Intertumoral Heterogeneity within Medulloblastoma Subgroups

J 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups

CAVALLI, F.M.G., M. REMKE, L. RAMPASEK, J. PEACOCK, D.J.H. SHIH et. al.

Základní údaje

Originální název

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Autoři

CAVALLI, F.M.G. (124 Kanada), M. REMKE (124 Kanada), L. RAMPASEK (124 Kanada), J. PEACOCK (124 Kanada), D.J.H. SHIH (124 Kanada), B. LUU (124 Kanada), L. GARZIA (124 Kanada), J. TORCHIA (124 Kanada), C. NOR (124 Kanada), A.S. MORRISSY (124 Kanada), S. AGNIHOTRI (840 Spojené státy), Y.Y. THOMPSON (124 Kanada), C.M. KUZAN-FISCHER (124 Kanada), H. FAROOQ (124 Kanada), K. ISAEV (124 Kanada), C. DANIELS (124 Kanada), B.K. CHO (410 Korejská republika), S.K. KIM (410 Korejská republika), K.C. WANG (410 Korejská republika), J.Y. LEE (410 Korejská republika), W.A. GRAJKOWSKA (840 Spojené státy), M. PEREK-POLNIK (616 Polsko), A. VASILJEVIC (250 Francie), C. FAURE-CONTER (250 Francie), A. JOUVET (250 Francie), C. GIANNINI (840 Spojené státy), A.A.N. RAO (840 Spojené státy), K.K.W. LI (156 Čína), H.K. NG (156 Čína), C.G. EBERHART (840 Spojené státy), I.F. POLLACK (840 Spojené státy), R.L. HAMILTON (840 Spojené státy), G.Y. GILLESPIE (840 Spojené státy), J.M. OLSON (840 Spojené státy), S. LEARY (840 Spojené státy), W.A. WEISS (840 Spojené státy), B. LACH (124 Kanada), L.B. CHAMBLESS (840 Spojené státy), R.C. THOMPSON (840 Spojené státy), M.K. COOPER (840 Spojené státy), R. VIBHAKAR (840 Spojené státy), P. HAUSER (348 Maďarsko), M.L.C. van VEELEN (528 Nizozemské království), J.M. KROS (528 Nizozemské království), P.J. FRENCH (528 Nizozemské království), Y.S. RA (410 Korejská republika), T. KUMABE (392 Japonsko), E. LOPEZ-AGUILAR (484 Mexiko), Karel ZITTERBART (203 Česká republika, domácí), Jaroslav ŠTĚRBA (203 Česká republika, garant, domácí), G. FINOCCHIARO (380 Itálie), M. MASSIMINO (380 Itálie), E.G. VAN MEIR (840 Spojené státy), S. OSUKA (840 Spojené státy), T. SHOFUDA (392 Japonsko), A. KLEKNER (348 Maďarsko), M. ZOLLO (380 Itálie), J.R. LEONARD (840 Spojené státy), J.B. RUBIN (840 Spojené státy), N. JABADO (124 Kanada), S. ALBRECHT (124 Kanada), J. MORA (724 Španělsko), T.E. VAN METER (840 Spojené státy), S. JUNG (410 Korejská republika), A.S. MOORE (36 Austrálie), A.R. HALLAHAN (36 Austrálie), J.A. CHAN (124 Kanada), D.C. TIRAPELI (76 Brazílie), C.G. CARLOTTO (76 Brazílie), M. FOULADI (840 Spojené státy), J. PIMENTEL (620 Portugalsko), C.C. FARIA (620 Portugalsko), A.G. SAAD (840 Spojené státy), L. MASSIMI (380 Itálie), L.M. LIAU (840 Spojené státy), H. WHEELER (36 Austrálie), H. NAKAMURA (392 Japonsko), S.K. ELBABAA (840 Spojené státy), M. PEREZPENA DIAZCONTI (484 Mexiko), F.C. PONCE DE LEÓN (484 Mexiko), S. ROBINSON (840 Spojené státy), M. ZAPOTOCKY (124 Kanada), A. LASSALETTA (124 Kanada), A. HUANG (124 Kanada), C.E. HAWKINS (124 Kanada), U. TABORI (124 Kanada), E. BOUFFET (124 Kanada), U. BARTELS (124 Kanada), P.B. DIRKS (124 Kanada), J.T. RUTKA (124 Kanada), G.D. BADER (124 Kanada), J. REIMAND (124 Kanada), A. GOLDENBERG (124 Kanada), V. RAMASWAMY (124 Kanada) a M.D. TAYLOR (124 Kanada)

