The burden and epidemiology of community-acquired central
nervous system infections: a multinational study

J 2017

The burden and epidemiology of community-acquired central nervous system infections: a multinational study

ERDEM, Hakan, A. INAN, E. GUVEN, S. HARGREAVES, L. LARSEN et. al.

Základní údaje

Originální název

The burden and epidemiology of community-acquired central nervous system infections: a multinational study

Autoři

ERDEM, Hakan (792 Turecko), A. INAN (792 Turecko), E. GUVEN (792 Turecko), S. HARGREAVES (826 Velká Británie a Severní Irsko), L. LARSEN (208 Dánsko), G. SHEHATA (818 Egypt), Eva PERNICOVÁ (203 Česká republika), E. KHAN (586 Pákistán), Lenka BAŠTÁKOVÁ (703 Slovensko, garant, domácí), S. NAMANI (95 Kosovo), A. HARXHI (8 Albánie), T. ROGANOVIC (70 Bosna a Hercegovina), B. LAKATOS (348 Maďarsko), S. UYSAL (792 Turecko), O. R. SIPAHI (792 Turecko), A. CRISAN (642 Rumunsko), E. MIFTODE (642 Rumunsko), Roman STEBEL (203 Česká republika, domácí), B. JEGOROVIC (688 Srbsko), Z. FEHER (348 Maďarsko), C. JEKKEL (348 Maďarsko), N. PANDAK (191 Chorvatsko), A. MORAVVEJI (364 Írán), H. YILMAZ (792 Turecko), A. KHALIFA (760 Sýrie), U. MUSABAK (792 Turecko), S. YILMAZ (792 Turecko), A. JOUHAR (760 Sýrie), N. OZTOPRAK (792 Turecko), X. ARGEMI (250 Francie), M. BALDEYROU (250 Francie), G. BELLAUD (250 Francie), R. V. MOROTI (642 Rumunsko), R. HASBUN (840 Spojené státy), L. SALAZAR (840 Spojené státy), R. TEKIN (792 Turecko), A. CANESTRI (250 Francie), L. CALKIC (70 Bosna a Hercegovina), L. PRATICO (380 Itálie), F. YILMAZ-KARADAG (792 Turecko), L. SANTOS (620 Portugalsko), A. PINTO (620 Portugalsko), F. KAPTAN (792 Turecko), P. BOSSI (250 Francie), J. ARON (250 Francie), A. DUISSENOVA (398 Kazachstán), G. SHOPAYEVA (398 Kazachstán), B. UTAGANOV (398 Kazachstán), S. GRGIC (70 Bosna a Hercegovina), G. ERSOZ (792 Turecko), A. K. L. WU (156 Čína), K. C. LUNG (156 Čína), A. BRUZSA (348 Maďarsko), L. B. RADIC (191 Chorvatsko), H. KAHRAMAN (792 Turecko), M. MOMEN-HERAVI (364 Írán), S. KULZHANOVA (398 Kazachstán), F. RIGO (380 Itálie), M. KONKAYEVA (398 Kazachstán), Z. SMAGULOVA (398 Kazachstán), T. TANG (156 Čína), P. CHAN (156 Čína), S. AHMETAGIC (70 Bosna a Hercegovina), H. POROBIC-JAHIC (70 Bosna a Hercegovina), F. MORADI (364 Írán), S. KAYA (792 Turecko), Y. CAG (792 Turecko), A. BOHR (208 Dánsko), C. ARTUK (792 Turecko), I. CELIK (792 Turecko), M. AMSILLI (250 Francie), H. C. GUL (792 Turecko), A. CASCIO (380 Itálie), M. LANZAFAME (380 Itálie) a M. NASSAR (682 Saúdská Arábie)

Vydání

European Journal of Clinical Microbiology & Infectious Diseases, New York, Springer, 2017, 0934-9723

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30303 Infectious Diseases

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.537

Kód RIV

RIV/00216224:14110/17:00098556

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1007/s10096-017-2973-0

UT WoS

000407582200010

Klíčová slova anglicky

Central nervous system infections; Epidemiology; Streptococcus pneumoniae; Neurosyphilis; Neuroborreliosis; CNS tuberculosis

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2018 18:00, Soňa Böhmová

Anotace

V originále

Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.

