Genetic predisposition for chronic venous insufficiency in
several genes for matrix metalloproteinases (MMP-2, MMP-9,
MMP-12) and their inhibitor TIMP-2

J 2017

Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2

SLONKOVÁ, Veronika, Veronika Jr. SLONKOVÁ, Anna VAŠKŮ a Vladimír VAŠKŮ

Základní údaje

Originální název

Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2

Autoři

SLONKOVÁ, Veronika (203 Česká republika, garant, domácí), Veronika Jr. SLONKOVÁ (203 Česká republika), Anna VAŠKŮ (203 Česká republika, domácí) a Vladimír VAŠKŮ (203 Česká republika, domácí)

Vydání

Journal of the European Academy of Dermatovenereology, Hoboken, Wiley-Blackwell, 2017, 0926-9959

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30216 Dermatology and venereal diseases

Stát vydavatele

Velká Británie a Severní Irsko

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 4.287

Kód RIV

RIV/00216224:14110/17:00099676

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1111/jdv.14447

UT WoS

000413582400055

Klíčová slova česky

venózní insuficience, MMP; TIMP

Klíčová slova anglicky

Venous insufficiency; MMP; TIMP

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 20. 3. 2018 15:25, Soňa Böhmová

Anotace

V originále

OBJECTIVE: The project was scheduled as a case-control study to investigate the correlation between MMP-2 (rs243864), MMP-9 (3918242), MMP-12 (rs7123600) and TIMP-2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The genotype and phenotype research envisages the testing of possible associations between MMP and TIMP-2 genotypes and phenotypes of CVD. MATERIAL AND METHODS: 150 patients with CVD and 227 controls were enrolled into the study. The MMPs and TIMP-2 genotypes were identified by the PCR method and restriction analysis according to standard protocols. RESULTS: The G allele of MMP-2 -790 T/G was 1.85 times more frequent in men with CVD than in the control group (P = 0.008). The T allele of MMP-9 -1562 C/T was observed 2.571 times more frequently in patients with CVD than in the control individuals (both in men and women) with clinically significant specificity (P = 0.0000009). The G allele of MMP-12 rs7123600 was determined 2.082 times more frequently in female patients with CVD than in the control group with clinically significant specificity (P = 0.02). No significant result in TIMP-2 rs8176329 polymorphism in the case-control study was observed. CVD women with G allele in MMP-2 -790 T/G in the genotype-phenotype study are seen to develop ulceration 2.539 times more frequently (P = 0.003). The G allele of MMP-12 rs7123600 was detected 3.167 times more frequently in CVD women with ulceration compared with CVD women without ulceration (P = 0.007). In CVD men in C6 stage, the incidence of AG genotype in rs7123600 MMP-12 polymorphism was found to be 4.675 times higher compared to CVD women with C6 staging (P = 0.005). The AG genotype in TIMP 2 rs8176329 polymorphism was found to be associated with higher risk of tumour (P = 0.01). CONCLUSION: Studying these polymorphisms can contribute to better identification of patients at higher risk of developing CVD, while providing the most appropriate prevention and treatment strategies.

Návaznosti

MUNI/A/1401/2016, interní kód MU

Název: Patofyziologické biomarkery u komplexních nemocí (Akronym: Biomarkery)

Investor: Masarykova univerzita, Patofyziologické biomarkery u komplexních nemocí, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

MUNI/A/1420/2016, interní kód MU

Název: Hodnocení diagnostických a terapeutických metod u pacientů s vybranými kožními nemocemi (Akronym: Genetika, světloléčba)

Investor: Masarykova univerzita, Hodnocení diagnostických a terapeutických metod u pacientů s vybranými kožními nemocemi, DO R. 2020_Kategorie A - Specifický výzkum - Studentské výzkumné projekty

Citovat

SLONKOVÁ, Veronika, Veronika Jr. SLONKOVÁ, Anna VAŠKŮ a Vladimír VAŠKŮ. Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. Journal of the European Academy of Dermatovenereology. Hoboken: Wiley-Blackwell, 2017, roč. 31, č. 10, s. 1746-1752. ISSN 0926-9959. Dostupné z: https://dx.doi.org/10.1111/jdv.14447.

@article{1405510,
   author = {Slonková, Veronika and Slonková, Veronika Jr. and Vašků, Anna and Vašků, Vladimír},
   article_location = {Hoboken},
   article_number = {10},
   doi = {http://dx.doi.org/10.1111/jdv.14447},
   keywords = {Venous insufficiency; MMP; TIMP},
   language = {eng},
   issn = {0926-9959},
   journal = {Journal of the European Academy of Dermatovenereology},
   title = {Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2},
   volume = {31},
   year = {2017}
}

TY  - JOUR
ID  - 1405510
AU  - Slonková, Veronika - Slonková, Veronika Jr. - Vašků, Anna - Vašků, Vladimír
PY  - 2017
TI  - Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2
JF  - Journal of the European Academy of Dermatovenereology
VL  - 31
IS  - 10
SP  - 1746-1752
EP  - 1746-1752
PB  - Wiley-Blackwell
SN  - 09269959
KW  - Venous insufficiency
KW  - MMP
KW  - TIMP
N2  - OBJECTIVE: The project was scheduled as a case-control study to investigate the correlation between MMP-2 (rs243864), MMP-9 (3918242), MMP-12 (rs7123600) and TIMP-2 (rs8176329) polymorphisms and chronic venous disease (CVD) risk. The genotype and phenotype research envisages the testing of possible associations between MMP and TIMP-2 genotypes and phenotypes of CVD. MATERIAL AND METHODS: 150 patients with CVD and 227 controls were enrolled into the study. The MMPs and TIMP-2 genotypes were identified by the PCR method and restriction analysis according to standard protocols. RESULTS: The G allele of MMP-2 -790 T/G was 1.85 times more frequent in men with CVD than in the control group (P = 0.008). The T allele of MMP-9 -1562 C/T was observed 2.571 times more frequently in patients with CVD than in the control individuals (both in men and women) with clinically significant specificity (P = 0.0000009). The G allele of MMP-12 rs7123600 was determined 2.082 times more frequently in female patients with CVD than in the control group with clinically significant specificity (P = 0.02). No significant result in TIMP-2 rs8176329 polymorphism in the case-control study was observed. CVD women with G allele in MMP-2 -790 T/G in the genotype-phenotype study are seen to develop ulceration 2.539 times more frequently (P = 0.003). The G allele of MMP-12 rs7123600 was detected 3.167 times more frequently in CVD women with ulceration compared with CVD women without ulceration (P = 0.007). In CVD men in C6 stage, the incidence of AG genotype in rs7123600 MMP-12 polymorphism was found to be 4.675 times higher compared to CVD women with C6 staging (P = 0.005). The AG genotype in TIMP 2 rs8176329 polymorphism was found to be associated with higher risk of tumour (P = 0.01). CONCLUSION: Studying these polymorphisms can contribute to better identification of patients at higher risk of developing CVD, while providing the most appropriate prevention and treatment strategies.
ER  -

SLONKOVÁ, Veronika, Veronika Jr. SLONKOVÁ, Anna VAŠKŮ a Vladimír VAŠKŮ. Genetic predisposition for chronic venous insufficiency in several genes for matrix metalloproteinases (MMP-2, MMP-9, MMP-12) and their inhibitor TIMP-2. \textit{Journal of the European Academy of Dermatovenereology}. Hoboken: Wiley-Blackwell, 2017, roč.~31, č.~10, s.~1746-1752. ISSN~0926-9959. Dostupné z: https://dx.doi.org/10.1111/jdv.14447.

Podrobný výpis o publikaci