Vydání

Cancer Cell, Cambridge, Cell Press, 2017, 1535-6108

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30204 Oncology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 22.844

Kód RIV

RIV/00216224:14110/17:00098842

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.ccell.2017.05.005

UT WoS

000403074800005

Klíčová slova anglicky

Intertumoral Heterogeneity

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 15:07, Soňa Böhmová

Anotace

V originále

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Návaznosti

EE2.3.20.0183, projekt VaV

Název: Centrum experimentální biomedicíny

Citovat

CAVALLI, F.M.G., M. REMKE, L. RAMPASEK, J. PEACOCK, D.J.H. SHIH, B. LUU, L. GARZIA, J. TORCHIA, C. NOR, A.S. MORRISSY, S. AGNIHOTRI, Y.Y. THOMPSON, C.M. KUZAN-FISCHER, H. FAROOQ, K. ISAEV, C. DANIELS, B.K. CHO, S.K. KIM, K.C. WANG, J.Y. LEE, W.A. GRAJKOWSKA, M. PEREK-POLNIK, A. VASILJEVIC, C. FAURE-CONTER, A. JOUVET, C. GIANNINI, A.A.N. RAO, K.K.W. LI, H.K. NG, C.G. EBERHART, I.F. POLLACK, R.L. HAMILTON, G.Y. GILLESPIE, J.M. OLSON, S. LEARY, W.A. WEISS, B. LACH, L.B. CHAMBLESS, R.C. THOMPSON, M.K. COOPER, R. VIBHAKAR, P. HAUSER, M.L.C. van VEELEN, J.M. KROS, P.J. FRENCH, Y.S. RA, T. KUMABE, E. LOPEZ-AGUILAR, Karel ZITTERBART, Jaroslav ŠTĚRBA, G. FINOCCHIARO, M. MASSIMINO, E.G. VAN MEIR, S. OSUKA, T. SHOFUDA, A. KLEKNER, M. ZOLLO, J.R. LEONARD, J.B. RUBIN, N. JABADO, S. ALBRECHT, J. MORA, T.E. VAN METER, S. JUNG, A.S. MOORE, A.R. HALLAHAN, J.A. CHAN, D.C. TIRAPELI, C.G. CARLOTTO, M. FOULADI, J. PIMENTEL, C.C. FARIA, A.G. SAAD, L. MASSIMI, L.M. LIAU, H. WHEELER, H. NAKAMURA, S.K. ELBABAA, M. PEREZPENA DIAZCONTI, F.C. PONCE DE LEÓN, S. ROBINSON, M. ZAPOTOCKY, A. LASSALETTA, A. HUANG, C.E. HAWKINS, U. TABORI, E. BOUFFET, U. BARTELS, P.B. DIRKS, J.T. RUTKA, G.D. BADER, J. REIMAND, A. GOLDENBERG, V. RAMASWAMY a M.D. TAYLOR. Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. Cambridge: Cell Press, 2017, roč. 31, č. 6, s. "737"-"+", 24 s. ISSN 1535-6108. Dostupné z: https://dx.doi.org/10.1016/j.ccell.2017.05.005.

