Reduction of paediatric emergence agitation after
adenotonsillectomy with nalbuphine

J 2017

Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine

VAVŘINA, Martin, Jiří ŽUREK, Michal FEDORA, Petr DOMINIK, Marie FORBELSKÁ et. al.

Základní údaje

Originální název

Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine

Autoři

VAVŘINA, Martin (203 Česká republika, garant, domácí), Jiří ŽUREK (203 Česká republika, domácí), Michal FEDORA (203 Česká republika, domácí), Petr DOMINIK (203 Česká republika, domácí), Marie FORBELSKÁ (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí)

Vydání

Current Pediatric Research, Aligarh, Scientific Publishers of India, 2017, 0971-9032

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30209 Paediatrics

Stát vydavatele

Indie

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Kód RIV

RIV/00216224:14110/17:00098198

Organizační jednotka

Lékařská fakulta

Klíčová slova anglicky

Anaesthesia; Opioid analgesics; Volatile anaesthetics; Sevoflurane; Child; Emergence delirium

Štítky

alphentanil, anesthesia, EL OK, nalbuphine, pediatrics, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 22. 3. 2018 15:43, Soňa Böhmová

Anotace

V originále

Abstract Background and aim: The aim of this prospective, observational study was to evaluate the potential benefit of nalbuphine in paediatric adenotonsillectomy in comparison to alfentanil in the terms of the emergence delirium and other procedural adverse events. Methods: Monitored adverse events were tachycardia, dyspnoea, hypotension, hypertension and emergence agitation according to the adapted Watcha scale. All eligible patients were given oral premedication and general anaesthesia was induced using inhalational or intravenous route. Patients were given nalbuphine (0.1-0.2 mg.kg-1) or alfentanil (10-15 ug.kg-1) and had all requested data recorded in the study form (age, study group, metamizole usage, body weight, total dose of nalbuphine or alfentanil, ASA, studied parameters). Results: Total of 122 patients were enrolled for this study, 8 patients were excluded because of incomplete study form. This resulted in study population of 114 patients. All patients were ASA I–II. No differences in age or body weight were observed. Emergence agitation was significantly (p=0.024) more frequent in the Alfentanil group (39.66%) than in Nalbuphine group (19.64%). Tachycardia was significantly more frequent in younger patients. Dyspnoea was significantly dose-dependent and more frequent in lower dosages (p=0.045). Hypertension was more frequent in patients with higher grade of agitation, but statistically significant only in the Alfentanil group (p=0.044). Conclusion: Nalbuphine in the setting of paediatric adenotonsillectomy makes a good alternative to short acting opioid and postoperative analgesia using NSAID or other nonopioid analgesics. Our results show that nalbuphine provides less emergence agitation and therefore provides a patient better early postoperative outcome.

Citovat

VAVŘINA, Martin, Jiří ŽUREK, Michal FEDORA, Petr DOMINIK, Marie FORBELSKÁ a Julie BIENERTOVÁ VAŠKŮ. Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine. Current Pediatric Research. Aligarh: Scientific Publishers of India, 2017, roč. 21, č. 3, s. 490-496. ISSN 0971-9032.

@article{1394976,
   author = {Vavřina, Martin and Žurek, Jiří and Fedora, Michal and Dominik, Petr and Forbelská, Marie and Bienertová Vašků, Julie},
   article_location = {Aligarh},
   article_number = {3},
   keywords = {Anaesthesia; Opioid analgesics; Volatile anaesthetics; Sevoflurane; Child; Emergence delirium},
   language = {eng},
   issn = {0971-9032},
   journal = {Current Pediatric Research},
   title = {Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine},
   url = {http://www.currentpediatrics.com/articles/reduction-of-paediatric-emergence-agitation-after-adenotonsillectomywith-nalbuphine.pdf},
   volume = {21},
   year = {2017}
}

TY  - JOUR
ID  - 1394976
AU  - Vavřina, Martin - Žurek, Jiří - Fedora, Michal - Dominik, Petr - Forbelská, Marie - Bienertová Vašků, Julie
PY  - 2017
TI  - Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine
JF  - Current Pediatric Research
VL  - 21
IS  - 3
SP  - 490-496
EP  - 490-496
PB  - Scientific Publishers of India
SN  - 09719032
KW  - Anaesthesia
KW  - Opioid analgesics
KW  - Volatile anaesthetics
KW  - Sevoflurane
KW  - Child
KW  - Emergence delirium
UR  - http://www.currentpediatrics.com/articles/reduction-of-paediatric-emergence-agitation-after-adenotonsillectomywith-nalbuphine.pdf
L2  - http://www.currentpediatrics.com/articles/reduction-of-paediatric-emergence-agitation-after-adenotonsillectomywith-nalbuphine.pdf
N2  - Abstract Background and aim: The aim of this prospective, observational study was to evaluate the potential benefit of nalbuphine in paediatric adenotonsillectomy in comparison to alfentanil in the terms of the emergence delirium and other procedural adverse events. Methods: Monitored adverse events were tachycardia, dyspnoea, hypotension, hypertension and emergence agitation according to the adapted Watcha scale. All eligible patients were given oral premedication and general anaesthesia was induced using inhalational or intravenous route. Patients were given nalbuphine (0.1-0.2 mg.kg-1) or alfentanil (10-15 ug.kg-1) and had all requested data recorded in the study form (age, study group, metamizole usage, body weight, total dose of nalbuphine or alfentanil, ASA, studied parameters). Results: Total of 122 patients were enrolled for this study, 8 patients were excluded because of incomplete study form. This resulted in study population of 114 patients. All patients were ASA I–II. No differences in age or body weight were observed. Emergence agitation was significantly (p=0.024) more frequent in the Alfentanil group (39.66%) than in Nalbuphine group (19.64%). Tachycardia was significantly more frequent in younger patients. Dyspnoea was significantly dose-dependent and more frequent in lower dosages (p=0.045). Hypertension was more frequent in patients with higher grade of agitation, but statistically significant only in the Alfentanil group (p=0.044). Conclusion: Nalbuphine in the setting of paediatric adenotonsillectomy makes a good alternative to short acting opioid and postoperative analgesia using NSAID or other nonopioid analgesics. Our results show that nalbuphine provides less emergence agitation and therefore provides a patient better early postoperative outcome.
ER  -

VAVŘINA, Martin, Jiří ŽUREK, Michal FEDORA, Petr DOMINIK, Marie FORBELSKÁ a Julie BIENERTOVÁ VAŠKŮ. Reduction of paediatric emergence agitation after adenotonsillectomy with nalbuphine. \textit{Current Pediatric Research}. Aligarh: Scientific Publishers of India, 2017, roč.~21, č.~3, s.~490-496. ISSN~0971-9032.

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