BMP Signaling Regulates the Fate of Chondro-osteoprogenitor
Cells in Facial Mesenchyme in a Stage-Specific Manner

J 2016

BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner

CELÁ, Petra, marcela BUCHTOVÁ, Iva VESELÁ, Cathy FU, Jean-Philippe BOGARDI et. al.

Základní údaje

Originální název

BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner

Autoři

CELÁ, Petra (203 Česká republika, domácí), marcela BUCHTOVÁ (203 Česká republika, garant, domácí), Iva VESELÁ (203 Česká republika), Cathy FU (124 Kanada), Jean-Philippe BOGARDI (124 Kanada), Yiping SONG (124 Kanada), Amanda BARLOW (124 Kanada), Paul BUXTON (124 Kanada), Jiřina MEDALOVÁ (203 Česká republika), Philippa FRANCIS-WEST (124 Kanada) a Joy M. RICHMAN (124 Kanada)

Vydání

DEVELOPMENTAL DYNAMICS, Hoboken, NJ USA, WILEY-BLACKWELL, 2016, 1058-8388

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10605 Developmental biology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.004

Kód RIV

RIV/00216224:14310/16:00099784

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/DVDY.24422

UT WoS

000384752100005

Klíčová slova anglicky

BMP; chick embryo; Chondro-osteoprogenitor Cells ; facial development

Štítky

NZ, rivok

Změněno: 13. 4. 2018 12:49, Ing. Nicole Zrilić

Anotace

V originále

Lineage tracing has shown that most of the facial skeleton is derived from cranial neural crest cells. However, the local signals that influence postmigratory, neural crest-derived mesenchyme also play a major role in patterning the skeleton. Here, we study the role of BMP signaling in regulating the fate of chondro-osteoprogenitor cells in the face. A single Noggin-soaked bead inserted into stage 15 chicken embryos induced an ectopic cartilage resembling the interorbital septum within the palate and other midline structures. In contrast, the same treatment in stage 20 embryos caused a loss of bones. The molecular basis for the stage-specific response to Noggin lay in the simultaneous up-regulation of SOX9 and downregulation of RUNX2 in the maxillary mesenchyme, increased cell adhesiveness as shown by N-cadherin induction around the beads and increased RA pathway gene expression. None of these changes were observed in stage 20 embryos.These experiments demonstrate how slight changes in expression of growth factors such as BMPs could lead to gain or loss of cartilage in the upper jaw during vertebrate evolution. In addition, BMPs have at least two roles: one in patterning the skull and another in regulating the skeletogenic fates of neural crest-derived mesenchyme.

Citovat

CELÁ, Petra, marcela BUCHTOVÁ, Iva VESELÁ, Cathy FU, Jean-Philippe BOGARDI, Yiping SONG, Amanda BARLOW, Paul BUXTON, Jiřina MEDALOVÁ, Philippa FRANCIS-WEST a Joy M. RICHMAN. BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner. DEVELOPMENTAL DYNAMICS. Hoboken, NJ USA: WILEY-BLACKWELL, 2016, roč. 245, č. 9, s. 947-962. ISSN 1058-8388. Dostupné z: https://dx.doi.org/10.1002/DVDY.24422.

@article{1405989,
   author = {Celá, Petra and Buchtová, marcela and Veselá, Iva and Fu, Cathy and Bogardi, JeanandPhilippe and Song, Yiping and Barlow, Amanda and Buxton, Paul and Medalová, Jiřina and FrancisandWest, Philippa and Richman, Joy M.},
   article_location = {Hoboken, NJ USA},
   article_number = {9},
   doi = {http://dx.doi.org/10.1002/DVDY.24422},
   keywords = {BMP; chick embryo; Chondro-osteoprogenitor Cells ; facial development},
   language = {eng},
   issn = {1058-8388},
   journal = {DEVELOPMENTAL DYNAMICS},
   title = {BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/pdf},
   volume = {245},
   year = {2016}
}

TY  - JOUR
ID  - 1405989
AU  - Celá, Petra - Buchtová, marcela - Veselá, Iva - Fu, Cathy - Bogardi, Jean-Philippe - Song, Yiping - Barlow, Amanda - Buxton, Paul - Medalová, Jiřina - Francis-West, Philippa - Richman, Joy M.
PY  - 2016
TI  - BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner
JF  - DEVELOPMENTAL DYNAMICS
VL  - 245
IS  - 9
SP  - 947-962
EP  - 947-962
PB  - WILEY-BLACKWELL
SN  - 10588388
KW  - BMP
KW  - chick embryo
KW  - Chondro-osteoprogenitor Cells
KW  - facial development
UR  - http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/pdf
L2  - http://onlinelibrary.wiley.com/doi/10.1002/dvdy.24422/pdf
N2  - Lineage tracing has shown that most of the facial skeleton is derived from cranial neural crest cells. However, the local signals that influence postmigratory, neural crest-derived mesenchyme also play a major role in patterning the skeleton. Here, we study the role of BMP signaling in regulating the fate of chondro-osteoprogenitor cells in the face. A single Noggin-soaked bead inserted into stage 15 chicken embryos induced an ectopic cartilage resembling the interorbital septum within the palate and other midline structures. In contrast, the same treatment in stage 20 embryos caused a loss of bones. The molecular basis for the stage-specific response to Noggin lay in the simultaneous up-regulation of SOX9 and downregulation of RUNX2 in the maxillary mesenchyme, increased cell adhesiveness as shown by N-cadherin induction around the beads and increased RA pathway gene expression. None of these changes were observed in stage 20 embryos.These experiments demonstrate how slight changes in expression of growth factors such as BMPs could lead to gain or loss of cartilage in the upper jaw during vertebrate evolution. In addition, BMPs have at least two roles: one in patterning the skull and another in regulating the skeletogenic fates of neural crest-derived mesenchyme.
ER  -

CELÁ, Petra, marcela BUCHTOVÁ, Iva VESELÁ, Cathy FU, Jean-Philippe BOGARDI, Yiping SONG, Amanda BARLOW, Paul BUXTON, Jiřina MEDALOVÁ, Philippa FRANCIS-WEST a Joy M. RICHMAN. BMP Signaling Regulates the Fate of Chondro-osteoprogenitor Cells in Facial Mesenchyme in a Stage-Specific Manner. \textit{DEVELOPMENTAL DYNAMICS}. Hoboken, NJ USA: WILEY-BLACKWELL, 2016, roč.~245, č.~9, s.~947-962. ISSN~1058-8388. Dostupné z: https://dx.doi.org/10.1002/DVDY.24422.

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