@article{1399418,
   author = {Cavalli, F.M.G. and Remke, M. and Rampasek, L. and Peacock, J. and Shih, D.J.H. and Luu, B. and Garzia, L. and Torchia, J. and Nor, C. and Morrissy, A.S. and Agnihotri, S. and Thompson, Y.Y. and KuzanandFischer, C.M. and Farooq, H. and Isaev, K. and Daniels, C. and Cho, B.K. and Kim, S.K. and Wang, K.C. and Lee, J.Y. and Grajkowska, W.A. and PerekandPolnik, M. and Vasiljevic, A. and FaureandConter, C. and Jouvet, A. and Giannini, C. and Rao, A.A.N. and Li, K.K.W. and Ng, H.K. and Eberhart, C.G. and Pollack, I.F. and Hamilton, R.L. and Gillespie, G.Y. and Olson, J.M. and Leary, S. and Weiss, W.A. and Lach, B. and Chambless, L.B. and Thompson, R.C. and Cooper, M.K. and Vibhakar, R. and Hauser, P. and Veelen, M.L.C. van and Kros, J.M. and French, P.J. and Ra, Y.S. and Kumabe, T. and LopezandAguilar, E. and Zitterbart, Karel and Štěrba, Jaroslav and Finocchiaro, G. and Massimino, M. and Van Meir, E.G. and Osuka, S. and Shofuda, T. and Klekner, A. and Zollo, M. and Leonard, J.R. and Rubin, J.B. and Jabado, N. and Albrecht, S. and Mora, J. and Van Meter, T.E. and Jung, S. and Moore, A.S. and Hallahan, A.R. and Chan, J.A. and Tirapeli, D.C. and Carlotto, C.G. and Fouladi, M. and Pimentel, J. and Faria, C.C. and Saad, A.G. and Massimi, L. and Liau, L.M. and Wheeler, H. and Nakamura, H. and Elbabaa, S.K. and Perezpena Diazconti, M. and Ponce de León, F.C. and Robinson, S. and Zapotocky, M. and Lassaletta, A. and Huang, A. and Hawkins, C.E. and Tabori, U. and Bouffet, E. and Bartels, U. and Dirks, P.B. and Rutka, J.T. and Bader, G.D. and Reimand, J. and Goldenberg, A. and Ramaswamy, V. and Taylor, M.D.},
   article_location = {Cambridge},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.ccell.2017.05.005},
   keywords = {Intertumoral Heterogeneity},
   language = {eng},
   issn = {1535-6108},
   journal = {Cancer Cell},
   title = {Intertumoral Heterogeneity within Medulloblastoma Subgroups},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1399418
AU  - Cavalli, F.M.G. - Remke, M. - Rampasek, L. - Peacock, J. - Shih, D.J.H. - Luu, B. - Garzia, L. - Torchia, J. - Nor, C. - Morrissy, A.S. - Agnihotri, S. - Thompson, Y.Y. - Kuzan-Fischer, C.M. - Farooq, H. - Isaev, K. - Daniels, C. - Cho, B.K. - Kim, S.K. - Wang, K.C. - Lee, J.Y. - Grajkowska, W.A. - Perek-Polnik, M. - Vasiljevic, A. - Faure-Conter, C. - Jouvet, A. - Giannini, C. - Rao, A.A.N. - Li, K.K.W. - Ng, H.K. - Eberhart, C.G. - Pollack, I.F. - Hamilton, R.L. - Gillespie, G.Y. - Olson, J.M. - Leary, S. - Weiss, W.A. - Lach, B. - Chambless, L.B. - Thompson, R.C. - Cooper, M.K. - Vibhakar, R. - Hauser, P. - Veelen, M.L.C. van - Kros, J.M. - French, P.J. - Ra, Y.S. - Kumabe, T. - Lopez-Aguilar, E. - Zitterbart, Karel - Štěrba, Jaroslav - Finocchiaro, G. - Massimino, M. - Van Meir, E.G. - Osuka, S. - Shofuda, T. - Klekner, A. - Zollo, M. - Leonard, J.R. - Rubin, J.B. - Jabado, N. - Albrecht, S. - Mora, J. - Van Meter, T.E. - Jung, S. - Moore, A.S. - Hallahan, A.R. - Chan, J.A. - Tirapeli, D.C. - Carlotto, C.G. - Fouladi, M. - Pimentel, J. - Faria, C.C. - Saad, A.G. - Massimi, L. - Liau, L.M. - Wheeler, H. - Nakamura, H. - Elbabaa, S.K. - Perezpena Diazconti, M. - Ponce de León, F.C. - Robinson, S. - Zapotocky, M. - Lassaletta, A. - Huang, A. - Hawkins, C.E. - Tabori, U. - Bouffet, E. - Bartels, U. - Dirks, P.B. - Rutka, J.T. - Bader, G.D. - Reimand, J. - Goldenberg, A. - Ramaswamy, V. - Taylor, M.D.
PY  - 2017
TI  - Intertumoral Heterogeneity within Medulloblastoma Subgroups
JF  - Cancer Cell
VL  - 31
IS  - 6
SP  - "737"-"+"
EP  - "737"-"+"
PB  - Cell Press
SN  - 15356108
KW  - Intertumoral Heterogeneity
N2  - While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
ER  -

