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@article{1408455,
author = {Zavřel, Tomáš and Červený, Jan and Knoop, Henning and Steuer, Ralf},
article_location = {PHILADELPHIA},
article_number = {6},
doi = {http://dx.doi.org/10.1080/21655979.2016.1207017},
keywords = {biofuels; biotechnology; cyanobacteria; ethylene; genome-scale models (GSM); MIMS; photobioreactors; systems biology},
language = {eng},
issn = {2165-5979},
journal = {BIOENGINEERED},
title = {Optimizing cyanobacterial product synthesis: Meeting the challenges},
url = {http://dx.doi.org/10.1080/21655979.2016.1207017},
volume = {7},
year = {2016}
}
TY - JOUR
ID - 1408455
AU - Zavřel, Tomáš - Červený, Jan - Knoop, Henning - Steuer, Ralf
PY - 2016
TI - Optimizing cyanobacterial product synthesis: Meeting the challenges
JF - BIOENGINEERED
VL - 7
IS - 6
SP - 490-496
EP - 490-496
PB - TAYLOR & FRANCIS INC
SN - 21655979
KW - biofuels
KW - biotechnology
KW - cyanobacteria
KW - ethylene
KW - genome-scale models (GSM)
KW - MIMS
KW - photobioreactors
KW - systems biology
UR - http://dx.doi.org/10.1080/21655979.2016.1207017
L2 - http://dx.doi.org/10.1080/21655979.2016.1207017
N2 - The synthesis of renewable bioproducts using photosynthetic microorganisms holds great promise. Sustainable industrial applications, however, are still scarce and the true limits of phototrophic production remain unknown. One of the limitations of further progress is our insufficient understanding of the quantitative changes in photoautotrophic metabolism that occur during growth in dynamic environments. We argue that a proper evaluation of the intra- and extracellular factors that limit phototrophic production requires the use of highly-controlled cultivation in photobioreactors, coupled to real-time analysis of production parameters and their evaluation by predictive computational models. In this addendum, we discuss the importance and challenges of systems biology approaches for the optimization of renewable biofuels production. As a case study, we present the utilization of a state-of-the-art experimental setup together with a stoichiometric computational model of cyanobacterial metabolism for quantitative evaluation of ethylene production by a recombinant cyanobacterium Synechocystis sp. PCC 6803.
ER -
ZAVŘEL, Tomáš, Jan ČERVENÝ, Henning KNOOP a Ralf STEUER. Optimizing cyanobacterial product synthesis: Meeting the challenges. \textit{BIOENGINEERED}. PHILADELPHIA: TAYLOR \&{}amp; FRANCIS INC, 2016, roč.~7, č.~6, s.~490-496. ISSN~2165-5979. Dostupné z: https://dx.doi.org/10.1080/21655979.2016.1207017.
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