2018
Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes
PAVLOVÁ, Tereza, Filip ZLÁMAL, Zbyněk ŠPLÍCHAL, Josef TOMANDL, Zuzana HODICKÁ et. al.Základní údaje
Originální název
Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes
Autoři
PAVLOVÁ, Tereza (203 Česká republika, garant, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Zbyněk ŠPLÍCHAL (203 Česká republika, domácí), Josef TOMANDL (203 Česká republika, domácí), Zuzana HODICKÁ (203 Česká republika), Pavel VENTRUBA (203 Česká republika) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí)
Vydání
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
30214 Obstetrics and gynaecology
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 1.569
Kód RIV
RIV/00216224:14110/18:00102133
Organizační jednotka
Lékařská fakulta
UT WoS
000430732700001
Klíčová slova anglicky
Visfatin; PBEF; NAMPT; preterm birth; preterm premature rupture of membranes
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 26. 3. 2019 10:35, Soňa Böhmová
Anotace
V originále
Objectives: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within seven days and after more than seven days following admission for PTB/preterm premature rupture of membranes (PPROMs).Methods: Maternal peripheral blood and cord blood were collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (three with PPROM).Results: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p=.021) and also in mothers who delivered within seven days after admission for PTB or PPROM, compared to those who delivered after more than seven days (p=.027; p=.039). Cord blood visfatin concentration was found to be decreased in preterm compared to term infants (p=.007).Conclusions: Visfatin in both maternal and fetal circulation may play an important role in the pathogenesis of PTB/PPROM and could be used to distinguish between women who will deliver in a short period of time after clinical presentation of PTB/PPROM and those who deliver later. Nevertheless, additional research is necessary in order to identify its direct involvement in PTB/PPROM.
Návaznosti
EF15_003/0000469, projekt VaV |
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LM2015051, projekt VaV |
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