Differential likelihood of NSTEMI vs STEMI in patients with
sleep apnea

J 2017

Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea

LUDKA, Ondřej, Radka ŠTĚPÁNOVÁ, Fatima SERT-KUNIYOSHI, Jindřich ŠPINAR, VK SOMERS et. al.

Základní údaje

Originální název

Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea

Autoři

LUDKA, Ondřej (203 Česká republika, garant, domácí), Radka ŠTĚPÁNOVÁ (203 Česká republika, domácí), Fatima SERT-KUNIYOSHI (840 Spojené státy), Jindřich ŠPINAR (203 Česká republika, domácí), VK SOMERS (203 Česká republika) a Tomáš KÁRA (203 Česká republika)

Vydání

International Journal of Cardiology, Clare (Ireland), Elsevier Ireland Ltd. 2017, 0167-5273

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30201 Cardiac and Cardiovascular systems

Stát vydavatele

Irsko

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 4.034

Kód RIV

RIV/00216224:14110/17:00098746

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ijcard.2017.06.034

UT WoS

000411439900011

Klíčová slova anglicky

Sleep apnea; Non-ST-elevation myocardial infarction; ST-elevation myocardial infarction; Ischemic preconditioning

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 27. 1. 2021 14:27, Mgr. Tereza Miškechová

Anotace

V originále

Background: Sleep apnea (SA) is associated with intermittent hypoxemia that may lead to ischemic preconditioning in the myocardium. This potential cardioprotective effect of SA may play a role in the development of non-ST-elevation myocardial infarction (NSTEMI) versus ST-elevation myocardial infarction (STEMI) during acute ischemia. However, there is limited evidence about the relative prevalence of NSTEMI versus STEMI in SA patients. We therefore prospectively investigated the prevalence of these two types of MI in patients with SA. Methods: We prospectively studied 782 consecutive patients admitted with the diagnosis of acute MI (both NSTEMI and STEMI). All subjects underwent sleep evaluations using a portable diagnostic device after at least 48 h post-admission, provided they were in stable condition. Six hundred and seven out of 782 patients had technically adequate sleep studies, and therefore were included in the final analysis. Results: SA was present in 65.7% (n=399) and NSTEMI in 30% (n=182) of patients. Increasing severity of SA was associated with increasing likelihood of NSTEMI, and with decreasing likelihood of STEMI (p < 0.001). Relative frequency of NSTEMI in the moderate to severe SA group (AHI >= 15 events/h) was 40.6% versus 29.9% for STEMI (p = 0.01). Conclusion: The prevalence of NSTEMI increases with increasing severity of SA. This finding may suggest a cardioprotective role of SA, which may attenuate the development of STEMI, perhaps through ischemic preconditioning. (C) 2017 Published by Elsevier Ireland Ltd.

Návaznosti

LM2015090, projekt VaV

Název: Český národní uzel Evropské sítě infrastruktur klinického výzkumu (Akronym: CZECRIN)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CZECRIN - Český národní uzel Evropské sítě infrastruktur klinického výzkumu

Citovat

LUDKA, Ondřej, Radka ŠTĚPÁNOVÁ, Fatima SERT-KUNIYOSHI, Jindřich ŠPINAR, VK SOMERS a Tomáš KÁRA. Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea. International Journal of Cardiology. Clare (Ireland): Elsevier Ireland Ltd., 2017, roč. 248, DEC 1 2017, s. 64-68. ISSN 0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2017.06.034.

@article{1399056,
   author = {Ludka, Ondřej and Štěpánová, Radka and SertandKuniyoshi, Fatima and Špinar, Jindřich and Somers, VK and Kára, Tomáš},
   article_location = {Clare (Ireland)},
   article_number = {DEC 1 2017},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2017.06.034},
   keywords = {Sleep apnea; Non-ST-elevation myocardial infarction; ST-elevation myocardial infarction; Ischemic preconditioning},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea},
   url = {http://dx.doi.org/10.1016/j.ijcard.2017.06.034},
   volume = {248},
   year = {2017}
}

TY  - JOUR
ID  - 1399056
AU  - Ludka, Ondřej - Štěpánová, Radka - Sert-Kuniyoshi, Fatima - Špinar, Jindřich - Somers, VK - Kára, Tomáš
PY  - 2017
TI  - Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea
JF  - International Journal of Cardiology
VL  - 248
IS  - DEC 1 2017
SP  - 64-68
EP  - 64-68
PB  - Elsevier Ireland Ltd.
SN  - 01675273
KW  - Sleep apnea
KW  - Non-ST-elevation myocardial infarction
KW  - ST-elevation myocardial infarction
KW  - Ischemic preconditioning
UR  - http://dx.doi.org/10.1016/j.ijcard.2017.06.034
L2  - http://dx.doi.org/10.1016/j.ijcard.2017.06.034
N2  - Background: Sleep apnea (SA) is associated with intermittent hypoxemia that may lead to ischemic preconditioning in the myocardium. This potential cardioprotective effect of SA may play a role in the development of non-ST-elevation myocardial infarction (NSTEMI) versus ST-elevation myocardial infarction (STEMI) during acute ischemia. However, there is limited evidence about the relative prevalence of NSTEMI versus STEMI in SA patients. We therefore prospectively investigated the prevalence of these two types of MI in patients with SA. Methods: We prospectively studied 782 consecutive patients admitted with the diagnosis of acute MI (both NSTEMI and STEMI). All subjects underwent sleep evaluations using a portable diagnostic device after at least 48 h post-admission, provided they were in stable condition. Six hundred and seven out of 782 patients had technically adequate sleep studies, and therefore were included in the final analysis. Results: SA was present in 65.7% (n=399) and NSTEMI in 30% (n=182) of patients. Increasing severity of SA was associated with increasing likelihood of NSTEMI, and with decreasing likelihood of STEMI (p < 0.001). Relative frequency of NSTEMI in the moderate to severe SA group (AHI >= 15 events/h) was 40.6% versus 29.9% for STEMI (p = 0.01). Conclusion: The prevalence of NSTEMI increases with increasing severity of SA. This finding may suggest a cardioprotective role of SA, which may attenuate the development of STEMI, perhaps through ischemic preconditioning. (C) 2017 Published by Elsevier Ireland Ltd.
ER  -

LUDKA, Ondřej, Radka ŠTĚPÁNOVÁ, Fatima SERT-KUNIYOSHI, Jindřich ŠPINAR, VK SOMERS a Tomáš KÁRA. Differential likelihood of NSTEMI vs STEMI in patients with sleep apnea. \textit{International Journal of Cardiology}. Clare (Ireland): Elsevier Ireland Ltd., 2017, roč.~248, DEC 1 2017, s.~64-68. ISSN~0167-5273. Dostupné z: https://dx.doi.org/10.1016/j.ijcard.2017.06.034.

Podrobný výpis o publikaci