Další formáty:
BibTeX
LaTeX
RIS
@proceedings{1395681, author = {Deissová, Tereza and Bořilová Linhartová, Petra and Marek, Filip and Dolina, Jiří and Křenek, Adam and Kala, Zdeněk and Izakovičová Hollá, Lydie}, booktitle = {XVIII. Setkání biochemiků a molekulárních biologů, Brno}, keywords = {gastroesophageal reflux disease; forkhead box F1; major histocompatibility complex; gene polymorphism}, language = {eng}, isbn = {978-80-210-8765-1}, title = {Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment}, year = {2017} }
TY - CONF ID - 1395681 AU - Deissová, Tereza - Bořilová Linhartová, Petra - Marek, Filip - Dolina, Jiří - Křenek, Adam - Kala, Zdeněk - Izakovičová Hollá, Lydie PY - 2017 TI - Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment SN - 9788021087651 KW - gastroesophageal reflux disease KW - forkhead box F1 KW - major histocompatibility complex KW - gene polymorphism N2 - Background: Gastroesophageal reflux disease (GERD) is associated with functional and structural abnormalities which lead to recurrent exposure of the esophagus to acidic refluxate of gastric contents. Genetic predispositions play an important role in the etiopathogenesis of this multifactorial disease. The aim of this study was to analyze the relationship between the variants in forkhead box F1 (FOXF1) and major histocompatibility complex (MHC) selected within previous genome-wide and case-control association studies and GERD development in Czech patients. Subjects and Methods: In this case-control study, 302 patients with GERD and 124 healthy controls were genotyped for single nucleotide polymorphisms (SNPs) FOXF1 (rs9936833) and MHC (rs9257809) by TaqMan® PCR method. Diagnosis was determined based on clinical symptoms (heartburn, regurgitation), esophagogastroduodenoscopy, manometry of esophagus, 24h pH-metry and histological examination. Results: Although no association between the two studied SNPs and GERD was found, there was a marginal difference in frequencies of the CC genotype FOXF1 (rs9936833) between patients with GERD and acid reflux and healthy controls (P=0.06, OR=1.82, 95%CI=0.91- 3.66). In addition, 89% of patients with GERD suffered from acid reflux in our studied group and the surgical treatment was successful in 83% of cases. Conclusions: Our results suggest that the CC genotype may be a risk factor for acid reflux in patients with GERD. This finding is consistent with the study by Lam et al. (2016), who associated C allele with 2-fold higher risk of acid reflux. This study also confirmed that antireflux surgery is very efficacious in the treatment of GERD. ER -
DEISSOVÁ, Tereza, Petra BOŘILOVÁ LINHARTOVÁ, Filip MAREK, Jiří DOLINA, Adam KŘENEK, Zdeněk KALA a Lydie IZAKOVIČOVÁ HOLLÁ. Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment. In \textit{XVIII. Setkání biochemiků a molekulárních biologů, Brno}. 2017. ISBN~978-80-210-8765-1.
|