NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ a Zdeněk GLATZ. In-depth insight into the methods of plasma protein-drug interaction studies: comparison of capillary electrophoresis-frontal analysis, isothermal titration calorimetry, circular dichroism and equilibrium dialysis. Electrophoresis. Weinheim: WILEY-VCH Verlag GmbH & Co. KGaA, 2018, roč. 39, č. 4, s. 581-589. ISSN 0173-0835. Dostupné z: https://dx.doi.org/10.1002/elps.201700325. |
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@article{1393974, author = {Nevídalová, Hana and Michalcová, Lenka and Glatz, Zdeněk}, article_location = {Weinheim}, article_number = {4}, doi = {http://dx.doi.org/10.1002/elps.201700325}, keywords = {Capillary electrophoresis-frontal analysis; Circular dichroism; Equilibrium dialysis; Isothermal titration calorimetry; Plasma protein-drug interaction}, language = {eng}, issn = {0173-0835}, journal = {Electrophoresis}, title = {In-depth insight into the methods of plasma protein-drug interaction studies: comparison of capillary electrophoresis-frontal analysis, isothermal titration calorimetry, circular dichroism and equilibrium dialysis}, url = {http://dx.doi.org/10.1002/elps.201700325}, volume = {39}, year = {2018} }
TY - JOUR ID - 1393974 AU - Nevídalová, Hana - Michalcová, Lenka - Glatz, Zdeněk PY - 2018 TI - In-depth insight into the methods of plasma protein-drug interaction studies: comparison of capillary electrophoresis-frontal analysis, isothermal titration calorimetry, circular dichroism and equilibrium dialysis JF - Electrophoresis VL - 39 IS - 4 SP - 581-589 EP - 581-589 PB - WILEY-VCH Verlag GmbH & Co. KGaA SN - 01730835 KW - Capillary electrophoresis-frontal analysis KW - Circular dichroism KW - Equilibrium dialysis KW - Isothermal titration calorimetry KW - Plasma protein-drug interaction UR - http://dx.doi.org/10.1002/elps.201700325 N2 - A comprehensive comparison of the four methods typically used for determining the binding parameters is presented in this study with respect to the above demand. Capillary electrophoresis-frontal analysis, isothermal titration calorimetry, circular dichroism and equilibrium dialysis were used to study the affinity of human serum albumin for diclofenac and lidocaine. These model drugs were chosen due to their different physico-chemical properties and different binding sites on the albumin molecule, also resulting in different binding strength. The binding parameters estimated under the conditions as similar as possible were comparable among all these approaches as well as to the literature values. Besides this, the comparison of the results and especially other considerations demonstrated the benefits and drawbacks of the selected methods, with capillary electrophoresis-frontal analysis being the best candidate for such studies. ER -
NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ a Zdeněk GLATZ. In-depth insight into the methods of plasma protein-drug interaction studies: comparison of capillary electrophoresis-frontal analysis, isothermal titration calorimetry, circular dichroism and equilibrium dialysis. \textit{Electrophoresis}. Weinheim: WILEY-VCH Verlag GmbH \&{} Co. KGaA, 2018, roč.~39, č.~4, s.~581-589. ISSN~0173-0835. Dostupné z: https://dx.doi.org/10.1002/elps.201700325.
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