| KNOPFOVÁ, Lucia, Elisabetta BIGLIERI, Natalya VOLODKO, Michal MASAŘÍK, Markéta HERMANOVÁ, Jesus Francisco GLAUS GARZÓN, Monika DÚCKA, Tereza KUČÍRKOVÁ, Karel SOUČEK, Jan ŠMARDA, Petr BENEŠ a Lubor BORSIG. Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. Oncogene. London: Nature Publishing Group, 2018, roč. 37, č. 8, s. 1020-1030. ISSN 0950-9232. Dostupné z: https://dx.doi.org/10.1038/onc.2017.392. |
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@article{1398032,
author = {Knopfová, Lucia and Biglieri, Elisabetta and Volodko, Natalya and Masařík, Michal and Hermanová, Markéta and Glaus Garzón, Jesus Francisco and Dúcka, Monika and Kučírková, Tereza and Souček, Karel and Šmarda, Jan and Beneš, Petr and Borsig, Lubor},
article_location = {London},
article_number = {8},
doi = {http://dx.doi.org/10.1038/onc.2017.392},
keywords = {Myb; endothelium; inflammation; Ccl2; metastasis; breast cancer},
language = {eng},
issn = {0950-9232},
journal = {Oncogene},
note = {Rok uplatnění 2018, přenášet do RIV až v roce 2019!},
title = {Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding},
url = {http://dx.doi.org/10.1038/onc.2017.392},
volume = {37},
year = {2018}
}
TY - JOUR
ID - 1398032
AU - Knopfová, Lucia - Biglieri, Elisabetta - Volodko, Natalya - Masařík, Michal - Hermanová, Markéta - Glaus Garzón, Jesus Francisco - Dúcka, Monika - Kučírková, Tereza - Souček, Karel - Šmarda, Jan - Beneš, Petr - Borsig, Lubor
PY - 2018
TI - Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding
JF - Oncogene
VL - 37
IS - 8
SP - 1020-1030
EP - 1020-1030
PB - Nature Publishing Group
SN - 09509232
N1 - Rok uplatnění 2018, přenášet do RIV až v roce 2019!
KW - Myb
KW - endothelium
KW - inflammation
KW - Ccl2
KW - metastasis
KW - breast cancer
UR - http://dx.doi.org/10.1038/onc.2017.392
N2 - Metastasis accounts for most of cancer-related deaths. Paracrine signaling between tumor cells and the stroma induces changes in the tumor microenvironment required for metastasis. Transcription factor c-Myb was associated with breast cancer (BC) progression but its role in metastasis remains unclear. Here we show that increased c-Myb expression in BC cells inhibits spontaneous lung metastasis through impaired tumor cell extravasation. On contrary, BC cells with increased lung metastatic capacity exhibited low c-Myb levels. We identified a specific inflammatory signature, including Ccl2 chemokine; that was expressed in lung metastatic cells but was suppressed in tumor cells with higher c-Myb levels. Tumor cell-derived Ccl2 expression facilitated lung metastasis and rescued trans-endothelial migration of c-Myb overexpressing cells. Clinical data show that the identified inflammatory signature, together with a MYB expression, predicts lung metastasis relapse in BC patients. These results demonstrate that the c-Myb-regulated transcriptional program in BCs results in a blunted inflammatory response and consequently suppresses lung metastasis.
ER -
KNOPFOVÁ, Lucia, Elisabetta BIGLIERI, Natalya VOLODKO, Michal MASAŘÍK, Markéta HERMANOVÁ, Jesus Francisco GLAUS GARZÓN, Monika DÚCKA, Tereza KUČÍRKOVÁ, Karel SOUČEK, Jan ŠMARDA, Petr BENEŠ a Lubor BORSIG. Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding. \textit{Oncogene}. London: Nature Publishing Group, 2018, roč.~37, č.~8, s.~1020-1030. ISSN~0950-9232. Dostupné z: https://dx.doi.org/10.1038/onc.2017.392.
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