Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders

ARAB, Anas, Anna WOJNA PELCZAR, Amit Suresh KHAIRNAR, Nikoletta SZABÓ and Jana RUDÁ. Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders. Brain Research Bulletin. Oxford: Pergamon-Elsevier Science LTD, 2018, vol. 139, MAY 2018, p. 91-98. ISSN 0361-9230. Available from: https://dx.doi.org/10.1016/j.brainresbull.2018.01.015.

Basic information

• Original name: Principles of Diffusion Kurtosis Imaging and its Role in Early Diagnosis of Neurodegenerative Disorders
• Name in Czech: Princip Diffusion Kurtosis Imaging a jeho role v časné diagnostice neurodegenerativních onemocnění
• Authors: ARAB, Anas (760 Syrian Arab Republic, belonging to the institution), Anna WOJNA PELCZAR (616 Poland, belonging to the institution), Amit Suresh KHAIRNAR (356 India, guarantor), Nikoletta SZABÓ (348 Hungary, belonging to the institution) and Jana RUDÁ (203 Czech Republic, belonging to the institution).
• Edition: Brain Research Bulletin, Oxford, Pergamon-Elsevier Science LTD, 2018, 0361-9230.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30103 Neurosciences
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 3.103
• RIV identification code: RIV/00216224:14110/18:00102274
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.brainresbull.2018.01.015
• UT WoS: 000433651600011
• Keywords in English: Diffusion kurtosis imaging; neuroimaging; neurodegenerative disorders; Parkinson’s disease; Alzheimer’s disease; Huntington’s disease
• Tags: 14110516, podil, rivok
• Tags: International impact, Reviewed

Abstract

Pathology of neurodegenerative diseases can be correlated with intra-neuronal as well as extracellular changes which lead to neuronal degeneration. The central nervous system (CNS) is a complex structure comprising of many biological barriers. These microstructural barriers might be affected by a variety of pathological processes. Specifically, changes in the brain tissue’s microstructure affect the diffusion of water which can be assessed non-invasively by diffusion weighted (DW) magnetic resonance imaging (MRI) techniques. Hence, the purpose of this article is to summarize the ongoing clinical and preclinical research on Parkinson’s, Alzheimer’s and Huntington diseases, using DKI and to discuss the role of this technique as an early stage biomarker of neurodegenerative conditions.

Links

• MUNI/A/1132/2017, interní kód MU: Name: Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv

Investor: Masaryk University, Category A