Intertumoral Heterogeneity within Medulloblastoma Subgroups

J 2017

Intertumoral Heterogeneity within Medulloblastoma Subgroups

CAVALLI, F.M.G., M. REMKE, L. RAMPASEK, J. PEACOCK, D.J.H. SHIH et. al.

Basic information

Original name

Intertumoral Heterogeneity within Medulloblastoma Subgroups

Authors

CAVALLI, F.M.G. (124 Canada), M. REMKE (124 Canada), L. RAMPASEK (124 Canada), J. PEACOCK (124 Canada), D.J.H. SHIH (124 Canada), B. LUU (124 Canada), L. GARZIA (124 Canada), J. TORCHIA (124 Canada), C. NOR (124 Canada), A.S. MORRISSY (124 Canada), S. AGNIHOTRI (840 United States of America), Y.Y. THOMPSON (124 Canada), C.M. KUZAN-FISCHER (124 Canada), H. FAROOQ (124 Canada), K. ISAEV (124 Canada), C. DANIELS (124 Canada), B.K. CHO (410 Republic of Korea), S.K. KIM (410 Republic of Korea), K.C. WANG (410 Republic of Korea), J.Y. LEE (410 Republic of Korea), W.A. GRAJKOWSKA (840 United States of America), M. PEREK-POLNIK (616 Poland), A. VASILJEVIC (250 France), C. FAURE-CONTER (250 France), A. JOUVET (250 France), C. GIANNINI (840 United States of America), A.A.N. RAO (840 United States of America), K.K.W. LI (156 China), H.K. NG (156 China), C.G. EBERHART (840 United States of America), I.F. POLLACK (840 United States of America), R.L. HAMILTON (840 United States of America), G.Y. GILLESPIE (840 United States of America), J.M. OLSON (840 United States of America), S. LEARY (840 United States of America), W.A. WEISS (840 United States of America), B. LACH (124 Canada), L.B. CHAMBLESS (840 United States of America), R.C. THOMPSON (840 United States of America), M.K. COOPER (840 United States of America), R. VIBHAKAR (840 United States of America), P. HAUSER (348 Hungary), M.L.C. van VEELEN (528 Netherlands), J.M. KROS (528 Netherlands), P.J. FRENCH (528 Netherlands), Y.S. RA (410 Republic of Korea), T. KUMABE (392 Japan), E. LOPEZ-AGUILAR (484 Mexico), Karel ZITTERBART (203 Czech Republic, belonging to the institution), Jaroslav ŠTĚRBA (203 Czech Republic, guarantor, belonging to the institution), G. FINOCCHIARO (380 Italy), M. MASSIMINO (380 Italy), E.G. VAN MEIR (840 United States of America), S. OSUKA (840 United States of America), T. SHOFUDA (392 Japan), A. KLEKNER (348 Hungary), M. ZOLLO (380 Italy), J.R. LEONARD (840 United States of America), J.B. RUBIN (840 United States of America), N. JABADO (124 Canada), S. ALBRECHT (124 Canada), J. MORA (724 Spain), T.E. VAN METER (840 United States of America), S. JUNG (410 Republic of Korea), A.S. MOORE (36 Australia), A.R. HALLAHAN (36 Australia), J.A. CHAN (124 Canada), D.C. TIRAPELI (76 Brazil), C.G. CARLOTTO (76 Brazil), M. FOULADI (840 United States of America), J. PIMENTEL (620 Portugal), C.C. FARIA (620 Portugal), A.G. SAAD (840 United States of America), L. MASSIMI (380 Italy), L.M. LIAU (840 United States of America), H. WHEELER (36 Australia), H. NAKAMURA (392 Japan), S.K. ELBABAA (840 United States of America), M. PEREZPENA DIAZCONTI (484 Mexico), F.C. PONCE DE LEÓN (484 Mexico), S. ROBINSON (840 United States of America), M. ZAPOTOCKY (124 Canada), A. LASSALETTA (124 Canada), A. HUANG (124 Canada), C.E. HAWKINS (124 Canada), U. TABORI (124 Canada), E. BOUFFET (124 Canada), U. BARTELS (124 Canada), P.B. DIRKS (124 Canada), J.T. RUTKA (124 Canada), G.D. BADER (124 Canada), J. REIMAND (124 Canada), A. GOLDENBERG (124 Canada), V. RAMASWAMY (124 Canada) and M.D. TAYLOR (124 Canada)

