Disruption in Cerebellar and Basal Ganglia Networks During a
Visuospatial Task in Cervical Dystonia

J 2017

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA et. al.

Základní údaje

Originální název

Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia

Autoři

FILIP, Pavel (703 Slovensko, garant, domácí), C. GALLEA (250 Francie), S. LEHERICY (250 Francie), E. BERTASI (250 Francie), T. POPA (250 Francie), Radek MAREČEK (203 Česká republika, domácí), O.V. LUNGU (124 Kanada), Tomáš KAŠPÁREK (203 Česká republika, domácí), Jiří VANÍČEK (203 Česká republika, domácí) a Martin BAREŠ (203 Česká republika, domácí)

Vydání

Movement Disorders, HOBOKEN, WILEY, 2017, 0885-3185

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 8.324

Kód RIV

RIV/00216224:14110/17:00098773

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/mds.26930

UT WoS

000401936200018

Klíčová slova anglicky

cervical dystonia; cerebellum; basal ganglia; fMRI; functional connectivity

Štítky

EL OK, podil

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 18:57, Soňa Böhmová

Anotace

V originále

Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society

Návaznosti

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA, Radek MAREČEK, O.V. LUNGU, Tomáš KAŠPÁREK, Jiří VANÍČEK a Martin BAREŠ. Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia. Movement Disorders. HOBOKEN: WILEY, 2017, roč. 32, č. 5, s. 757-768. ISSN 0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.26930.

@article{1399126,
   author = {Filip, Pavel and Gallea, C. and Lehericy, S. and Bertasi, E. and Popa, T. and Mareček, Radek and Lungu, O.V. and Kašpárek, Tomáš and Vaníček, Jiří and Bareš, Martin},
   article_location = {HOBOKEN},
   article_number = {5},
   doi = {http://dx.doi.org/10.1002/mds.26930},
   keywords = {cervical dystonia; cerebellum; basal ganglia; fMRI; functional connectivity},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1399126
AU  - Filip, Pavel - Gallea, C. - Lehericy, S. - Bertasi, E. - Popa, T. - Mareček, Radek - Lungu, O.V. - Kašpárek, Tomáš - Vaníček, Jiří - Bareš, Martin
PY  - 2017
TI  - Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia
JF  - Movement Disorders
VL  - 32
IS  - 5
SP  - 757-768
EP  - 757-768
PB  - WILEY
SN  - 08853185
KW  - cervical dystonia
KW  - cerebellum
KW  - basal ganglia
KW  - fMRI
KW  - functional connectivity
N2  - Background: Although dystonia is traditionally conceptualized as a basal ganglia disorder, increasing interest has been directed at a different neural network node, the cerebellum, which may play a significant role in the pathophysiology of dystonia. Abnormal sensorimotor processing and disturbed motor schemes, possibly attributable to cerebellar changes, remain unclear. Methods: We sought to characterize the extent of cerebellar dysfunction within the motor network using functional MRI activation analysis, connectivity analysis, and voxel-based morphometry in cervical dystonia patients ( n525, 15 women, mean age 45.8 years) and healthy volunteers ( n525, 15 women, mean age 44.7 years) in a visuospatial task requiring predictive motor timing. Results: Cervical dystonia patients showed decreased activation in the posterior cerebellar lobules as well as in the premotor areas, the associative parietal cortex, and visual regions. Patients also had decreased cerebellar connectivity with bilateral basal ganglia structures and the dorsolateral prefrontal cortex. Conclusions: This promotes the view that dystonia results from miscommunication between the basal ganglia and cerebellar loops, thus providing new insights into the brain regions essential for the development of cervical dystonia. (C) 2017 International Parkinson and Movement Disorder Society
ER  -

FILIP, Pavel, C. GALLEA, S. LEHERICY, E. BERTASI, T. POPA, Radek MAREČEK, O.V. LUNGU, Tomáš KAŠPÁREK, Jiří VANÍČEK a Martin BAREŠ. Disruption in Cerebellar and Basal Ganglia Networks During a Visuospatial Task in Cervical Dystonia. \textit{Movement Disorders}. HOBOKEN: WILEY, 2017, roč.~32, č.~5, s.~757-768. ISSN~0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.26930.

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