J 2017

Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation

BRABENEC, Luboš, Jiří MEKYSKA, Zoltán GALÁŽ a Irena REKTOROVÁ

Základní údaje

Originální název

Speech disorders in Parkinson's disease: early diagnostics and effects of medication and brain stimulation

Autoři

BRABENEC, Luboš (203 Česká republika, garant, domácí), Jiří MEKYSKA (203 Česká republika), Zoltán GALÁŽ (703 Slovensko) a Irena REKTOROVÁ (203 Česká republika, domácí)

Vydání

Journal of Neural Transmission, Wien, SPRINGER WIEN, 2017, 0300-9564

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30103 Neurosciences

Stát vydavatele

Rakousko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 2.779

Kód RIV

RIV/00216224:14110/17:00095693

Organizační jednotka

Lékařská fakulta

DOI

UT WoS

000394433100004

Klíčová slova anglicky

Hypokinetic dysarthria; Parkinson’s disease; Acoustic analysis; rTMS; DBS; Dopaminergic medication; Functional imaging

Štítky

Příznaky

Mezinárodní význam, Recenzováno
Změněno: 13. 3. 2018 19:43, Soňa Böhmová

Anotace

V originále

Hypokinetic dysarthria (HD) occurs in 90% of Parkinson’s disease (PD) patients. It manifests specifically in the areas of articulation, phonation, prosody, speech fluency, and faciokinesis. We aimed to systematically review papers on HD in PD with a special focus on (1) early PD diagnosis and monitoring of the disease progression using acoustic voice and speech analysis, and (2) functional imaging studies exploring neural correlates of HD in PD, and (3) clinical studies using acoustic analysis to evaluate effects of dopaminergic medication and brain stimulation. A systematic literature search of articles written in English before March 2016 was conducted in the Web of Science, PubMed, SpringerLink, and IEEE Xplore databases using and combining specific relevant keywords. Articles were categorized into three groups: (1) articles focused on neural correlates of HD in PD using functional imaging (n = 13); (2) articles dealing with the acoustic analysis of HD in PD (n = 52); and (3) articles concerning specifically dopaminergic and brain stimulation-related effects as assessed by acoustic analysis (n = 31); the groups were then reviewed. We identified 14 combinations of speech tasks and acoustic features that can be recommended for use in describing the main features of HD in PD. While only a few acoustic parameters correlate with limb motor symptoms and can be partially relieved by dopaminergic medication, HD in PD seems to be mainly related to non-dopaminergic deficits and associated particularly with non-motor symptoms. Future studies should combine non-invasive brain stimulation with voice behavior approaches to achieve the best treatment effects by enhancing auditory-motor integration.

Návaznosti

NV16-30805A, projekt VaV
Název: Efekt neinvazivní stimulace mozku na hypokinetickou dysartrii, mikrografii a mozkovou plasticitu u pacientů s Parkinsonovou nemocí