Non-Invasive Assessment of Vascular System Function and Damage
Induced by Anthracycline Treatment in the Pediatric Cancer
Survivors

J 2017

Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors

BUDINSKAYA, Ksenia, Veronika PUCHNEROVÁ, Jana SVAČINOVÁ, Jan NOVÁK, Hana HRSTKOVÁ et. al.

Základní údaje

Originální název

Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors

Autoři

BUDINSKAYA, Ksenia (643 Rusko, domácí), Veronika PUCHNEROVÁ (203 Česká republika, domácí), Jana SVAČINOVÁ (203 Česká republika, garant, domácí), Jan NOVÁK (203 Česká republika, domácí), Hana HRSTKOVÁ (203 Česká republika, domácí), Marie NOVÁKOVÁ (203 Česká republika, domácí), Anna PEKAŘOVÁ (203 Česká republika, domácí), Matej PEKAŘ (703 Slovensko, domácí) a Zuzana NOVÁKOVÁ (203 Česká republika, domácí)

Vydání

Physiological Research, Praha, Fyziologický ústav AV ČR, 2017, 0862-8408

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30105 Physiology

Stát vydavatele

Česká republika

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 1.324

Kód RIV

RIV/00216224:14110/17:00099503

Organizační jednotka

Lékařská fakulta

UT WoS

000422901400014

Klíčová slova anglicky

Anthracyclines; Cardiotoxicity; Pulse wave velocity; Pulse wave analysis; Arterial stiffness

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 17:02, Soňa Böhmová

Anotace

V originále

Anthracyclines represent one of the important classes of anti-cancer drugs; however, their major disadvantage is their profound cardiovascular toxicity. This study aimed to evaluate influence of anthracyclines on cardiovascular stiffness parameters estimated from pulse wave (PW). PW was measured in 59 cancer survivors treated with anthracyclines in childhood and in 248 healthy age-matched controls. Both patients and controls were divided into three age groups (13 – 15, 16 – 18 and 19 – 24 years). Central PW augmentation index (C-AI75) and augmentation pressure (C-AP75), both normalized to heart rate 75 bpm, were calculated as parameters of arterial wall stiffness. Central Buckberg sub-endocardial viability ratio (SEVR) was calculated as a parameter of diastolic function. Patients and controls were compared in each age group. C-AI75 and C-AP75 were significantly increased in patients in age groups 16 – 18 and 19 – 24 years. SEVR was decreased in patients in the oldest age group. Our results suggest that although toxic influence of anthracyclines to arterial wall and heart are developing during childhood and puberty, they can be detected rather in the adulthood. These changes are yet subclinical; however, their presence ndicates potentially increased cardiovascular risk in childhood cancer survivors treated with anthracyclines during childhood.

Návaznosti

MUNI/A/1355/2016, interní kód MU

Název: Kardiovaskulární systém očima molekulární fyziologie

Investor: Masarykova univerzita, Kardiovaskulární systém očima molekulární fyziologie, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

BUDINSKAYA, Ksenia, Veronika PUCHNEROVÁ, Jana SVAČINOVÁ, Jan NOVÁK, Hana HRSTKOVÁ, Marie NOVÁKOVÁ, Anna PEKAŘOVÁ, Matej PEKAŘ a Zuzana NOVÁKOVÁ. Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors. Physiological Research. Praha: Fyziologický ústav AV ČR, 2017, roč. 66, Suppl. 4, s. "S553"-"S560", 8 s. ISSN 0862-8408.

@article{1404202,
   author = {Budinskaya, Ksenia and Puchnerová, Veronika and Svačinová, Jana and Novák, Jan and Hrstková, Hana and Nováková, Marie and Pekařová, Anna and Pekař, Matej and Nováková, Zuzana},
   article_location = {Praha},
   article_number = {Suppl. 4},
   keywords = {Anthracyclines; Cardiotoxicity; Pulse wave velocity; Pulse wave analysis; Arterial stiffness},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors},
   volume = {66},
   year = {2017}
}

TY  - JOUR
ID  - 1404202
AU  - Budinskaya, Ksenia - Puchnerová, Veronika - Svačinová, Jana - Novák, Jan - Hrstková, Hana - Nováková, Marie - Pekařová, Anna - Pekař, Matej - Nováková, Zuzana
PY  - 2017
TI  - Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors
JF  - Physiological Research
VL  - 66
IS  - Suppl. 4
SP  - "S553"-"S560"
EP  - "S553"-"S560"
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - Anthracyclines
KW  - Cardiotoxicity
KW  - Pulse wave velocity
KW  - Pulse wave analysis
KW  - Arterial stiffness
N2  - Anthracyclines represent one of the important classes of anti-cancer drugs; however, their major disadvantage is their profound cardiovascular toxicity. This study aimed to evaluate influence of anthracyclines on cardiovascular stiffness parameters estimated from pulse wave (PW). PW was measured in 59 cancer survivors treated with anthracyclines in childhood and in 248 healthy age-matched controls. Both patients and controls were divided into three age groups (13 – 15, 16 – 18 and 19 – 24 years). Central PW augmentation index (C-AI75) and augmentation pressure (C-AP75), both normalized to heart rate 75 bpm, were calculated as parameters of arterial wall stiffness. Central Buckberg sub-endocardial viability ratio (SEVR) was calculated as a parameter of diastolic function. Patients and controls were compared in each age group. C-AI75 and C-AP75 were significantly increased in patients in age groups 16 – 18 and 19 – 24 years. SEVR was decreased in patients in the oldest age group. Our results suggest that although toxic influence of anthracyclines to arterial wall and heart are developing during childhood and puberty, they can be detected rather in the adulthood. These changes are yet subclinical; however, their presence ndicates potentially increased cardiovascular risk in childhood cancer survivors treated with anthracyclines during childhood.
ER  -

BUDINSKAYA, Ksenia, Veronika PUCHNEROVÁ, Jana SVAČINOVÁ, Jan NOVÁK, Hana HRSTKOVÁ, Marie NOVÁKOVÁ, Anna PEKAŘOVÁ, Matej PEKAŘ a Zuzana NOVÁKOVÁ. Non-Invasive Assessment of Vascular System Function and Damage Induced by Anthracycline Treatment in the Pediatric Cancer Survivors. \textit{Physiological Research}. Praha: Fyziologický ústav AV ČR, 2017, roč.~66, Suppl. 4, s.~''S553''-''S560'', 8 s. ISSN~0862-8408.

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