Acid reflux in patients with gastroesophageal reflux disease  –
genetic predispositions and efficiency of surgical treatment

a 2017

Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment

DEISSOVÁ, Tereza, Petra BOŘILOVÁ LINHARTOVÁ, Filip MAREK, Jiří DOLINA, Adam KŘENEK et. al.

Základní údaje

Originální název

Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment

Autoři

DEISSOVÁ, Tereza (203 Česká republika, domácí), Petra BOŘILOVÁ LINHARTOVÁ (203 Česká republika, domácí), Filip MAREK (203 Česká republika, domácí), Jiří DOLINA (203 Česká republika, domácí), Adam KŘENEK (203 Česká republika, domácí), Zdeněk KALA (203 Česká republika, domácí) a Lydie IZAKOVIČOVÁ HOLLÁ (203 Česká republika, domácí)

Vydání

XVIII. Setkání biochemiků a molekulárních biologů, Brno, 2017

Další údaje

Jazyk

angličtina

Typ výsledku

Konferenční abstrakt

Obor

30219 Gastroenterology and hepatology

Utajení

není předmětem státního či obchodního tajemství

Kód RIV

RIV/00216224:14110/17:00100751

Organizační jednotka

Lékařská fakulta

ISBN

978-80-210-8765-1

Klíčová slova anglicky

gastroesophageal reflux disease; forkhead box F1; major histocompatibility complex; gene polymorphism

Změněno: 18. 1. 2019 14:36, Mgr. Tereza Deissová

Anotace

V originále

Background: Gastroesophageal reflux disease (GERD) is associated with functional and structural abnormalities which lead to recurrent exposure of the esophagus to acidic refluxate of gastric contents. Genetic predispositions play an important role in the etiopathogenesis of this multifactorial disease. The aim of this study was to analyze the relationship between the variants in forkhead box F1 (FOXF1) and major histocompatibility complex (MHC) selected within previous genome-wide and case-control association studies and GERD development in Czech patients. Subjects and Methods: In this case-control study, 302 patients with GERD and 124 healthy controls were genotyped for single nucleotide polymorphisms (SNPs) FOXF1 (rs9936833) and MHC (rs9257809) by TaqMan® PCR method. Diagnosis was determined based on clinical symptoms (heartburn, regurgitation), esophagogastroduodenoscopy, manometry of esophagus, 24h pH-metry and histological examination. Results: Although no association between the two studied SNPs and GERD was found, there was a marginal difference in frequencies of the CC genotype FOXF1 (rs9936833) between patients with GERD and acid reflux and healthy controls (P=0.06, OR=1.82, 95%CI=0.91- 3.66). In addition, 89% of patients with GERD suffered from acid reflux in our studied group and the surgical treatment was successful in 83% of cases. Conclusions: Our results suggest that the CC genotype may be a risk factor for acid reflux in patients with GERD. This finding is consistent with the study by Lam et al. (2016), who associated C allele with 2-fold higher risk of acid reflux. This study also confirmed that antireflux surgery is very efficacious in the treatment of GERD.

Návaznosti

GB14-37368G, projekt VaV

Název: Centrum orofaciálního vývoje a regenerace

Investor: Grantová agentura ČR, Centrum orofaciálního vývoje a regenerace

MUNI/A/0948/2016, interní kód MU

Název: Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba

Investor: Masarykova univerzita, Nemoci dutiny ústní – etiopatogeneze, klinické projevy, diagnostika a léčba, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

ROZV/25/LF/2017, interní kód MU

Název: LF - Příspěvek na IP 2017

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, LF - Příspěvek na IP 2017, Interní rozvojové projekty

Citovat

DEISSOVÁ, Tereza, Petra BOŘILOVÁ LINHARTOVÁ, Filip MAREK, Jiří DOLINA, Adam KŘENEK, Zdeněk KALA a Lydie IZAKOVIČOVÁ HOLLÁ. Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment. In XVIII. Setkání biochemiků a molekulárních biologů, Brno. 2017. ISBN 978-80-210-8765-1.

@proceedings{1395681,
   author = {Deissová, Tereza and Bořilová Linhartová, Petra and Marek, Filip and Dolina, Jiří and Křenek, Adam and Kala, Zdeněk and Izakovičová Hollá, Lydie},
   booktitle = {XVIII. Setkání biochemiků a molekulárních biologů, Brno},
   keywords = {gastroesophageal reflux disease; forkhead box F1; major histocompatibility complex; gene polymorphism},
   language = {eng},
   isbn = {978-80-210-8765-1},
   title = {Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment},
   year = {2017}
}

TY  - CONF
ID  - 1395681
AU  - Deissová, Tereza - Bořilová Linhartová, Petra - Marek, Filip - Dolina, Jiří - Křenek, Adam - Kala, Zdeněk - Izakovičová Hollá, Lydie
PY  - 2017
TI  - Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment
SN  - 9788021087651
KW  - gastroesophageal reflux disease
KW  - forkhead box F1
KW  - major histocompatibility complex
KW  - gene polymorphism
N2  - Background: Gastroesophageal reflux disease (GERD) is associated with functional and structural abnormalities which lead to recurrent exposure of the esophagus to acidic refluxate of gastric contents. Genetic predispositions play an important role in the etiopathogenesis of this multifactorial disease. The aim of this study was to analyze the relationship between the variants in forkhead box F1 (FOXF1) and major histocompatibility complex (MHC) selected within previous genome-wide and case-control association studies and GERD development in Czech patients. Subjects and Methods: In this case-control study, 302 patients with GERD and 124 healthy controls were genotyped for single nucleotide polymorphisms (SNPs) FOXF1 (rs9936833) and MHC (rs9257809) by TaqMan® PCR method. Diagnosis was determined based on clinical symptoms (heartburn, regurgitation), esophagogastroduodenoscopy, manometry of esophagus, 24h pH-metry and histological examination. Results: Although no association between the two studied SNPs and GERD was found, there was a marginal difference in frequencies of the CC genotype FOXF1 (rs9936833) between patients with GERD and acid reflux and healthy controls (P=0.06, OR=1.82, 95%CI=0.91- 3.66). In addition, 89% of patients with GERD suffered from acid reflux in our studied group and the surgical treatment was successful in 83% of cases. Conclusions: Our results suggest that the CC genotype may be a risk factor for acid reflux in patients with GERD. This finding is consistent with the study by Lam et al. (2016), who associated C allele with 2-fold higher risk of acid reflux. This study also confirmed that antireflux surgery is very efficacious in the treatment of GERD.
ER  -

DEISSOVÁ, Tereza, Petra BOŘILOVÁ LINHARTOVÁ, Filip MAREK, Jiří DOLINA, Adam KŘENEK, Zdeněk KALA a Lydie IZAKOVIČOVÁ HOLLÁ. Acid reflux in patients with gastroesophageal reflux disease – genetic predispositions and efficiency of surgical treatment. In \textit{XVIII. Setkání biochemiků a molekulárních biologů, Brno}. 2017. ISBN~978-80-210-8765-1.

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