Anticancer Activity of Artemisinin and its Derivatives

J 2017

Anticancer Activity of Artemisinin and its Derivatives

SLEZÁKOVÁ, Silvia a Jana RUDÁ

Základní údaje

Originální název

Anticancer Activity of Artemisinin and its Derivatives

Název česky

Protinádorová aktivita artemisininu a jeho derivátů

Autoři

SLEZÁKOVÁ, Silvia (703 Slovensko, domácí) a Jana RUDÁ (203 Česká republika, garant, domácí)

Vydání

Anticancer Research, Athens, International Institute of Anticancer Research, 2017, 0250-7005

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Řecko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.865

Kód RIV

RIV/00216224:14110/17:00098045

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.21873/anticanres.12046

UT WoS

000416143900010

Klíčová slova anglicky

Artemisinin; anticancer activity; Artesunate; dihydroartemisinin; review

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 16:37, Soňa Böhmová

Anotace

V originále

Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. Recent studies have documented the potential anticancer effect of artemisinin and its derivatives (ARTs). This review summarizes results of preclinical studies, documenting mechanisms of anticancer actions of ARTs and clinical studies focused mainly on efficacy, safety and dose-ranging of ARTs as anticancer chemotherapeutics. The main mechanisms of action of ARTs is the production of reactive oxygen species, inhibition of cell cycle in G0/G1 phase, induction of apoptosis and inhibition of angiogenesis. Safety studies have shown no evident toxicity and low incidence of adverse effects. ARTs potential to inhibit growth of solid tumours suggests their application in a neoadjuvant therapy. Dihydroartemisinin and artesunate exhibit chemosensitising effects in vivo in breast, lung, pancreas and glioma cancer cells, proposing the use of ARTs also in combination anticancer therapy.

Návaznosti

MUNI/A/1063/2016, interní kód MU

Název: Experimentální a translační farmakologický výzkum a vývoj

Investor: Masarykova univerzita, Experimentální a translační farmakologický výzkum a vývoj, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

SLEZÁKOVÁ, Silvia a Jana RUDÁ. Anticancer Activity of Artemisinin and its Derivatives. Anticancer Research. Athens: International Institute of Anticancer Research, 2017, roč. 37, č. 11, s. 5995-6003. ISSN 0250-7005. Dostupné z: https://dx.doi.org/10.21873/anticanres.12046.

@article{1393588,
   author = {Slezáková, Silvia and Rudá, Jana},
   article_location = {Athens},
   article_number = {11},
   doi = {http://dx.doi.org/10.21873/anticanres.12046},
   keywords = {Artemisinin; anticancer activity; Artesunate; dihydroartemisinin; review},
   language = {eng},
   issn = {0250-7005},
   journal = {Anticancer Research},
   title = {Anticancer Activity of Artemisinin and its Derivatives},
   volume = {37},
   year = {2017}
}

TY  - JOUR
ID  - 1393588
AU  - Slezáková, Silvia - Rudá, Jana
PY  - 2017
TI  - Anticancer Activity of Artemisinin and its Derivatives
JF  - Anticancer Research
VL  - 37
IS  - 11
SP  - 5995-6003
EP  - 5995-6003
PB  - International Institute of Anticancer Research
SN  - 02507005
KW  - Artemisinin
KW  - anticancer activity
KW  - Artesunate
KW  - dihydroartemisinin
KW  - review
N2  - Artemisinin is an extract from the plant Artemisia annua. With its semi-synthetic derivatives, they form a group of well-known and efficacious antimalarial drugs. Recent studies have documented the potential anticancer effect of artemisinin and its derivatives (ARTs). This review summarizes results of preclinical studies, documenting mechanisms of anticancer actions of ARTs and clinical studies focused mainly on efficacy, safety and dose-ranging of ARTs as anticancer chemotherapeutics. The main mechanisms of action of ARTs is the production of reactive oxygen species, inhibition of cell cycle in G0/G1 phase, induction of apoptosis and inhibition of angiogenesis. Safety studies have shown no evident toxicity and low incidence of adverse effects. ARTs potential to inhibit growth of solid tumours suggests their application in a neoadjuvant therapy. Dihydroartemisinin and artesunate exhibit chemosensitising effects in vivo in breast, lung, pancreas and glioma cancer cells, proposing the use of ARTs also in combination anticancer therapy.
ER  -

SLEZÁKOVÁ, Silvia a Jana RUDÁ. Anticancer Activity of Artemisinin and its Derivatives. \textit{Anticancer Research}. Athens: International Institute of Anticancer Research, 2017, roč.~37, č.~11, s.~5995-6003. ISSN~0250-7005. Dostupné z: https://dx.doi.org/10.21873/anticanres.12046.

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