J 2017

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

KADAŇKA, Zdeněk, Blanka ADAMOVÁ, Miloš KEŘKOVSKÝ, Zdeněk KADAŇKA, Ladislav DUŠEK et. al.

Základní údaje

Originální název

Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression

Autoři

KADAŇKA, Zdeněk (203 Česká republika, garant), Blanka ADAMOVÁ (203 Česká republika, domácí), Miloš KEŘKOVSKÝ (203 Česká republika), Zdeněk KADAŇKA (203 Česká republika), Ladislav DUŠEK (203 Česká republika, domácí), Barbora JUROVÁ (203 Česká republika), Eva VLČKOVÁ (203 Česká republika, domácí) a Josef BEDNAŘÍK (203 Česká republika, domácí)

Vydání

Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2017, 2162-3279

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.219

Kód RIV

RIV/00216224:14110/17:00095669

Organizační jednotka

Lékařská fakulta

UT WoS

000411368500027

Klíčová slova anglicky

cervical radiculopathy; degenerative cervical myelopathy; magnetic resonance imaging; nonmyelopathic degenerative cervical cord compression; predictive model

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 15. 3. 2018 15:54, Soňa Böhmová

Anotace

V originále

Objectives: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). Material and Methods: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59years, range 40-79years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2years (median duration 3years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry. Results: Clinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run-time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross-sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross-sectional area (CSA)70.1mm(2), and compression ratio (CR)0.4 were the only independent significant predictors for progression into symptomatic myelopathy. Conclusions: In addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.

Návaznosti

NT13449, projekt VaV
Název: Spondylogenní komprese krční míchy - prevalence, diagnostika a prognóza