J 2017

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

BRYJA, Vítězslav, Igor ČERVENKA and Lukáš ČAJÁNEK

Basic information

Original name

The connections of Wnt pathway components with cell cycle and centrosome: side effects or a hidden logic?

Authors

BRYJA, Vítězslav (203 Czech Republic, guarantor, belonging to the institution), Igor ČERVENKA (703 Slovakia) and Lukáš ČAJÁNEK (203 Czech Republic, belonging to the institution)

Edition

Critical Reviews in Biochemistry and Molecular Biology, Abingdon, TAYLOR & FRANCIS LTD, 2017, 1040-9238

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Impact factor

Impact factor: 5.279

RIV identification code

RIV/00216224:14310/17:00095167

Organization unit

Faculty of Science

DOI

UT WoS

000416064400003

Keywords in English

Wnt; centrosome; cilium; cell cycle; crosstalk; planar cell polarity

Tags

Tags

International impact, Reviewed
Změněno: 12/4/2018 13:17, Ing. Nicole Zrilić

Abstract

V originále

Wnt signaling cascade has developed together with multicellularity to orchestrate the development and homeostasis of complex structures. Wnt pathway components – such as beta-catenin, Dishevelled (DVL), Lrp6, and Axin-- are often dedicated proteins that emerged in evolution together with the Wnt signaling cascade and are believed to function primarily in the Wnt cascade. It is interesting to see that in recent literature many of these proteins are connected with cellular functions that are more ancient and not limited to multicellular organisms – such as cell cycle regulation, centrosome biology, or cell division. In this review, we summarize the recent literature describing this crosstalk. Specifically, we attempt to find the answers to the following questions: Is the response to Wnt ligands regulated by the cell cycle? Is the centrosome and/or cilium required to activate the Wnt pathway? How do Wnt pathway components regulate the centrosomal cycle and cilia formation and function? We critically review the evidence that describes how these connections are regulated and how they help to integrate cell-to-cell communication with the cell and the centrosomal cycle in order to achieve a fine-tuned, physiological response

Links

GA15-21789S, research and development project
Name: Dishevelled - identifikace základních koordinát
Investor: Czech Science Foundation
GA17-16680S, research and development project
Name: Nové postupy pro určení aktivity dráhy planární buněčné polarity (PCP)
Investor: Czech Science Foundation
GJ16-03269Y, research and development project
Name: Tau tubulin kináza 2 v ciliogenezi: molekulární mechanismy a funkční důsledky
Investor: Czech Science Foundation
MUNI/G/1100/2016, interní kód MU
Name: Computational chemistry for Wnt signaling pathway
Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects
ROZV/24/LF/2016, interní kód MU
Name: LF - Příspěvek IP 2016
Investor: Ministry of Education, Youth and Sports of the CR