Hedgehog pathway overexpression in pancreatic cancer is
abrogated by new-generation taxoid SB-T-1216

J 2017

Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216

MOHELNIKOVA-DUCHONOVA, B., M. KOCIK, B. DUCHONOVA, V. BRYNYCHOVA, M. OLIVERIUS et. al.

Základní údaje

Originální název

Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216

Autoři

MOHELNIKOVA-DUCHONOVA, B. (203 Česká republika), M. KOCIK (203 Česká republika), B. DUCHONOVA (203 Česká republika), V. BRYNYCHOVA (203 Česká republika), M. OLIVERIUS (203 Česká republika), Jan HLAVSA (203 Česká republika, garant, domácí), E. HONSOVA (203 Česká republika), Jan MAZANEC (203 Česká republika, domácí), Zdeněk KALA (203 Česká republika, domácí), I. OJIMA (840 Spojené státy), D.J. HUGHES (372 Irsko), J.E. DOHERTY (826 Velká Británie a Severní Irsko), H.A. MURRAY (826 Velká Británie a Severní Irsko), M.A. CROCKARD (826 Velká Británie a Severní Irsko), R. LEMSTROVA (203 Česká republika) a P. SOUCEK (203 Česká republika)

Vydání

PHARMACOGENOMICS JOURNAL, LONDON, NATURE PUBLISHING GROUP, 2017, 1470-269X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10603 Genetics and heredity

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.812

Kód RIV

RIV/00216224:14110/17:00098092

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1038/tpj.2016.55

UT WoS

000411849200008

Klíčová slova anglicky

pancreatic cancer

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 16:09, Soňa Böhmová

Anotace

V originále

The Hedgehog pathway is one of the major driver pathways in pancreatic ductal adenocarcinoma. This study investigated prognostic importance of Hedgehog signaling pathway in pancreatic cancer patients who underwent a radical resection. Tumors and adjacent non-neoplastic pancreatic tissues were obtained from 45 patients with histologically verified pancreatic cancer. The effect of experimental taxane chemotherapy on the expression of Hedgehog pathway was evaluated in vivo using a mouse xenograft model prepared using pancreatic cancer cell line Paca-44. Mice were treated by experimental Stony Brook Taxane SB-T-1216. The transcript profile of 34 Hedgehog pathway genes in patients and xenografts was assessed using quantitative PCR. The Hedgehog pathway was strongly overexpressed in pancreatic tumors and upregulation of SHH, IHH, HHAT and PTCH1 was associated with a trend toward decreased patient survival. No association of Hedgehog pathway expression with KRAS mutation status was found in tumors. Sonic hedgehog ligand was overexpressed, but all other downstream genes were downregulated by SB-T-1216 treatment in vivo. Suppression of HH pathway expression in vivo by taxane-based chemotherapy suggests a new mechanism of action for treatment of this aggressive

Citovat

MOHELNIKOVA-DUCHONOVA, B., M. KOCIK, B. DUCHONOVA, V. BRYNYCHOVA, M. OLIVERIUS, Jan HLAVSA, E. HONSOVA, Jan MAZANEC, Zdeněk KALA, I. OJIMA, D.J. HUGHES, J.E. DOHERTY, H.A. MURRAY, M.A. CROCKARD, R. LEMSTROVA a P. SOUCEK. Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216. PHARMACOGENOMICS JOURNAL. LONDON: NATURE PUBLISHING GROUP, 2017, roč. 17, č. 5, s. 452-460. ISSN 1470-269X. Dostupné z: https://dx.doi.org/10.1038/tpj.2016.55.

@article{1394046,
   author = {MohelnikovaandDuchonova, B. and Kocik, M. and Duchonova, B. and Brynychova, V. and Oliverius, M. and Hlavsa, Jan and Honsova, E. and Mazanec, Jan and Kala, Zdeněk and Ojima, I. and Hughes, D.J. and Doherty, J.E. and Murray, H.A. and Crockard, M.A. and Lemstrova, R. and Soucek, P.},
   article_location = {LONDON},
   article_number = {5},
   doi = {http://dx.doi.org/10.1038/tpj.2016.55},
   keywords = {pancreatic cancer},
   language = {eng},
   issn = {1470-269X},
   journal = {PHARMACOGENOMICS JOURNAL},
   title = {Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216},
   volume = {17},
   year = {2017}
}

TY  - JOUR
ID  - 1394046
AU  - Mohelnikova-Duchonova, B. - Kocik, M. - Duchonova, B. - Brynychova, V. - Oliverius, M. - Hlavsa, Jan - Honsova, E. - Mazanec, Jan - Kala, Zdeněk - Ojima, I. - Hughes, D.J. - Doherty, J.E. - Murray, H.A. - Crockard, M.A. - Lemstrova, R. - Soucek, P.
PY  - 2017
TI  - Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216
JF  - PHARMACOGENOMICS JOURNAL
VL  - 17
IS  - 5
SP  - 452-460
EP  - 452-460
PB  - NATURE PUBLISHING GROUP
SN  - 1470269X
KW  - pancreatic cancer
N2  - The Hedgehog pathway is one of the major driver pathways in pancreatic ductal adenocarcinoma. This study investigated prognostic importance of Hedgehog signaling pathway in pancreatic cancer patients who underwent a radical resection. Tumors and adjacent non-neoplastic pancreatic tissues were obtained from 45 patients with histologically verified pancreatic cancer. The effect of experimental taxane chemotherapy on the expression of Hedgehog pathway was evaluated in vivo using a mouse xenograft model prepared using pancreatic cancer cell line Paca-44. Mice were treated by experimental Stony Brook Taxane SB-T-1216. The transcript profile of 34 Hedgehog pathway genes in patients and xenografts was assessed using quantitative PCR. The Hedgehog pathway was strongly overexpressed in pancreatic tumors and upregulation of SHH, IHH, HHAT and PTCH1 was associated with a trend toward decreased patient survival. No association of Hedgehog pathway expression with KRAS mutation status was found in tumors. Sonic hedgehog ligand was overexpressed, but all other downstream genes were downregulated by SB-T-1216 treatment in vivo. Suppression of HH pathway expression in vivo by taxane-based chemotherapy suggests a new mechanism of action for treatment of this aggressive
ER  -

MOHELNIKOVA-DUCHONOVA, B., M. KOCIK, B. DUCHONOVA, V. BRYNYCHOVA, M. OLIVERIUS, Jan HLAVSA, E. HONSOVA, Jan MAZANEC, Zdeněk KALA, I. OJIMA, D.J. HUGHES, J.E. DOHERTY, H.A. MURRAY, M.A. CROCKARD, R. LEMSTROVA a P. SOUCEK. Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216. \textit{PHARMACOGENOMICS JOURNAL}. LONDON: NATURE PUBLISHING GROUP, 2017, roč.~17, č.~5, s.~452-460. ISSN~1470-269X. Dostupné z: https://dx.doi.org/10.1038/tpj.2016.55.

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