J 2017

C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus

PLESKOVIC, A., M.S. LETONJA, A.C. VUJKOVAC, J.N. STARCEVIC, K. GAZDIKOVA et. al.

Základní údaje

Originální název

C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus

Autoři

PLESKOVIC, A. (705 Slovinsko), M.S. LETONJA (705 Slovinsko), A.C. VUJKOVAC (705 Slovinsko), J.N. STARCEVIC (705 Slovinsko), K. GAZDIKOVA (703 Slovensko), M. CAPRNDA (703 Slovensko), L. GASPAR (703 Slovensko), Peter KRUŽLIAK (703 Slovensko, garant, domácí) a D. PETROVIOC (705 Slovinsko)

Vydání

VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE, BERN, VERLAG HANS HUBER HOGREFE AG, 2017, 0301-1526

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Švýcarsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.210

Kód RIV

RIV/00216224:14110/17:00098634

Organizační jednotka

Lékařská fakulta

UT WoS

000400880500006

Klíčová slova anglicky

Carotid atherosclerosis; inflammation; high sensitive C-reactive protein; prospective study

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 20. 3. 2018 16:47, Soňa Böhmová

Anotace

V originále

Background: This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). Patients and methods: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects, with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP >= 2 mg/L and subjects with hs-CRP below 2 mg/L). Results: Subjects with T2DM and hs-CRP levels a 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT, progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. Conclusions: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.