Edition

Cancer Cell, Cambridge, Cell Press, 2017, 1535-6108

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 22.844

RIV identification code

RIV/00216224:14110/17:00098842

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ccell.2017.05.005

UT WoS

000403074800005

Keywords in English

Intertumoral Heterogeneity

Abstract

V originále

While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.

Links

EE2.3.20.0183, research and development project

Name: Centrum experimentální biomedicíny

Citovat

CAVALLI, F.M.G., M. REMKE, L. RAMPASEK, J. PEACOCK, D.J.H. SHIH, B. LUU, L. GARZIA, J. TORCHIA, C. NOR, A.S. MORRISSY, S. AGNIHOTRI, Y.Y. THOMPSON, C.M. KUZAN-FISCHER, H. FAROOQ, K. ISAEV, C. DANIELS, B.K. CHO, S.K. KIM, K.C. WANG, J.Y. LEE, W.A. GRAJKOWSKA, M. PEREK-POLNIK, A. VASILJEVIC, C. FAURE-CONTER, A. JOUVET, C. GIANNINI, A.A.N. RAO, K.K.W. LI, H.K. NG, C.G. EBERHART, I.F. POLLACK, R.L. HAMILTON, G.Y. GILLESPIE, J.M. OLSON, S. LEARY, W.A. WEISS, B. LACH, L.B. CHAMBLESS, R.C. THOMPSON, M.K. COOPER, R. VIBHAKAR, P. HAUSER, M.L.C. van VEELEN, J.M. KROS, P.J. FRENCH, Y.S. RA, T. KUMABE, E. LOPEZ-AGUILAR, Karel ZITTERBART, Jaroslav ŠTĚRBA, G. FINOCCHIARO, M. MASSIMINO, E.G. VAN MEIR, S. OSUKA, T. SHOFUDA, A. KLEKNER, M. ZOLLO, J.R. LEONARD, J.B. RUBIN, N. JABADO, S. ALBRECHT, J. MORA, T.E. VAN METER, S. JUNG, A.S. MOORE, A.R. HALLAHAN, J.A. CHAN, D.C. TIRAPELI, C.G. CARLOTTO, M. FOULADI, J. PIMENTEL, C.C. FARIA, A.G. SAAD, L. MASSIMI, L.M. LIAU, H. WHEELER, H. NAKAMURA, S.K. ELBABAA, M. PEREZPENA DIAZCONTI, F.C. PONCE DE LEÓN, S. ROBINSON, M. ZAPOTOCKY, A. LASSALETTA, A. HUANG, C.E. HAWKINS, U. TABORI, E. BOUFFET, U. BARTELS, P.B. DIRKS, J.T. RUTKA, G.D. BADER, J. REIMAND, A. GOLDENBERG, V. RAMASWAMY and M.D. TAYLOR. Intertumoral Heterogeneity within Medulloblastoma Subgroups. Cancer Cell. Cambridge: Cell Press, 2017, vol. 31, No 6, p. "737"-"+", 24 pp. ISSN 1535-6108. Available from: https://dx.doi.org/10.1016/j.ccell.2017.05.005.