CAVALLI, F.M.G., M. REMKE, L. RAMPASEK, J. PEACOCK, D.J.H. SHIH, B. LUU, L. GARZIA, J. TORCHIA, C. NOR, A.S. MORRISSY, S. AGNIHOTRI, Y.Y. THOMPSON, C.M. KUZAN-FISCHER, H. FAROOQ, K. ISAEV, C. DANIELS, B.K. CHO, S.K. KIM, K.C. WANG, J.Y. LEE, W.A. GRAJKOWSKA, M. PEREK-POLNIK, A. VASILJEVIC, C. FAURE-CONTER, A. JOUVET, C. GIANNINI, A.A.N. RAO, K.K.W. LI, H.K. NG, C.G. EBERHART, I.F. POLLACK, R.L. HAMILTON, G.Y. GILLESPIE, J.M. OLSON, S. LEARY, W.A. WEISS, B. LACH, L.B. CHAMBLESS, R.C. THOMPSON, M.K. COOPER, R. VIBHAKAR, P. HAUSER, M.L.C. van VEELEN, J.M. KROS, P.J. FRENCH, Y.S. RA, T. KUMABE, E. LOPEZ-AGUILAR, Karel ZITTERBART, Jaroslav ŠTĚRBA, G. FINOCCHIARO, M. MASSIMINO, E.G. VAN MEIR, S. OSUKA, T. SHOFUDA, A. KLEKNER, M. ZOLLO, J.R. LEONARD, J.B. RUBIN, N. JABADO, S. ALBRECHT, J. MORA, T.E. VAN METER, S. JUNG, A.S. MOORE, A.R. HALLAHAN, J.A. CHAN, D.C. TIRAPELI, C.G. CARLOTTO, M. FOULADI, J. PIMENTEL, C.C. FARIA, A.G. SAAD, L. MASSIMI, L.M. LIAU, H. WHEELER, H. NAKAMURA, S.K. ELBABAA, M. PEREZPENA DIAZCONTI, F.C. PONCE DE LEÓN, S. ROBINSON, M. ZAPOTOCKY, A. LASSALETTA, A. HUANG, C.E. HAWKINS, U. TABORI, E. BOUFFET, U. BARTELS, P.B. DIRKS, J.T. RUTKA, G.D. BADER, J. REIMAND, A. GOLDENBERG, V. RAMASWAMY a M.D. TAYLOR. Intertumoral Heterogeneity within Medulloblastoma Subgroups. \textit{Cancer Cell}. Cambridge: Cell Press, 2017, roč.~31, č.~6, s.~''737''-''+'', 24 s. ISSN~1535-6108. Dostupné z: https://dx.doi.org/10.1016/j.ccell.2017.05.005.

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