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@article{1401254, author = {Kralickova, P. and Kuhnova, J. and Soucek, O. and Vodarek, P. and Zak, P. and Simkovic, M. and Motyckova, M. and Smolej, L. and Mala, E. and Andrys, C. and Krejsek, J. and Thon, Vojtěch}, article_location = {London}, article_number = {7304658}, doi = {http://dx.doi.org/10.1155/2017/7304658}, keywords = {Pneumococcal Capsular Polysaccharides; Natural Anti-Galactosyl; Humoral Immunodeficiencies}, language = {eng}, issn = {2314-8861}, journal = {Journal of Immunology Research}, title = {Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies}, volume = {2017}, year = {2017} }
TY - JOUR ID - 1401254 AU - Kralickova, P. - Kuhnova, J. - Soucek, O. - Vodarek, P. - Zak, P. - Simkovic, M. - Motyckova, M. - Smolej, L. - Mala, E. - Andrys, C. - Krejsek, J. - Thon, Vojtěch PY - 2017 TI - Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies JF - Journal of Immunology Research VL - 2017 IS - 7304658 SP - 1-8 EP - 1-8 PB - Hindawi SN - 23148861 KW - Pneumococcal Capsular Polysaccharides KW - Natural Anti-Galactosyl KW - Humoral Immunodeficiencies N2 - Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients with common variable immunodeficiency (CVID), and (3) a healthy population and to explore their diagnostic and prognostic potential. Serum immunoglobulin levels and levels of anti-Gal IgG, IgA, and IgM and anti-PCP IgG and IgG2 were determined in 59 CLL patients, 30 CVID patients, and 67 healthy controls. Levels of IgG, IgA, IgM, anti-Gal IgA, anti-Gal IgM, and anti-PCP IgA were lower in CLL and CVID patients than in healthy controls. Decrease in the levels of IgA, IgM, anti-Gal IgA, and anti-PCP IgA was less pronounced in the CLL group than in the CVID group. IgA decline, anti-Gal IgA, anti-PCP IgA, and anti-PCP IgG2 were negatively correlated with CLL stage. We devise the evaluation of anti-Gal antibodies to be a routine test in humoral immunodeficiency diagnostics, even in cases of immunoglobulin substitution therapy. Significant reductions, mainly in anti-Gal IgA, IgM, and anti-PCP IgA levels, may have prognostic importance in CLL patients. ER -
KRALICKOVA, P., J. KUHNOVA, O. SOUCEK, P. VODAREK, P. ZAK, M. SIMKOVIC, M. MOTYCKOVA, L. SMOLEJ, E. MALA, C. ANDRYS, J. KREJSEK a Vojtěch THON. Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies. \textit{Journal of Immunology Research}. London: Hindawi, 2017, roč.~2017, č.~7304658, s.~1-8. ISSN~2314-8861. Dostupné z: https://dx.doi.org/10.1155/2017/7304658.
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