Comparison of maternal omentin-1 levels and genetic variability
between spontaneous term and preterm births

J 2018

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

ŠPLÍCHAL, Zbyněk; Filip ZLÁMAL; Jan MÁCHAL; Jolana LIPKOVÁ; Tereza PAVLOVÁ et. al.

Základní údaje

Originální název

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

Autoři

ŠPLÍCHAL, Zbyněk (203 Česká republika, garant, domácí); Filip ZLÁMAL (203 Česká republika, domácí); Jan MÁCHAL (203 Česká republika, domácí); Jolana LIPKOVÁ (203 Česká republika, domácí); Tereza PAVLOVÁ (203 Česká republika, domácí); Zuzana HODICKÁ (203 Česká republika); Pavel VENTRUBA (203 Česká republika); Anna VAŠKŮ (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí)

Vydání

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.569

Kód RIV

RIV/00216224:14110/18:00102134

Organizační jednotka

Lékařská fakulta

DOI

https://doi.org/10.1080/14767058.2017.1323530

UT WoS

000430732400003

EID Scopus

2-s2.0-85019214172

Klíčová slova anglicky

Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM

Štítky

14110518, EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2019 10:44, Soňa Böhmová

Anotace

V originále

Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

ŠPLÍCHAL, Zbyněk; Filip ZLÁMAL; Jan MÁCHAL; Jolana LIPKOVÁ; Tereza PAVLOVÁ; Zuzana HODICKÁ; Pavel VENTRUBA; Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. LONDON: INFORMA HEALTHCARE, 2018, roč. 31, č. 13, s. 1689-1695. ISSN 1476-7058. Dostupné z: https://doi.org/10.1080/14767058.2017.1323530.

@article{1399109,
   author = {Šplíchal, Zbyněk and Zlámal, Filip and Máchal, Jan and Lipková, Jolana and Pavlová, Tereza and Hodická, Zuzana and Ventruba, Pavel and Vašků, Anna and Bienertová Vašků, Julie},
   article_location = {LONDON},
   article_number = {13},
   doi = {https://doi.org/10.1080/14767058.2017.1323530},
   keywords = {Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM},
   language = {eng},
   issn = {1476-7058},
   journal = {JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE},
   title = {Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births},
   volume = {31},
   year = {2018}
}

TY  - JOUR
ID  - 1399109
AU  - Šplíchal, Zbyněk - Zlámal, Filip - Máchal, Jan - Lipková, Jolana - Pavlová, Tereza - Hodická, Zuzana - Ventruba, Pavel - Vašků, Anna - Bienertová Vašků, Julie
PY  - 2018
TI  - Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
JF  - JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
VL  - 31
IS  - 13
SP  - 1689-1695
EP  - 1689-1695
PB  - INFORMA HEALTHCARE
SN  - 14767058
KW  - Omentin-1
KW  - adipokine
KW  - preterm birth
KW  - Val109Asp polymorphism
KW  - PPROM
N2  - Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
ER  -

ŠPLÍCHAL, Zbyněk; Filip ZLÁMAL; Jan MÁCHAL; Jolana LIPKOVÁ; Tereza PAVLOVÁ; Zuzana HODICKÁ; Pavel VENTRUBA; Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. \textit{JOURNAL OF MATERNAL-FETAL \&{}amp; NEONATAL MEDICINE}. LONDON: INFORMA HEALTHCARE, 2018, roč.~31, č.~13, s.~1689-1695. ISSN~1476-7058. Dostupné z: https://doi.org/10.1080/14767058.2017.1323530.

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