD, blood flow abnormalities in precuneus/posterior cingulate were linked to the level of motor impairment and global cognitive performance. Oppositely, perfusion abnormalities in supramarginal gyrus might serve as a compensatory mechanism for brain degeneration and decreased cognitive performance.

Links

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• NV15-33854A, research and development project: Name: Efekt intenzivní tanečně-pohybové intervence na kognitivní funkce a změny mozkové plasticity zdravých seniorů a pacientů s mírnou kognitivní poruchou