2017
Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression
KADAŇKA, Zdeněk, Blanka ADAMOVÁ, Miloš KEŘKOVSKÝ, Zdeněk KADAŇKA, Ladislav DUŠEK et. al.Základní údaje
Originální název
Predictors of symptomatic myelopathy in degenerative cervical spinal cord compression
Autoři
KADAŇKA, Zdeněk (203 Česká republika, garant), Blanka ADAMOVÁ (203 Česká republika, domácí), Miloš KEŘKOVSKÝ (203 Česká republika), Zdeněk KADAŇKA (203 Česká republika), Ladislav DUŠEK (203 Česká republika, domácí), Barbora JUROVÁ (203 Česká republika), Eva VLČKOVÁ (203 Česká republika, domácí) a Josef BEDNAŘÍK (203 Česká republika, domácí)
Vydání
Brain and Behavior, Hoboken, John Wiley and Sons Inc. 2017, 2162-3279
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30103 Neurosciences
Stát vydavatele
Spojené státy
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 2.219
Kód RIV
RIV/00216224:14110/17:00095669
Organizační jednotka
Lékařská fakulta
UT WoS
000411368500027
Klíčová slova anglicky
cervical radiculopathy; degenerative cervical myelopathy; magnetic resonance imaging; nonmyelopathic degenerative cervical cord compression; predictive model
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 15. 3. 2018 15:54, Soňa Böhmová
Anotace
V originále
Objectives: To update a previously established list of predictors for neurological cervical cord dysfunction in nonmyelopathic degenerative cervical cord compression (NMDCCC). Material and Methods: A prospective observational follow-up study was performed in a cohort of 112 consecutive NMDCCC subjects (55 women and 57 men; median age 59years, range 40-79years), either asymptomatic (40 subjects) or presenting with cervical radiculopathy or cervical pain (72 subjects), who had completed a follow-up of at least 2years (median duration 3years). Development of clinical signs of degenerative cervical myelopathy (DCM) as the main outcome was monitored and correlated with a large number of demographic, clinical, electrophysiological, and MRI parameters including diffusion tensor imaging characteristics (DTI) established at entry. Results: Clinical evidence of the first signs and symptoms of DCM were found in 15 patients (13.4%). Development of DCM was associated with several parameters, including the clinical (radiculopathy, prolonged gait and run-time), electrophysiological (SEP, MEP and EMG signs of cervical cord dysfunction), and MRI (anteroposterior diameter of the cervical cord and cervical canal, cross-sectional area, compression ratio, type of compression, T2 hyperintensity). DTI parameters showed no significant predictive power. Multivariate analysis showed that radiculopathy, cross-sectional area (CSA)70.1mm(2), and compression ratio (CR)0.4 were the only independent significant predictors for progression into symptomatic myelopathy. Conclusions: In addition to previously described independent predictors of DCM development (radiculopathy and electrophysiological dysfunction of cervical cord), MRI parameters, namely CSA and CR, should also be considered as significant predictors for development of DCM.
Návaznosti
NT13449, projekt VaV |
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