| ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ, Zuzana HODICKÁ, Pavel VENTRUBA, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE. LONDON: INFORMA HEALTHCARE, 2018, roč. 31, č. 13, s. 1689-1695. ISSN 1476-7058. Dostupné z: https://dx.doi.org/10.1080/14767058.2017.1323530. |
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@article{1399109,
author = {Šplíchal, Zbyněk and Zlámal, Filip and Máchal, Jan and Lipková, Jolana and Pavlová, Tereza and Hodická, Zuzana and Ventruba, Pavel and Vašků, Anna and Bienertová Vašků, Julie},
article_location = {LONDON},
article_number = {13},
doi = {http://dx.doi.org/10.1080/14767058.2017.1323530},
keywords = {Omentin-1; adipokine; preterm birth; Val109Asp polymorphism; PPROM},
language = {eng},
issn = {1476-7058},
journal = {JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE},
title = {Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births},
volume = {31},
year = {2018}
}
TY - JOUR
ID - 1399109
AU - Šplíchal, Zbyněk - Zlámal, Filip - Máchal, Jan - Lipková, Jolana - Pavlová, Tereza - Hodická, Zuzana - Ventruba, Pavel - Vašků, Anna - Bienertová Vašků, Julie
PY - 2018
TI - Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births
JF - JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
VL - 31
IS - 13
SP - 1689-1695
EP - 1689-1695
PB - INFORMA HEALTHCARE
SN - 14767058
KW - Omentin-1
KW - adipokine
KW - preterm birth
KW - Val109Asp polymorphism
KW - PPROM
N2 - Objective: To determine maternal omentin-1 levels and genetic variability in the omentin-1 gene in women with spontaneous term and preterm births (PTBs).Materials and methods: Maternal serum omentin-1 levels and the role of the omentin-1 Val109Asp (rs2274907) polymorphism were evaluated in 32 women with spontaneous term birth (sTB) and 30 women with spontaneous preterm birth (sPTB) including women with (n=16) and without (n=14) preterm premature rupture of membranes (PPROM).Results: Maternal omentin-1 levels were significantly lower in women with sPTBs compared to term births during the hospitalization period (p=.015). However, maternal omentin-1 levels were similar in women with sPTBs with and without PPROM (p=.990). Furthermore, the omentin-1 Val109Asp polymorphism was found to have no significant effect on omentin-1 serum levels. In addition, no significant differences in genotype distributions and allelic frequencies between sTB and sPTB were established.Conclusions: High omentin-1 levels in normal sTBs compared to PTBs without significant differences between cases with and without PPROM suggest that omentin-1 plays a potential role in the pathophysiology of PTB but not in the PPROM mechanism itself.
ER -
ŠPLÍCHAL, Zbyněk, Filip ZLÁMAL, Jan MÁCHAL, Jolana LIPKOVÁ, Tereza PAVLOVÁ, Zuzana HODICKÁ, Pavel VENTRUBA, Anna VAŠKŮ a Julie BIENERTOVÁ VAŠKŮ. Comparison of maternal omentin-1 levels and genetic variability between spontaneous term and preterm births. \textit{JOURNAL OF MATERNAL-FETAL \&{}amp; NEONATAL MEDICINE}. LONDON: INFORMA HEALTHCARE, 2018, roč.~31, č.~13, s.~1689-1695. ISSN~1476-7058. Dostupné z: https://dx.doi.org/10.1080/14767058.2017.1323530.
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