Chromatic pupillography in hemianopia patients with homonymous
visual field defects

J 2017

Chromatic pupillography in hemianopia patients with homonymous visual field defects

MAEDA, F., C. KELBSCH, T. STRASSER, Karolína SKORKOVSKÁ, T. PETERS et. al.

Základní údaje

Originální název

Chromatic pupillography in hemianopia patients with homonymous visual field defects

Autoři

MAEDA, F. (276 Německo), C. KELBSCH (276 Německo), T. STRASSER (276 Německo), Karolína SKORKOVSKÁ (203 Česká republika, garant, domácí), T. PETERS (276 Německo), B. WILHELM (276 Německo) a H. WILHELM (276 Německo)

Vydání

Graefes Archive for Clinical and Experimental Ophthalmology, New York, Springer, 2017, 0721-832X

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30207 Ophthalmology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.249

Kód RIV

RIV/00216224:14110/17:00098414

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s00417-017-3721-y

UT WoS

000407587600020

Klíčová slova anglicky

Pupil light reflex; Intrinsically photosensitive retinal ganglion cells; Homonymous hemianopia; Pupillary hemihypokinesia; Dorsal midbrain; Visual cortex

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 17:50, Soňa Böhmová

Anotace

V originále

The pupil light reflex is considered to be a simple subcortical reflex. However, many studies have proven that patients with isolated occipital lesions with homonymous hemianopia show pupillary hemihypokinesia. Our hypothesis is that the afferent pupillary system consists of two pathways: one via intrinsically photosensitive retinal ganglion cells (ipRGCs), the other running through the normal RGCs via the visual cortex. The purpose of this study was to test the hypothesis of these two separate pupillomotor pathways. 12 patients (59.1 +/- 18.8 years) with homonymous hemianopia due to post-geniculate lesions of the visual pathway and 20 normal controls (58.6 +/- 12.9 years) were examined using chromatic pupillography: stimulus intensity was 28 lx corneal illumination, stimulus duration was 4.0 s, and the stimulus wavelengths were 420 +/- 20 nm (blue) and 605 +/- 20 nm (red), respectively. The examined parameters were baseline pupil diameter, latency, and relative amplitudes (absolute amplitudes compared to baseline), measured at maximal constriction, at 3 s after stimulus onset, at stimulus offset, and at 3 s and 7 s after stimulus offset. The relative amplitudes for the red stimulus were significantly smaller for hemianopia patients compared to the normal controls [maximal constriction: 35.6 +/- 5.9% (hemianopia) to 42.3 +/- 5.7% (normal); p = 0.004; 3 s after stimulus onset: p = 0.004; stimulus offset: p = 0.001]. No significant differences in any parameter were found between the two groups using the blue stimulus. The results support the hypothesis that the ipRGC pathway is mainly subcortical, whereas a second, non-ipRGC pathway via the occipital cortex exists.

Citovat

MAEDA, F., C. KELBSCH, T. STRASSER, Karolína SKORKOVSKÁ, T. PETERS, B. WILHELM a H. WILHELM. Chromatic pupillography in hemianopia patients with homonymous visual field defects. Graefes Archive for Clinical and Experimental Ophthalmology. New York: Springer, 2017, roč. 255, č. 9, s. 1837-1842. ISSN 0721-832X. Dostupné z: https://dx.doi.org/10.1007/s00417-017-3721-y.

@article{1396239,
   author = {Maeda, F. and Kelbsch, C. and Strasser, T. and Skorkovská, Karolína and Peters, T. and Wilhelm, B. and Wilhelm, H.},
   article_location = {New York},
   article_number = {9},
   doi = {http://dx.doi.org/10.1007/s00417-017-3721-y},
   keywords = {Pupil light reflex; Intrinsically photosensitive retinal ganglion cells; Homonymous hemianopia; Pupillary hemihypokinesia; Dorsal midbrain; Visual cortex},
   language = {eng},
   issn = {0721-832X},
   journal = {Graefes Archive for Clinical and Experimental Ophthalmology},
   title = {Chromatic pupillography in hemianopia patients with homonymous visual field defects},
   volume = {255},
   year = {2017}
}

TY  - JOUR
ID  - 1396239
AU  - Maeda, F. - Kelbsch, C. - Strasser, T. - Skorkovská, Karolína - Peters, T. - Wilhelm, B. - Wilhelm, H.
PY  - 2017
TI  - Chromatic pupillography in hemianopia patients with homonymous visual field defects
JF  - Graefes Archive for Clinical and Experimental Ophthalmology
VL  - 255
IS  - 9
SP  - 1837-1842
EP  - 1837-1842
PB  - Springer
SN  - 0721832X
KW  - Pupil light reflex
KW  - Intrinsically photosensitive retinal ganglion cells
KW  - Homonymous hemianopia
KW  - Pupillary hemihypokinesia
KW  - Dorsal midbrain
KW  - Visual cortex
N2  - The pupil light reflex is considered to be a simple subcortical reflex. However, many studies have proven that patients with isolated occipital lesions with homonymous hemianopia show pupillary hemihypokinesia. Our hypothesis is that the afferent pupillary system consists of two pathways: one via intrinsically photosensitive retinal ganglion cells (ipRGCs), the other running through the normal RGCs via the visual cortex. The purpose of this study was to test the hypothesis of these two separate pupillomotor pathways. 12 patients (59.1 +/- 18.8 years) with homonymous hemianopia due to post-geniculate lesions of the visual pathway and 20 normal controls (58.6 +/- 12.9 years) were examined using chromatic pupillography: stimulus intensity was 28 lx corneal illumination, stimulus duration was 4.0 s, and the stimulus wavelengths were 420 +/- 20 nm (blue) and 605 +/- 20 nm (red), respectively. The examined parameters were baseline pupil diameter, latency, and relative amplitudes (absolute amplitudes compared to baseline), measured at maximal constriction, at 3 s after stimulus onset, at stimulus offset, and at 3 s and 7 s after stimulus offset. The relative amplitudes for the red stimulus were significantly smaller for hemianopia patients compared to the normal controls [maximal constriction: 35.6 +/- 5.9% (hemianopia) to 42.3 +/- 5.7% (normal); p = 0.004; 3 s after stimulus onset: p = 0.004; stimulus offset: p = 0.001]. No significant differences in any parameter were found between the two groups using the blue stimulus. The results support the hypothesis that the ipRGC pathway is mainly subcortical, whereas a second, non-ipRGC pathway via the occipital cortex exists.
ER  -

MAEDA, F., C. KELBSCH, T. STRASSER, Karolína SKORKOVSKÁ, T. PETERS, B. WILHELM a H. WILHELM. Chromatic pupillography in hemianopia patients with homonymous visual field defects. \textit{Graefes Archive for Clinical and Experimental Ophthalmology}. New York: Springer, 2017, roč.~255, č.~9, s.~1837-1842. ISSN~0721-832X. Dostupné z: https://dx.doi.org/10.1007/s00417-017-3721-y.

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