Citovat

ERDEM, Hakan, A. INAN, E. GUVEN, S. HARGREAVES, L. LARSEN, G. SHEHATA, Eva PERNICOVÁ, E. KHAN, Lenka BAŠTÁKOVÁ, S. NAMANI, A. HARXHI, T. ROGANOVIC, B. LAKATOS, S. UYSAL, O. R. SIPAHI, A. CRISAN, E. MIFTODE, Roman STEBEL, B. JEGOROVIC, Z. FEHER, C. JEKKEL, N. PANDAK, A. MORAVVEJI, H. YILMAZ, A. KHALIFA, U. MUSABAK, S. YILMAZ, A. JOUHAR, N. OZTOPRAK, X. ARGEMI, M. BALDEYROU, G. BELLAUD, R. V. MOROTI, R. HASBUN, L. SALAZAR, R. TEKIN, A. CANESTRI, L. CALKIC, L. PRATICO, F. YILMAZ-KARADAG, L. SANTOS, A. PINTO, F. KAPTAN, P. BOSSI, J. ARON, A. DUISSENOVA, G. SHOPAYEVA, B. UTAGANOV, S. GRGIC, G. ERSOZ, A. K. L. WU, K. C. LUNG, A. BRUZSA, L. B. RADIC, H. KAHRAMAN, M. MOMEN-HERAVI, S. KULZHANOVA, F. RIGO, M. KONKAYEVA, Z. SMAGULOVA, T. TANG, P. CHAN, S. AHMETAGIC, H. POROBIC-JAHIC, F. MORADI, S. KAYA, Y. CAG, A. BOHR, C. ARTUK, I. CELIK, M. AMSILLI, H. C. GUL, A. CASCIO, M. LANZAFAME a M. NASSAR. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. European Journal of Clinical Microbiology & Infectious Diseases. New York: Springer, 2017, roč. 36, č. 9, s. 1595-1611. ISSN 0934-9723. Dostupné z: https://dx.doi.org/10.1007/s10096-017-2973-0.

@article{1397293,
   author = {Erdem, Hakan and Inan, A. and Guven, E. and Hargreaves, S. and Larsen, L. and Shehata, G. and Pernicová, Eva and Khan, E. and Baštáková, Lenka and Namani, S. and Harxhi, A. and Roganovic, T. and Lakatos, B. and Uysal, S. and Sipahi, O. R. and Crisan, A. and Miftode, E. and Stebel, Roman and Jegorovic, B. and Feher, Z. and Jekkel, C. and Pandak, N. and Moravveji, A. and Yilmaz, H. and Khalifa, A. and Musabak, U. and Yilmaz, S. and Jouhar, A. and Oztoprak, N. and Argemi, X. and Baldeyrou, M. and Bellaud, G. and Moroti, R. V. and Hasbun, R. and Salazar, L. and Tekin, R. and Canestri, A. and Calkic, L. and Pratico, L. and YilmazandKaradag, F. and Santos, L. and Pinto, A. and Kaptan, F. and Bossi, P. and Aron, J. and Duissenova, A. and Shopayeva, G. and Utaganov, B. and Grgic, S. and Ersoz, G. and Wu, A. K. L. and Lung, K. C. and Bruzsa, A. and Radic, L. B. and Kahraman, H. and MomenandHeravi, M. and Kulzhanova, S. and Rigo, F. and Konkayeva, M. and Smagulova, Z. and Tang, T. and Chan, P. and Ahmetagic, S. and PorobicandJahic, H. and Moradi, F. and Kaya, S. and Cag, Y. and Bohr, A. and Artuk, C. and Celik, I. and Amsilli, M. and Gul, H. C. and Cascio, A. and Lanzafame, M. and Nassar, M.},
   article_location = {New York},
   article_number = {9},
   doi = {http://dx.doi.org/10.1007/s10096-017-2973-0},
   keywords = {Central nervous system infections; Epidemiology; Streptococcus pneumoniae; Neurosyphilis; Neuroborreliosis; CNS tuberculosis},
   language = {eng},
   issn = {0934-9723},
   journal = {European Journal of Clinical Microbiology & Infectious Diseases},
   title = {The burden and epidemiology of community-acquired central nervous system infections: a multinational study},
   url = {https://link.springer.com/article/10.1007%2Fs10096-017-2973-0},
   volume = {36},
   year = {2017}
}

