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@proceedings{1398879,
author = {Nevídalová, Hana and Michalcová, Lenka and Glatz, Zdeněk},
booktitle = {The Biomania Student Scientific Meeting},
keywords = {drug-protein interaction, binding constant, albumin},
language = {eng},
isbn = {978-80-210-8737-8},
title = {Determination of plasma protein-drug binding parameters by using capillary electrophoresis},
url = {http://www.biomania.cz/udalosti-a-akce/biomania-student-scientific-meeting-2017/},
year = {2017}
}
TY - CONF
ID - 1398879
AU - Nevídalová, Hana - Michalcová, Lenka - Glatz, Zdeněk
PY - 2017
TI - Determination of plasma protein-drug binding parameters by using capillary electrophoresis
SN - 9788021087378
KW - drug-protein interaction, binding constant, albumin
UR - http://www.biomania.cz/udalosti-a-akce/biomania-student-scientific-meeting-2017/
N2 - Plasma protein-drug binding is an important parameter, which influence pharmacodynamic and pharmacokinetic properties of the drug. The strength of the binding is commonly described by a binding constant. Bound drug is protected from metabolism and transported by plasma proteins in the blood, but only free drug can provide pharmacological effect. Therefore these interactions are investigated during the early stages of drug development. It is necessary to create easily automated method with possibility of high-throughput screening assay to increase laboratory efficiency.
ER -
NEVÍDALOVÁ, Hana, Lenka MICHALCOVÁ a Zdeněk GLATZ. Determination of plasma protein-drug binding parameters by using capillary electrophoresis. In \textit{The Biomania Student Scientific Meeting}. 2017. ISBN~978-80-210-8737-8.
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