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@article{1398261,
author = {Gasparova, I. and Kubatka, P. and Opatrilova, R. and Caprnda, M. and Filipova, S. and Rodrigo, L. and Malan, L. and Mozos, I. and Rabajdova, M. and Nosal, V. and Kobyliak, N. and Valentova, V. and Petrovic, D. and Adamek, M. and Kružliak, Peter},
article_location = {New York},
article_number = {1},
doi = {http://dx.doi.org/10.1007/s00210-016-1320-9},
keywords = {Atrial fibrillation; Atrial remodeling; Oxidative stress; Antioxidants; Prevention; Gene therapy},
language = {eng},
issn = {0028-1298},
journal = {Naunyn-Schmiedebergs Archives of Pharmacology},
title = {Perspectives and challenges of antioxidant therapy for atrial fibrillation},
volume = {390},
year = {2017}
}
TY - JOUR
ID - 1398261
AU - Gasparova, I. - Kubatka, P. - Opatrilova, R. - Caprnda, M. - Filipova, S. - Rodrigo, L. - Malan, L. - Mozos, I. - Rabajdova, M. - Nosal, V. - Kobyliak, N. - Valentova, V. - Petrovic, D. - Adamek, M. - Kružliak, Peter
PY - 2017
TI - Perspectives and challenges of antioxidant therapy for atrial fibrillation
JF - Naunyn-Schmiedebergs Archives of Pharmacology
VL - 390
IS - 1
SP - 1-14
EP - 1-14
PB - Springer
SN - 00281298
KW - Atrial fibrillation
KW - Atrial remodeling
KW - Oxidative stress
KW - Antioxidants
KW - Prevention
KW - Gene therapy
N2 - Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.
ER -
GASPAROVA, I., P. KUBATKA, R. OPATRILOVA, M. CAPRNDA, S. FILIPOVA, L. RODRIGO, L. MALAN, I. MOZOS, M. RABAJDOVA, V. NOSAL, N. KOBYLIAK, V. VALENTOVA, D. PETROVIC, M. ADAMEK a Peter KRUŽLIAK. Perspectives and challenges of antioxidant therapy for atrial fibrillation. \textit{Naunyn-Schmiedebergs Archives of Pharmacology}. New York: Springer, 2017, roč.~390, č.~1, s.~1-14. ISSN~0028-1298. Dostupné z: https://dx.doi.org/10.1007/s00210-016-1320-9.
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