| POSPÍŠIL, Petr, Tomáš KAZDA, Ludmila HYNKOVÁ, Martin BULIK, M. DOBIASKOVA, Petr BURKOŇ, N.N. LAACK, Pavel ŠLAMPA a Radim JANČÁLEK. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology. Barcelona: Elsevier, 2017, roč. 122, č. 3, s. 373-379. ISSN 0167-8140. Dostupné z: https://dx.doi.org/10.1016/j.radonc.2016.12.013. |
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@article{1398895,
author = {Pospíšil, Petr and Kazda, Tomáš and Hynková, Ludmila and Bulik, Martin and Dobiaskova, M. and Burkoň, Petr and Laack, N.N. and Šlampa, Pavel and Jančálek, Radim},
article_location = {Barcelona},
article_number = {3},
doi = {http://dx.doi.org/10.1016/j.radonc.2016.12.013},
keywords = {Hippocampus; Radiation injury; Neurocognitive function; Magnetic resonance spectroscopy},
language = {eng},
issn = {0167-8140},
journal = {Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology},
title = {Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study},
volume = {122},
year = {2017}
}
TY - JOUR
ID - 1398895
AU - Pospíšil, Petr - Kazda, Tomáš - Hynková, Ludmila - Bulik, Martin - Dobiaskova, M. - Burkoň, Petr - Laack, N.N. - Šlampa, Pavel - Jančálek, Radim
PY - 2017
TI - Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study
JF - Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology
VL - 122
IS - 3
SP - 373-379
EP - 373-379
PB - Elsevier
SN - 01678140
KW - Hippocampus
KW - Radiation injury
KW - Neurocognitive function
KW - Magnetic resonance spectroscopy
N2 - Background and purpose: The aim of this prospective study is to evaluate post -whole brain radiotherapy (WBRT) changes in hippocampal concentration of N-acetylaspartate (h-tNAA) as a marker of neuronal loss and to correlate those changes to neurocognitive function. Material and methods: Thirty-five patients with brain metastases underwent baseline single slice multivoxel MR spectroscopy (MRS) examination for measurement of hippocampal h-tNAA together with baseline battery of neurocognitive tests focused on memory (Auditory Verbal Learning Test and Brief Visuospatial Memory Test - Revised) as well as quality of life questionnaires (EORTC QLQ-C30 a EORTC QLQ-BN20). Eighteen patients completed follow-up evaluation four months after standard WBRT (2 laterolateral fields, 10 x 3.0 Gy, 6 MV photons) and were included in this analysis. MRS and cognitive examinations were repeated and compared to baseline measurements. Results: Statistically significant decreases in h-tNAA were observed in the right (8.52-7.42 mM; -12.9%, 95%Cl: -7.6 to -16.4%) as well as in the left hippocampus (8.64-7.60 mM; -12%, 95%Cl: -7.9 to -16.2%). Statistically significant decline was observed in all AVLT and BVMT-R subtests with exception of AVLT_Recognition. Quality of life declined after WBRT (mean Delta-14.1 +/- 20.3 points in transformed 0100 point scale; p = 0.018) with no correlation to changes in hippocampal metabolite concentrations. Moderate positive correlation was observed between left h-tNAA concentration decrease and AVLT_TR decline (r = +0.32; p = 0.24) as well as with AVLT_DR (r = +0.33; p = 0.22) decline. Changes in right htNAA/Cr negatively correlated with AVLT_DR (r = -0.48; p = 0.061). No correlation between right hippocampus h-tNAA and memory decline (AVLT) was observed. Conclusions: Our results suggest hippocampal NAA concentrations decline after WBRT and MRS may be a useful biomarker for monitoring neuronal loss after radiotherapy. 2016 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 122 (2017) 373-379
ER -
POSPÍŠIL, Petr, Tomáš KAZDA, Ludmila HYNKOVÁ, Martin BULIK, M. DOBIASKOVA, Petr BURKOŇ, N.N. LAACK, Pavel ŠLAMPA a Radim JANČÁLEK. Post-WBRT cognitive impairment and hippocampal neuronal depletion measured by in vivo metabolic MR spectroscopy: Results of prospective investigational study. \textit{Radiotherapy and Oncology, Journal of the European Society for Therapeutic Radiology and Oncology}. Barcelona: Elsevier, 2017, roč.~122, č.~3, s.~373-379. ISSN~0167-8140. Dostupné z: https://dx.doi.org/10.1016/j.radonc.2016.12.013.
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