@article{1399418,
   author = {Cavalli, F.M.G. and Remke, M. and Rampasek, L. and Peacock, J. and Shih, D.J.H. and Luu, B. and Garzia, L. and Torchia, J. and Nor, C. and Morrissy, A.S. and Agnihotri, S. and Thompson, Y.Y. and KuzanandFischer, C.M. and Farooq, H. and Isaev, K. and Daniels, C. and Cho, B.K. and Kim, S.K. and Wang, K.C. and Lee, J.Y. and Grajkowska, W.A. and PerekandPolnik, M. and Vasiljevic, A. and FaureandConter, C. and Jouvet, A. and Giannini, C. and Rao, A.A.N. and Li, K.K.W. and Ng, H.K. and Eberhart, C.G. and Pollack, I.F. and Hamilton, R.L. and Gillespie, G.Y. and Olson, J.M. and Leary, S. and Weiss, W.A. and Lach, B. and Chambless, L.B. and Thompson, R.C. and Cooper, M.K. and Vibhakar, R. and Hauser, P. and Veelen, M.L.C. van and Kros, J.M. and French, P.J. and Ra, Y.S. and Kumabe, T. and LopezandAguilar, E. and Zitterbart, Karel and Štěrba, Jaroslav and Finocchiaro, G. and Massimino, M. and Van Meir, E.G. and Osuka, S. and Shofuda, T. and Klekner, A. and Zollo, M. and Leonard, J.R. and Rubin, J.B. and Jabado, N. and Albrecht, S. and Mora, J. and Van Meter, T.E. and Jung, S. and Moore, A.S. and Hallahan, A.R. and Chan, J.A. and Tirapeli, D.C. and Carlotto, C.G. and Fouladi, M. and Pimentel, J. and Faria, C.C. and Saad, A.G. and Massimi, L. and Liau, L.M. and Wheeler, H. and Nakamura, H. and Elbabaa, S.K. and Perezpena Diazconti, M. and Ponce de León, F.C. and Robinson, S. and Zapotocky, M. and Lassaletta, A. and Huang, A. and Hawkins, C.E. and Tabori, U. and Bouffet, E. and Bartels, U. and Dirks, P.B. and Rutka, J.T. and Bader, G.D. and Reimand, J. and Goldenberg, A. and Ramaswamy, V. and Taylor, M.D.},
   article_location = {Cambridge},
   article_number = {6},
   doi = {http://dx.doi.org/10.1016/j.ccell.2017.05.005},
   keywords = {Intertumoral Heterogeneity},
   language = {eng},
   issn = {1535-6108},
   journal = {Cancer Cell},
   title = {Intertumoral Heterogeneity within Medulloblastoma Subgroups},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1399418
AU  - Cavalli, F.M.G. - Remke, M. - Rampasek, L. - Peacock, J. - Shih, D.J.H. - Luu, B. - Garzia, L. - Torchia, J. - Nor, C. - Morrissy, A.S. - Agnihotri, S. - Thompson, Y.Y. - Kuzan-Fischer, C.M. - Farooq, H. - Isaev, K. - Daniels, C. - Cho, B.K. - Kim, S.K. - Wang, K.C. - Lee, J.Y. - Grajkowska, W.A. - Perek-Polnik, M. - Vasiljevic, A. - Faure-Conter, C. - Jouvet, A. - Giannini, C. - Rao, A.A.N. - Li, K.K.W. - Ng, H.K. - Eberhart, C.G. - Pollack, I.F. - Hamilton, R.L. - Gillespie, G.Y. - Olson, J.M. - Leary, S. - Weiss, W.A. - Lach, B. - Chambless, L.B. - Thompson, R.C. - Cooper, M.K. - Vibhakar, R. - Hauser, P. - Veelen, M.L.C. van - Kros, J.M. - French, P.J. - Ra, Y.S. - Kumabe, T. - Lopez-Aguilar, E. - Zitterbart, Karel - Štěrba, Jaroslav - Finocchiaro, G. - Massimino, M. - Van Meir, E.G. - Osuka, S. - Shofuda, T. - Klekner, A. - Zollo, M. - Leonard, J.R. - Rubin, J.B. - Jabado, N. - Albrecht, S. - Mora, J. - Van Meter, T.E. - Jung, S. - Moore, A.S. - Hallahan, A.R. - Chan, J.A. - Tirapeli, D.C. - Carlotto, C.G. - Fouladi, M. - Pimentel, J. - Faria, C.C. - Saad, A.G. - Massimi, L. - Liau, L.M. - Wheeler, H. - Nakamura, H. - Elbabaa, S.K. - Perezpena Diazconti, M. - Ponce de León, F.C. - Robinson, S. - Zapotocky, M. - Lassaletta, A. - Huang, A. - Hawkins, C.E. - Tabori, U. - Bouffet, E. - Bartels, U. - Dirks, P.B. - Rutka, J.T. - Bader, G.D. - Reimand, J. - Goldenberg, A. - Ramaswamy, V. - Taylor, M.D.
PY  - 2017
TI  - Intertumoral Heterogeneity within Medulloblastoma Subgroups
JF  - Cancer Cell
VL  - 31
IS  - 6
SP  - "737"-"+"
EP  - "737"-"+"
PB  - Cell Press
SN  - 15356108
KW  - Intertumoral Heterogeneity
N2  - While molecular subgrouping has revolutionized medulloblastoma classification, the extent of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to genome-wide DNA methylation and gene expression data across 763 primary samples identifies very homogeneous clusters of patients, supporting the presence of medulloblastoma subtypes. After integration of somatic copy-number alterations, and clinical features specific to each cluster, we identify 12 different subtypes of medulloblastoma. Integrative analysis using SNF further delineates group 3 from group 4 medulloblastoma, which is not as readily apparent through analyses of individual data types. Two clear subtypes of infants with Sonic Hedgehog medulloblastoma with disparate outcomes and biology are identified. Medulloblastoma subtypes identified through integrative clustering have important implications for stratification of future clinical trials.
ER  -

