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@article{1406114, author = {Janovská, Pavlína and Bryja, Vítězslav}, article_location = {Hoboken}, article_number = {24}, doi = {http://dx.doi.org/10.1111/bph.13949}, keywords = {LONG NONCODING RNA; WNT/BETA-CATENIN PATHWAY; EPITHELIAL-MESENCHYMAL TRANSITION; OVARIAN-CANCER CELLS; MOUSE SPERMATOGONIAL CELLS; REGULATE GENE-EXPRESSION; PROSTATE-SPECIFIC GENE; STEM-LIKE CELLS; BREAST-CANCER; CERVICAL-CANCER}, language = {eng}, issn = {0007-1188}, journal = {BRITISH JOURNAL OF PHARMACOLOGY}, title = {WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas}, volume = {174}, year = {2017} }
TY - JOUR ID - 1406114 AU - Janovská, Pavlína - Bryja, Vítězslav PY - 2017 TI - WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas JF - BRITISH JOURNAL OF PHARMACOLOGY VL - 174 IS - 24 SP - 4701-4715 EP - 4701-4715 PB - WILEY SN - 00071188 KW - LONG NONCODING RNA KW - WNT/BETA-CATENIN PATHWAY KW - EPITHELIAL-MESENCHYMAL TRANSITION KW - OVARIAN-CANCER CELLS KW - MOUSE SPERMATOGONIAL CELLS KW - REGULATE GENE-EXPRESSION KW - PROSTATE-SPECIFIC GENE KW - STEM-LIKE CELLS KW - BREAST-CANCER KW - CERVICAL-CANCER N2 - In this review, we discuss the intricate roles of the Wnt signalling network in the development and progression of mature B-cell-derived haematological malignancies, with a focus on chronic lymphocytic leukaemia (CLL) and related B-cell lymphomas. We review the current literature and highlight the differences between the beta-catenin-dependent and -independent branches of Wnt signalling. Special attention is paid to the role of the non-canonical Wnt/planar cell polarity (PCP) pathway, mediated by the Wnt-5-receptor tyrosine kinase-like orphan receptor (ROR1)-Dishevelled signalling axis in CLL. This is mainly because the Wnt/PCP co-receptor ROR1 was found to be overexpressed in CLL and the Wnt/PCP pathway contributes to numerous aspects of CLL pathogenesis. We also discuss the possibilities of therapeutically targeting the Wnt signalling pathways as an approach to disrupt the crucial interaction between malignant cells and their micro-environment. We also advocate the need for research in this direction for other lymphomas, namely, diffuse large B-cell lymphoma, Hodgkin lymphoma, mantle cell lymphoma, Burkitt lymphoma and follicular lymphoma where the Wnt signalling pathway probably plays a similar role. ER -
JANOVSKÁ, Pavlína a Vítězslav BRYJA. WNT signaling pathways in chronic lymphocytic leukemia and B cell lymphomas. \textit{BRITISH JOURNAL OF PHARMACOLOGY}. Hoboken: WILEY, 2017, roč.~174, č.~24, s.~4701-4715. ISSN~0007-1188. Dostupné z: https://dx.doi.org/10.1111/bph.13949.
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