A head-to-head comparison of 4-L polyethylene glycol and
low-volume solutions before colonoscopy: which is the best? A
multicentre, randomized trial

J 2017

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

KOJECKÝ, Vladimír; J. MATOUS; R. KEIL; Milan DASTYCH; Radek KROUPA et. al.

Basic information

Original name

A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial

Authors

KOJECKÝ, Vladimír (203 Czech Republic); J. MATOUS (203 Czech Republic); R. KEIL (203 Czech Republic); Milan DASTYCH (203 Czech Republic, guarantor, belonging to the institution); Radek KROUPA (203 Czech Republic, belonging to the institution); Z. ZADOROVA (203 Czech Republic); M. VARGA (203 Czech Republic); Jiří DOLINA (203 Czech Republic, belonging to the institution); M. KMENT (203 Czech Republic) and Aleš HEP (203 Czech Republic, belonging to the institution)

Edition

International Journal of Colorectal Disease, New York, Springer, 2017, 0179-1958

Other information

Language

English

Type of outcome

Article in a journal

Field of Study

30219 Gastroenterology and hepatology

Country of publisher

United States of America

Confidentiality degree

is not subject to a state or trade secret

Impact factor

Impact factor: 2.533

RIV identification code

RIV/00216224:14110/17:00098392

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1007/s00384-017-2901-x

UT WoS

000415692100014

EID Scopus

2-s2.0-85029905735

Keywords in English

Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol

Abstract

In the original language

Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.

Cite

KOJECKÝ, Vladimír; J. MATOUS; R. KEIL; Milan DASTYCH; Radek KROUPA; Z. ZADOROVA; M. VARGA; Jiří DOLINA; M. KMENT and Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. International Journal of Colorectal Disease. New York: Springer, 2017, vol. 32, No 12, p. 1763-1766. ISSN 0179-1958. Available from: https://dx.doi.org/10.1007/s00384-017-2901-x.

@article{1396180,
   author = {Kojecký, Vladimír and Matous, J. and Keil, R. and Dastych, Milan and Kroupa, Radek and Zadorova, Z. and Varga, M. and Dolina, Jiří and Kment, M. and Hep, Aleš},
   article_location = {New York},
   article_number = {12},
   doi = {http://dx.doi.org/10.1007/s00384-017-2901-x},
   keywords = {Ascorbic acid; Colonoscopy; Magnesium citrate; Picosulfate sodium; Polyethylene glycol},
   language = {eng},
   issn = {0179-1958},
   journal = {International Journal of Colorectal Disease},
   title = {A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1396180
AU  - Kojecký, Vladimír - Matous, J. - Keil, R. - Dastych, Milan - Kroupa, Radek - Zadorova, Z. - Varga, M. - Dolina, Jiří - Kment, M. - Hep, Aleš
PY  - 2017
TI  - A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial
JF  - International Journal of Colorectal Disease
VL  - 32
IS  - 12
SP  - 1763-1766
EP  - 1763-1766
PB  - Springer
SN  - 01791958
KW  - Ascorbic acid
KW  - Colonoscopy
KW  - Magnesium citrate
KW  - Picosulfate sodium
KW  - Polyethylene glycol
N2  - Purpose: The purpose of this study is to compare the efficacy and tolerability of polyethylene glycol (PEG) to sodium picosulfate/magnesium citrate (SPMC) and low-volume polyethylene glycol/ascorbic acid (PEGA) in a single- or split-dose regimen for colonoscopy bowel preparation. Methods: This was a prospective, randomized, endoscopist-blinded, multicentre study. Outpatients received either PEG or SPMC or PEGA in a single or a split dose before the colonoscopy. Quality and tolerability of the preparation and complaints during preparation were recorded. Results: Nine hundred seventy-three patients were analysed. Satisfactory bowel cleansing (Aronchick score 1 + 2) was more frequent when a split dose was used irrespective of the solution type (PEG 90.1 vs 68.8%, PEGA 86.0 vs 71.6%, SPMC 84.3 vs 60.2%, p < 0.001). SPMC was the best tolerated followed by PEGA (p < 0.006) and PEG as the worst (p < 0.001). Tolerability did not correlate with the regimen and amount of the solution used. Female gender is associated with a higher incidence of nausea, vomiting and pain (p < 0.029). Conclusions: Both PEG, PEGA and SPMC are fully comparable in terms of colonic cleansing when used in similar regimens. The split-dose preparation is more effective in all agents. SPMC and PEGA are better tolerated than PEG. The preparation regimen and/or the volume do not affect tolerability.
ER  -

KOJECKÝ, Vladimír; J. MATOUS; R. KEIL; Milan DASTYCH; Radek KROUPA; Z. ZADOROVA; M. VARGA; Jiří DOLINA; M. KMENT and Aleš HEP. A head-to-head comparison of 4-L polyethylene glycol and low-volume solutions before colonoscopy: which is the best? A multicentre, randomized trial. \textit{International Journal of Colorectal Disease}. New York: Springer, 2017, vol.~32, No~12, p.~1763-1766. ISSN~0179-1958. Available from: https://dx.doi.org/10.1007/s00384-017-2901-x.

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