CAVALLI, F.M.G., M. REMKE, L. RAMPASEK, J. PEACOCK, D.J.H. SHIH, B. LUU, L. GARZIA, J. TORCHIA, C. NOR, A.S. MORRISSY, S. AGNIHOTRI, Y.Y. THOMPSON, C.M. KUZAN-FISCHER, H. FAROOQ, K. ISAEV, C. DANIELS, B.K. CHO, S.K. KIM, K.C. WANG, J.Y. LEE, W.A. GRAJKOWSKA, M. PEREK-POLNIK, A. VASILJEVIC, C. FAURE-CONTER, A. JOUVET, C. GIANNINI, A.A.N. RAO, K.K.W. LI, H.K. NG, C.G. EBERHART, I.F. POLLACK, R.L. HAMILTON, G.Y. GILLESPIE, J.M. OLSON, S. LEARY, W.A. WEISS, B. LACH, L.B. CHAMBLESS, R.C. THOMPSON, M.K. COOPER, R. VIBHAKAR, P. HAUSER, M.L.C. van VEELEN, J.M. KROS, P.J. FRENCH, Y.S. RA, T. KUMABE, E. LOPEZ-AGUILAR, Karel ZITTERBART, Jaroslav ŠTĚRBA, G. FINOCCHIARO, M. MASSIMINO, E.G. VAN MEIR, S. OSUKA, T. SHOFUDA, A. KLEKNER, M. ZOLLO, J.R. LEONARD, J.B. RUBIN, N. JABADO, S. ALBRECHT, J. MORA, T.E. VAN METER, S. JUNG, A.S. MOORE, A.R. HALLAHAN, J.A. CHAN, D.C. TIRAPELI, C.G. CARLOTTO, M. FOULADI, J. PIMENTEL, C.C. FARIA, A.G. SAAD, L. MASSIMI, L.M. LIAU, H. WHEELER, H. NAKAMURA, S.K. ELBABAA, M. PEREZPENA DIAZCONTI, F.C. PONCE DE LEÓN, S. ROBINSON, M. ZAPOTOCKY, A. LASSALETTA, A. HUANG, C.E. HAWKINS, U. TABORI, E. BOUFFET, U. BARTELS, P.B. DIRKS, J.T. RUTKA, G.D. BADER, J. REIMAND, A. GOLDENBERG, V. RAMASWAMY and M.D. TAYLOR. Intertumoral Heterogeneity within Medulloblastoma Subgroups. \textit{Cancer Cell}. Cambridge: Cell Press, 2017, vol.~31, No~6, p.~''737''-''+'', 24 pp. ISSN~1535-6108. Available from: https://dx.doi.org/10.1016/j.ccell.2017.05.005.

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