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@article{1396221,
author = {Krutova, M. and Matejkova, J. and Drevinek, P. and Kuijper, E.J. and Nyc, O. and Tejkalová, Renata},
article_location = {NEW YORK},
article_number = {11},
doi = {http://dx.doi.org/10.1007/s10096-017-3055-z},
keywords = {Clostridium difficile; Clostridium difficile infection; Capillary electrophoresis ribotyping; Toxin genes; CDI surveillance; Fluoroquinolones},
language = {eng},
issn = {0934-9723},
journal = {EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES},
title = {Increasing incidence of Clostridium difficile ribotype 001 associated with severe course of the infection and previous fluoroquinolone use in the Czech Republic, 2015},
url = {http://dx.doi.org/10.1007/s10096-017-3055-z},
volume = {36},
year = {2017}
}
TY - JOUR
ID - 1396221
AU - Krutova, M. - Matejkova, J. - Drevinek, P. - Kuijper, E.J. - Nyc, O. - Tejkalová, Renata
PY - 2017
TI - Increasing incidence of Clostridium difficile ribotype 001 associated with severe course of the infection and previous fluoroquinolone use in the Czech Republic, 2015
JF - EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
VL - 36
IS - 11
SP - 2251-2258
EP - 2251-2258
PB - SPRINGER
SN - 09349723
KW - Clostridium difficile
KW - Clostridium difficile infection
KW - Capillary electrophoresis ribotyping
KW - Toxin genes
KW - CDI surveillance
KW - Fluoroquinolones
UR - http://dx.doi.org/10.1007/s10096-017-3055-z
L2 - http://dx.doi.org/10.1007/s10096-017-3055-z
N2 - The aim of the study was to provide an update on the epidemiology of C. difficile infection (CDI) in a representative number of hospitals within the Czech Republic in 2015. In 2015, twenty-eight Czech hospitals were invited to participate in a CDI study. Laboratories sent the first 20 consecutive C. difficile isolates for characterization by capillary-electrophoresis (CE) ribotyping and the presence of toxin genes and collected patient data on previous hospitalization, antibiotic treatment, the number of CDI episodes and the course of CDI. The mean incidence of CDI was 5.2 [95% CI 4.2-6.2] cases per 10,000 patient-bed days in 27 hospitals in 2015. Of 490 C. difficile isolates, the prevalent PCR ribotypes (RTs) were 001 (n = 164, 33.5%) and 176 (n = 125, 25.5%) followed by 014 (n = 37, 7.6%), 012 (n = 17, 3.5%), 020 (n = 16, 3.3%), 017 (n = 14, 2.9%) and 002 (n = 11, 2.2%). A severe course of CDI was reported in 104 cases (21.2%) with significant association with RT001 infection (p = 0.03). CDI recurrence was 10.8% (n = 53). The previous use of fluoroquinolones was associated with RTs 001 and 176 CDIs (p = 0.046 and p = 0.041). We observed a persistence of RTs 001 and 176 CDIs in the Czech Republic that was associated with the previous use of fluoroquinolones. This highlights the need for a reduction in fluoroquinolone use in Czech hospital settings.
ER -
KRUTOVA, M., J. MATEJKOVA, P. DREVINEK, E.J. KUIJPER a O. NYC. Increasing incidence of Clostridium difficile ribotype 001 associated with severe course of the infection and previous fluoroquinolone use in the Czech Republic, 2015. \textit{EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY \&{}amp; INFECTIOUS DISEASES}. NEW YORK: SPRINGER, 2017, roč.~36, č.~11, s.~2251-2258. ISSN~0934-9723. Dostupné z: https://dx.doi.org/10.1007/s10096-017-3055-z.
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