The Role of Gene for Insulin Degrading Enzyme in the
Pathogenesis of Schizophrenia

a 2017

The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia

EWERLINGOVÁ, Laura, Jana JANOUTOVÁ, Jan LOCHMAN, Vladimír JANOUT, Ladislav HOSÁK et. al.

Basic information

Original name

The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia

Authors

EWERLINGOVÁ, Laura (703 Slovakia, belonging to the institution), Jana JANOUTOVÁ (203 Czech Republic), Jan LOCHMAN (203 Czech Republic, belonging to the institution), Vladimír JANOUT (203 Czech Republic), Ladislav HOSÁK (203 Czech Republic), Vladimír Josef BALCAR (36 Australia) and Omar ŠERÝ (203 Czech Republic, guarantor, belonging to the institution)

Edition

6th European Conference on Schizophrenia Research, 2017

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/17:00099919

Organization unit

Faculty of Science

Keywords in English

Insulin Degrading Enzyme;Schizophrenia

Abstract

V originále

Objectives The Insulin Degrading Enzyme (IDE) degrades intracellular insulin and other peptides. The IDE gene has been previously associated with type 2 diabetes mellitus1. The prevalence of diabetes is increased 2- to 3- fold in patients with schizophrenia2. Our objective was therefore to examine the association of IDE gene polymorphisms with the schizophrenia. Methods The association between IDE gene polymorphisms and schizophrenia has been studied in our case-control study involving 400 patients and 400 control subjects. The DNA was extracted from full blood samples and analyzed by the SNaPshot multiplex method on a genetic analyzer ABI PRISM 3100. Results In our study we have found statistically significant association between schizophrenia and one single nucleotide polymorphism (SNP) of the IDE gene. The AA genotype of rs2421943 polymorphism shows a protective role, it decreases the risk of schizophrenia 0,76-fold (p = 0,01) and A allele decreases the risk 0,87-fold (p = 0,007). Conclusions Our study shows, that the comorbidity between schizophrenia and diabetes mellitus might have common genetic roots and IDE gene could become new candidate gene for further research of genetic causes of schizophrenia.

Links

MUNI/A/1278/2016, interní kód MU

Name: Podpora biochemického výzkumu v roce 2017

Investor: Masaryk University, Category A

Citovat

EWERLINGOVÁ, Laura, Jana JANOUTOVÁ, Jan LOCHMAN, Vladimír JANOUT, Ladislav HOSÁK, Vladimír Josef BALCAR and Omar ŠERÝ. The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia. In 6th European Conference on Schizophrenia Research. 2017.

@proceedings{1407042,
   author = {Ewerlingová, Laura and Janoutová, Jana and Lochman, Jan and Janout, Vladimír and Hosák, Ladislav and Balcar, Vladimír Josef and Šerý, Omar},
   booktitle = {6th European Conference on Schizophrenia Research},
   keywords = {Insulin Degrading Enzyme;Schizophrenia},
   language = {eng},
   title = {The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia},
   year = {2017}
}

TY  - CONF
ID  - 1407042
AU  - Ewerlingová, Laura - Janoutová, Jana - Lochman, Jan - Janout, Vladimír - Hosák, Ladislav - Balcar, Vladimír Josef - Šerý, Omar
PY  - 2017
TI  - The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia
KW  - Insulin Degrading Enzyme;Schizophrenia
N2  - Objectives The Insulin Degrading Enzyme (IDE) degrades intracellular insulin and other peptides. The IDE gene has been previously associated with type 2 diabetes mellitus1. The prevalence of diabetes is increased 2- to 3- fold in patients with schizophrenia2. Our objective was therefore to examine the association of IDE gene polymorphisms with the schizophrenia. Methods The association between IDE gene polymorphisms and schizophrenia has been studied in our case-control study involving 400 patients and 400 control subjects. The DNA was extracted from full blood samples and analyzed by the SNaPshot multiplex method on a genetic analyzer ABI PRISM 3100. Results In our study we have found statistically significant association between schizophrenia and one single nucleotide polymorphism (SNP) of the IDE gene. The AA genotype of rs2421943 polymorphism shows a protective role, it decreases the risk of schizophrenia 0,76-fold (p = 0,01) and A allele decreases the risk 0,87-fold (p = 0,007). Conclusions Our study shows, that the comorbidity between schizophrenia and diabetes mellitus might have common genetic roots and IDE gene could become new candidate gene for further research of genetic causes of schizophrenia.
ER  -

EWERLINGOVÁ, Laura, Jana JANOUTOVÁ, Jan LOCHMAN, Vladimír JANOUT, Ladislav HOSÁK, Vladimír Josef BALCAR and Omar ŠERÝ. The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia. In \textit{6th European Conference on Schizophrenia Research}. 2017.

Detailed Information on Publication Record