| MONTAIGU, A., A. OELJEKLAUS, J. KRAHN, J.H. SULIMAN, M.N.S. HALDER, V. de ANSORENA, E. NICKEL, S. SCHLICHT, M. PLIHAL, O. KUBIASOVA, Lenka RADOVÁ, L. KRACHER, B. TOTH, R. KASCHANI, F. COUPLAND, G. KOMBRINK a E. KAISER. The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock. ACS CHEMICAL BIOLOGY. Washington D.C.: AMER CHEMICAL SOC, 2017, roč. 12, č. 6, s. 1466-1471. ISSN 1554-8929. Dostupné z: https://dx.doi.org/10.1021/acschembio.6b00978. |
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@article{1403113,
author = {Montaigu, A. and Oeljeklaus, A. and Krahn, J. and Suliman, J.H. and Halder, M.N.S. and Ansorena, V. de and Nickel, E. and Schlicht, S. and Plihal, M. and Kubiasova, O. and Radová, Lenka and Kracher, L. and Toth, B. and Kaschani, R. and Coupland, F. and Kombrink, G. and Kaiser, E.},
article_location = {Washington D.C.},
article_number = {6},
doi = {http://dx.doi.org/10.1021/acschembio.6b00978},
keywords = {ARABIDOPSIS-THALIANA; CHEMICAL BIOLOGY; GENES; EXPRESSION; OPPORTUNITIES; SYSTEM; AUXIN; TIME},
language = {eng},
issn = {1554-8929},
journal = {ACS CHEMICAL BIOLOGY},
title = {The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock},
url = {http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00978},
volume = {12},
year = {2017}
}
TY - JOUR
ID - 1403113
AU - Montaigu, A. - Oeljeklaus, A. - Krahn, J. - Suliman, J.H. - Halder, M.N.S. - Ansorena, V. de - Nickel, E. - Schlicht, S. - Plihal, M. - Kubiasova, O. - Radová, Lenka - Kracher, L. - Toth, B. - Kaschani, R. - Coupland, F. - Kombrink, G. - Kaiser, E.
PY - 2017
TI - The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
JF - ACS CHEMICAL BIOLOGY
VL - 12
IS - 6
SP - 1466-1471
EP - 1466-1471
PB - AMER CHEMICAL SOC
SN - 15548929
KW - ARABIDOPSIS-THALIANA
KW - CHEMICAL BIOLOGY
KW - GENES
KW - EXPRESSION
KW - OPPORTUNITIES
KW - SYSTEM
KW - AUXIN
KW - TIME
UR - http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00978
L2 - http://pubs.acs.org/doi/abs/10.1021/acschembio.6b00978
N2 - Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules.
ER -
MONTAIGU, A., A. OELJEKLAUS, J. KRAHN, J.H. SULIMAN, M.N.S. HALDER, V. de ANSORENA, E. NICKEL, S. SCHLICHT, M. PLIHAL, O. KUBIASOVA, Lenka RADOVÁ, L. KRACHER, B. TOTH, R. KASCHANI, F. COUPLAND, G. KOMBRINK a E. KAISER. The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock. \textit{ACS CHEMICAL BIOLOGY}. Washington D.C.: AMER CHEMICAL SOC, 2017, roč.~12, č.~6, s.~1466-1471. ISSN~1554-8929. Dostupné z: https://dx.doi.org/10.1021/acschembio.6b00978.
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