The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia

EWERLINGOVÁ, Laura, Jana JANOUTOVÁ, Jan LOCHMAN, Vladimír JANOUT, Ladislav HOSÁK, Vladimír Josef BALCAR and Omar ŠERÝ. The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia. In 6th European Conference on Schizophrenia Research. 2017.

Basic information

• Original name: The Role of Gene for Insulin Degrading Enzyme in the Pathogenesis of Schizophrenia
• Authors: EWERLINGOVÁ, Laura (703 Slovakia, belonging to the institution), Jana JANOUTOVÁ (203 Czech Republic), Jan LOCHMAN (203 Czech Republic, belonging to the institution), Vladimír JANOUT (203 Czech Republic), Ladislav HOSÁK (203 Czech Republic), Vladimír Josef BALCAR (36 Australia) and Omar ŠERÝ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: 6th European Conference on Schizophrenia Research, 2017.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/17:00099919
• Organization unit: Faculty of Science
• Keywords in English: Insulin Degrading Enzyme;Schizophrenia
• Tags: International impact

Abstract

Objectives The Insulin Degrading Enzyme (IDE) degrades intracellular insulin and other peptides. The IDE gene has been previously associated with type 2 diabetes mellitus1. The prevalence of diabetes is increased 2- to 3- fold in patients with schizophrenia2. Our objective was therefore to examine the association of IDE gene polymorphisms with the schizophrenia. Methods The association between IDE gene polymorphisms and schizophrenia has been studied in our case-control study involving 400 patients and 400 control subjects. The DNA was extracted from full blood samples and analyzed by the SNaPshot multiplex method on a genetic analyzer ABI PRISM 3100. Results In our study we have found statistically significant association between schizophrenia and one single nucleotide polymorphism (SNP) of the IDE gene. The AA genotype of rs2421943 polymorphism shows a protective role, it decreases the risk of schizophrenia 0,76-fold (p = 0,01) and A allele decreases the risk 0,87-fold (p = 0,007). Conclusions Our study shows, that the comorbidity between schizophrenia and diabetes mellitus might have common genetic roots and IDE gene could become new candidate gene for further research of genetic causes of schizophrenia.

Links

• MUNI/A/1278/2016, interní kód MU: Name: Podpora biochemického výzkumu v roce 2017

Investor: Masaryk University, Category A