TY  - JOUR
ID  - 1397293
AU  - Erdem, Hakan - Inan, A. - Guven, E. - Hargreaves, S. - Larsen, L. - Shehata, G. - Pernicová, Eva - Khan, E. - Baštáková, Lenka - Namani, S. - Harxhi, A. - Roganovic, T. - Lakatos, B. - Uysal, S. - Sipahi, O. R. - Crisan, A. - Miftode, E. - Stebel, Roman - Jegorovic, B. - Feher, Z. - Jekkel, C. - Pandak, N. - Moravveji, A. - Yilmaz, H. - Khalifa, A. - Musabak, U. - Yilmaz, S. - Jouhar, A. - Oztoprak, N. - Argemi, X. - Baldeyrou, M. - Bellaud, G. - Moroti, R. V. - Hasbun, R. - Salazar, L. - Tekin, R. - Canestri, A. - Calkic, L. - Pratico, L. - Yilmaz-Karadag, F. - Santos, L. - Pinto, A. - Kaptan, F. - Bossi, P. - Aron, J. - Duissenova, A. - Shopayeva, G. - Utaganov, B. - Grgic, S. - Ersoz, G. - Wu, A. K. L. - Lung, K. C. - Bruzsa, A. - Radic, L. B. - Kahraman, H. - Momen-Heravi, M. - Kulzhanova, S. - Rigo, F. - Konkayeva, M. - Smagulova, Z. - Tang, T. - Chan, P. - Ahmetagic, S. - Porobic-Jahic, H. - Moradi, F. - Kaya, S. - Cag, Y. - Bohr, A. - Artuk, C. - Celik, I. - Amsilli, M. - Gul, H. C. - Cascio, A. - Lanzafame, M. - Nassar, M.
PY  - 2017
TI  - The burden and epidemiology of community-acquired central nervous system infections: a multinational study
JF  - European Journal of Clinical Microbiology & Infectious Diseases
VL  - 36
IS  - 9
SP  - 1595-1611
EP  - 1595-1611
PB  - Springer
SN  - 09349723
KW  - Central nervous system infections
KW  - Epidemiology
KW  - Streptococcus pneumoniae
KW  - Neurosyphilis
KW  - Neuroborreliosis
KW  - CNS tuberculosis
UR  - https://link.springer.com/article/10.1007%2Fs10096-017-2973-0
L2  - https://link.springer.com/article/10.1007%2Fs10096-017-2973-0
N2  - Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. A total of 2583 patients with CA-CNS infections were included from 37 referral centers in 20 countries. Of these, 477 (18.5%) patients survived with sequelae and 227 (8.8%) died, and 1879 (72.7%) patients were discharged with complete cure. The most frequent infecting pathogens in this study were Streptococcus pneumoniae (n = 206, 8%) and Mycobacterium tuberculosis (n = 152, 5.9%). Varicella zoster virus and Listeria were other common pathogens in the elderly. Although staphylococci and Listeria resulted in frequent infections in immunocompromised patients, cryptococci were leading pathogens in human immunodeficiency virus (HIV)-positive individuals. Among the patients with any proven etiology, 96 (8.9%) patients presented with clinical features of a chronic CNS disease. Neurosyphilis, neurobrucellosis, neuroborreliosis, and CNS tuberculosis had a predilection to present chronic courses. Listeria monocytogenes, Staphylococcus aureus, M. tuberculosis, and S. pneumoniae were the most fatal forms, while sequelae were significantly higher for herpes simplex virus type 1 (p < 0.05 for all). Tackling the high burden of CNS infections globally can only be achieved with effective pneumococcal immunization and strategies to eliminate tuberculosis, and more must be done to improve diagnostic capacity.
ER  -

ERDEM, Hakan, A. INAN, E. GUVEN, S. HARGREAVES, L. LARSEN, G. SHEHATA, Eva PERNICOVÁ, E. KHAN, Lenka BAŠTÁKOVÁ, S. NAMANI, A. HARXHI, T. ROGANOVIC, B. LAKATOS, S. UYSAL, O. R. SIPAHI, A. CRISAN, E. MIFTODE, Roman STEBEL, B. JEGOROVIC, Z. FEHER, C. JEKKEL, N. PANDAK, A. MORAVVEJI, H. YILMAZ, A. KHALIFA, U. MUSABAK, S. YILMAZ, A. JOUHAR, N. OZTOPRAK, X. ARGEMI, M. BALDEYROU, G. BELLAUD, R. V. MOROTI, R. HASBUN, L. SALAZAR, R. TEKIN, A. CANESTRI, L. CALKIC, L. PRATICO, F. YILMAZ-KARADAG, L. SANTOS, A. PINTO, F. KAPTAN, P. BOSSI, J. ARON, A. DUISSENOVA, G. SHOPAYEVA, B. UTAGANOV, S. GRGIC, G. ERSOZ, A. K. L. WU, K. C. LUNG, A. BRUZSA, L. B. RADIC, H. KAHRAMAN, M. MOMEN-HERAVI, S. KULZHANOVA, F. RIGO, M. KONKAYEVA, Z. SMAGULOVA, T. TANG, P. CHAN, S. AHMETAGIC, H. POROBIC-JAHIC, F. MORADI, S. KAYA, Y. CAG, A. BOHR, C. ARTUK, I. CELIK, M. AMSILLI, H. C. GUL, A. CASCIO, M. LANZAFAME a M. NASSAR. The burden and epidemiology of community-acquired central nervous system infections: a multinational study. \textit{European Journal of Clinical Microbiology \&{} Infectious Diseases}. New York: Springer, 2017, roč.~36, č.~9, s.~1595-1611. ISSN~0934-9723. Dostupné z: https://dx.doi.org/10.1007/s10096-017-2973-0.

Podrobný výpis o publikaci