Comparison of maternal omentin-1 levels and genetic variability
between spontaneous term and preterm births

J 2018

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ et. al.

Základní údaje

Originální název

Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births

Autoři

ŠPLÍCHAL, Zbyněk (203 Česká republika, garant, domácí), Filip ZLÁMAL (203 Česká republika, domácí), Jan MÁCHAL (203 Česká republika, domácí), Jolana LIPKOVÁ (203 Česká republika, domácí), Tereza PAVLOVÁ (203 Česká republika, domácí), Zuzana HODICKÁ (203 Česká republika), Pavel VENTRUBA (203 Česká republika), Anna VAŠKŮ (203 Česká republika, domácí) a Julie BIENERTOVÁ VAŠKŮ (203 Česká republika, domácí)

Vydání

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE, LONDON, INFORMA HEALTHCARE, 2018, 1476-7058

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30214 Obstetrics and gynaecology

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.569

Kód RIV

RIV/00216224:14110/18:00102134

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1080/14767058.2017.1323530

UT WoS

000430732400003

Klíčová slova anglicky

Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM

Štítky

14110518, EL OK, podil, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 26. 3. 2019 10:44, Soňa Böhmová

Anotace

V originále

Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.

Návaznosti

EF15_003/0000469, projekt VaV

Název: Cetocoen Plus

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

Citovat

ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ, Zuzana HODICKÁ, Pavel VENTRUBA, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. LONDON: INFORMA HEALTHCARE, 2018, roč. 31, č. 13, s. 1689-1695. ISSN 1476-7058. Dostupné z: https://dx.doi.org/10.1080/14767058.2017.1323530.

@article{1399109,
   author = {Šplíchal, Zbyněk and Zlámal, Filip and Máchal, Jan and Lipková, Jolana and Pavlová, Tereza and Hodická, Zuzana and Ventruba, Pavel and Vašků, Anna and Bienertová Vašků, Julie},
   article_location = {LONDON},
   article_number = {13},
   doi = {http://dx.doi.org/10.1080/14767058.2017.1323530},
   keywords = {Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM},
   language = {eng},
   issn = {1476-7058},
   journal = {JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE},
   title = {Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births},
   volume = {31},
   year = {2018}
}

TY  - JOUR
ID  - 1399109
AU  - Šplíchal, Zbyněk - Zlámal, Filip - Máchal, Jan - Lipková, Jolana - Pavlová, Tereza - Hodická, Zuzana - Ventruba, Pavel - Vašků, Anna - Bienertová Vašků, Julie
PY  - 2018
TI  - Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
JF  - JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
VL  - 31
IS  - 13
SP  - 1689-1695
EP  - 1689-1695
PB  - INFORMA HEALTHCARE
SN  - 14767058
KW  - Omentin-1
KW  - adipokine
KW  - preterm birth
KW  - Val109Asp polymorphism
KW  - PPROM
N2  - Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
ER  -

ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ, Zuzana HODICKÁ, Pavel VENTRUBA, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. \textit{JOURNAL OF MATERNAL-FETAL \&{}amp; NEONATAL MEDICINE}. LONDON: INFORMA HEALTHCARE, 2018, roč.~31, č.~13, s.~1689-1695. ISSN~1476-7058. Dostupné z: https://dx.doi.org/10.1080/14767058.2017.1323530.

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