The connections of Wnt pathway components with cell cycle and
centrosome: side effects or a hidden logic?

J 2017

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

BRYJA, Vítězslav, Igor ČERVENKA a Lukáš ČAJÁNEK

Základní údaje

Originální název

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

Autoři

BRYJA, Vítězslav (203 Česká republika, garant, domácí), Igor ČERVENKA (703 Slovensko) a Lukáš ČAJÁNEK (203 Česká republika, domácí)

Vydání

Critical Reviews in Biochemistry and Molecular Biology, Abingdon, TAYLOR & FRANCIS LTD, 2017, 1040-9238

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10608 Biochemistry and molecular biology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 5.279

Kód RIV

RIV/00216224:14310/17:00095167

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1080/10409238.2017.1350135

UT WoS

000416064400003

Klíčová slova anglicky

Wnt; centrosome; cilium; cell cycle; crosstalk; planar cell polarity

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 12. 4. 2018 13:17, Ing. Nicole Zrilić

Anotace

V originále

Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components – such as beta-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms – such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response

Návaznosti

GA15-21789S, projekt VaV

Název: Dishevelled - identifikace základních koordinát

Investor: Grantová agentura ČR, Dishevelled - identifikace základních koordinát

GA17-16680S, projekt VaV

Název: Nové postupy pro určení aktivity dráhy planární buněčné polarity (PCP)

Investor: Grantová agentura ČR, Nové postupy pro určení aktivity dráhy planární buněčné polarity (PCP)

GJ16-03269Y, projekt VaV

Název: Tau tubulin kináza 2 v ciliogenezi: molekulární mechanismy a funkční důsledky

Investor: Grantová agentura ČR, Tau tubulin kináza 2 v ciliogenezi: molekularní mechanismy a funkční důsledky

MUNI/G/1100/2016, interní kód MU

Název: Computational chemistry for Wnt signaling pathway

Investor: Masarykova univerzita, Computational chemistry for Wnt signaling pathway, INTERDISCIPLINARY - Mezioborové výzkumné projekty

ROZV/24/LF/2016, interní kód MU

Název: LF - Příspěvek IP 2016

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek IP 2016

Citovat

BRYJA, Vítězslav, Igor ČERVENKA a Lukáš ČAJÁNEK. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? Critical Reviews in Biochemistry and Molecular Biology. Abingdon: TAYLOR & FRANCIS LTD, 2017, roč. 52, č. 6, s. 614-637. ISSN 1040-9238. Dostupné z: https://dx.doi.org/10.1080/10409238.2017.1350135.

@article{1395481,
   author = {Bryja, Vítězslav and Červenka, Igor and Čajánek, Lukáš},
   article_location = {Abingdon},
   article_number = {6},
   doi = {http://dx.doi.org/10.1080/10409238.2017.1350135},
   keywords = {Wnt; centrosome; cilium; cell cycle; crosstalk; planar cell polarity},
   language = {eng},
   issn = {1040-9238},
   journal = {Critical Reviews in Biochemistry and Molecular Biology},
   title = {The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?},
   url = {http://www.tandfonline.com/doi/abs/10.1080/10409238.2017.1350135?journalCode=ibmg20},
   volume = {52},
   year = {2017}
}

TY  - JOUR
ID  - 1395481
AU  - Bryja, Vítězslav - Červenka, Igor - Čajánek, Lukáš
PY  - 2017
TI  - The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?
JF  - Critical Reviews in Biochemistry and Molecular Biology
VL  - 52
IS  - 6
SP  - 614-637
EP  - 614-637
PB  - TAYLOR & FRANCIS LTD
SN  - 10409238
KW  - Wnt
KW  - centrosome
KW  - cilium
KW  - cell cycle
KW  - crosstalk
KW  - planar cell polarity
UR  - http://www.tandfonline.com/doi/abs/10.1080/10409238.2017.1350135?journalCode=ibmg20
N2  - Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components – such as beta-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms – such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response
ER  -

BRYJA, Vítězslav, Igor ČERVENKA a Lukáš ČAJÁNEK. The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic? \textit{Critical Reviews in Biochemistry and Molecular Biology}. Abingdon: TAYLOR \&{} FRANCIS LTD, 2017, roč.~52, č.~6, s.~614-637. ISSN~1040-9238. Dostupné z: https://dx.doi.org/10.1080/10409238.2017.1350135.

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