Inducible nitric oxide synthase: Good or bad?

J 2017

Inducible nitric oxide synthase: Good or bad?

LIND, M., A. HAYES, M. CAPRNDA, D. PETROVIC, L. RODRIGO et. al.

Základní údaje

Originální název

Inducible nitric oxide synthase: Good or bad?

Autoři

LIND, M. (36 Austrálie), A. HAYES (36 Austrálie), M. CAPRNDA (703 Slovensko), D. PETROVIC (705 Slovinsko), L. RODRIGO (724 Španělsko), Peter KRUŽLIAK (703 Slovensko, garant, domácí) a A. ZULLI (36 Austrálie)

Vydání

BIOMEDICINE & PHARMACOTHERAPY, PARIS, ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017, 0753-3322

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30104 Pharmacology and pharmacy

Stát vydavatele

Francie

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 3.457

Kód RIV

RIV/00216224:14110/17:00099908

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1016/j.biopha.2017.06.036

UT WoS

000407923000040

Klíčová slova anglicky

Nitric oxide synthase (NOS); Inducible NOS (iNOS); Endothelial NOS (eNOS); Cyclooxygenase-2 (COX-2); COX-2; Oxidative stress; Cardiovascular diseases

Štítky

EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 7. 2. 2018 15:08, Soňa Böhmová

Anotace

V originále

Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss its potentially beneficial roles. Additionally, we describe other molecules associated with iNOS in diseases such as atherosclerosis, and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD). (C) 2017 Elsevier Masson SAS. All rights reserved.

Citovat

LIND, M., A. HAYES, M. CAPRNDA, D. PETROVIC, L. RODRIGO, Peter KRUŽLIAK a A. ZULLI. Inducible nitric oxide synthase: Good or bad? BIOMEDICINE & PHARMACOTHERAPY. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017, roč. 93, SEP 2017, s. 370-375. ISSN 0753-3322. Dostupné z: https://dx.doi.org/10.1016/j.biopha.2017.06.036.

@article{1406937,
   author = {Lind, M. and Hayes, A. and Caprnda, M. and Petrovic, D. and Rodrigo, L. and Kružliak, Peter and Zulli, A.},
   article_location = {PARIS},
   article_number = {SEP 2017},
   doi = {http://dx.doi.org/10.1016/j.biopha.2017.06.036},
   keywords = {Nitric oxide synthase (NOS); Inducible NOS (iNOS); Endothelial NOS (eNOS); Cyclooxygenase-2 (COX-2); COX-2; Oxidative stress; Cardiovascular diseases},
   language = {eng},
   issn = {0753-3322},
   journal = {BIOMEDICINE & PHARMACOTHERAPY},
   title = {Inducible nitric oxide synthase: Good or bad?},
   volume = {93},
   year = {2017}
}

TY  - JOUR
ID  - 1406937
AU  - Lind, M. - Hayes, A. - Caprnda, M. - Petrovic, D. - Rodrigo, L. - Kružliak, Peter - Zulli, A.
PY  - 2017
TI  - Inducible nitric oxide synthase: Good or bad?
JF  - BIOMEDICINE & PHARMACOTHERAPY
VL  - 93
IS  - SEP 2017
SP  - 370-375
EP  - 370-375
PB  - ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
SN  - 07533322
KW  - Nitric oxide synthase (NOS)
KW  - Inducible NOS (iNOS)
KW  - Endothelial NOS (eNOS)
KW  - Cyclooxygenase-2 (COX-2)
KW  - COX-2
KW  - Oxidative stress
KW  - Cardiovascular diseases
N2  - Nitric oxide synthases (NOS) are a family of isoforms responsible for the synthesis of the potent dilator nitric oxide (NO). Expression of inducible NOS (iNOS) occurs in conditions of inflammation, and produces large amounts of NO. In pathological conditions iNOS is regarded as a harmful enzyme and is proposed to be a major contributor to diseases of the cardiovascular system such as atherosclerosis. In this review, we address the notion that iNOS is a detrimental enzyme in disease and discuss its potentially beneficial roles. Additionally, we describe other molecules associated with iNOS in diseases such as atherosclerosis, and current research on therapeutic inhibitors tested to reduced pathology associated with cardiovascular diseases (CVD). (C) 2017 Elsevier Masson SAS. All rights reserved.
ER  -

LIND, M., A. HAYES, M. CAPRNDA, D. PETROVIC, L. RODRIGO, Peter KRUŽLIAK a A. ZULLI. Inducible nitric oxide synthase: Good or bad? \textit{BIOMEDICINE \&{}amp; PHARMACOTHERAPY}. PARIS: ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2017, roč.~93, SEP 2017, s.~370-375. ISSN~0753-3322. Dostupné z: https://dx.doi.org/10.1016/j.biopha.2017.06.036.

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