Evolutionarily Distant Streptophyta Respond Differently to
Genotoxic Stress

J 2017

Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress

VAGNEROVA, R., A. LUKESOVA, M. LUKES, P. ROZNOVSKA, M. HOLA et. al.

Basic information

Original name

Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress

Authors

VAGNEROVA, R. (203 Czech Republic), A. LUKESOVA (203 Czech Republic), M. LUKES (203 Czech Republic), P. ROZNOVSKA (203 Czech Republic), M. HOLA (203 Czech Republic), J. FULNECKOVA (203 Czech Republic), Jiří FAJKUS (203 Czech Republic, guarantor, belonging to the institution) and K.J. ANGELIS (203 Czech Republic)

Edition

GENES, BASEL, MDPI AG, 2017, 2073-4425

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10603 Genetics and heredity

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.191

RIV identification code

RIV/00216224:14740/17:00095507

Organization unit

Central European Institute of Technology

DOI

http://dx.doi.org/10.3390/genes8110331

UT WoS

000416800600041

Keywords in English

Physcomitrella patens; Klebsormidium; Zygnema; DNA damage and repair; bleomycin; methyl methanesulfonate; ultraviolet light

Abstract

V originále

Research in algae usually focuses on the description and characterization of morphoand phenotype as a result of adaptation to a particular habitat and its conditions. To better understand the evolution of lineages we characterized responses of filamentous streptophyte green algae of the genera Klebsormidium and Zygnema, and of a land plantthe moss Physcomitrella patensto genotoxic stress that might be relevant to their environment. We studied the induction and repair of DNA double strand breaks (DSBs) elicited by the radiomimetic drug bleomycin, DNA single strand breaks (SSB) as consequence of base modification by the alkylation agent methyl methanesulfonate (MMS) and of ultra violet (UV)-induced photo-dimers, because the mode of action of these three genotoxic agents is well understood. We show that the Klebsormidium and Physcomitrella are similarly sensitive to introduced DNA lesions and have similar rates of DSBs repair. In contrast, less DNA damage and higher repair rate of DSBs was detected in Zygnema, suggesting different mechanisms of maintaining genome integrity in response to genotoxic stress. Nevertheless, contrary to fewer detected lesions is Zygnema more sensitive to genotoxic treatment than Klebsormidium and Physcomitrella

Links

GA16-01137S, research and development project

Name: Faktory genomové stability u mechu a vyšších rostlin

Investor: Czech Science Foundation

LQ1601, research and development project

Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

VAGNEROVA, R., A. LUKESOVA, M. LUKES, P. ROZNOVSKA, M. HOLA, J. FULNECKOVA, Jiří FAJKUS and K.J. ANGELIS. Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. GENES. BASEL: MDPI AG, 2017, vol. 8, No 11, p. nestránkováno, 13 pp. ISSN 2073-4425. Available from: https://dx.doi.org/10.3390/genes8110331.

@article{1408645,
   author = {Vagnerova, R. and Lukesova, A. and Lukes, M. and Roznovska, P. and Hola, M. and Fulneckova, J. and Fajkus, Jiří and Angelis, K.J.},
   article_location = {BASEL},
   article_number = {11},
   doi = {http://dx.doi.org/10.3390/genes8110331},
   keywords = {Physcomitrella patens; Klebsormidium; Zygnema; DNA damage and repair; bleomycin; methyl methanesulfonate; ultraviolet light},
   language = {eng},
   issn = {2073-4425},
   journal = {GENES},
   title = {Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress},
   url = {http://www.mdpi.com/2073-4425/8/11/331},
   volume = {8},
   year = {2017}
}

TY  - JOUR
ID  - 1408645
AU  - Vagnerova, R. - Lukesova, A. - Lukes, M. - Roznovska, P. - Hola, M. - Fulneckova, J. - Fajkus, Jiří - Angelis, K.J.
PY  - 2017
TI  - Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress
JF  - GENES
VL  - 8
IS  - 11
SP  - nestránkováno
EP  - nestránkováno
PB  - MDPI AG
SN  - 20734425
KW  - Physcomitrella patens
KW  - Klebsormidium
KW  - Zygnema
KW  - DNA damage and repair
KW  - bleomycin
KW  - methyl methanesulfonate
KW  - ultraviolet light
UR  - http://www.mdpi.com/2073-4425/8/11/331
N2  - Research in algae usually focuses on the description and characterization of morphoand phenotype as a result of adaptation to a particular habitat and its conditions. To better understand the evolution of lineages we characterized responses of filamentous streptophyte green algae of the genera Klebsormidium and Zygnema, and of a land plantthe moss Physcomitrella patensto genotoxic stress that might be relevant to their environment. We studied the induction and repair of DNA double strand breaks (DSBs) elicited by the radiomimetic drug bleomycin, DNA single strand breaks (SSB) as consequence of base modification by the alkylation agent methyl methanesulfonate (MMS) and of ultra violet (UV)-induced photo-dimers, because the mode of action of these three genotoxic agents is well understood. We show that the Klebsormidium and Physcomitrella are similarly sensitive to introduced DNA lesions and have similar rates of DSBs repair. In contrast, less DNA damage and higher repair rate of DSBs was detected in Zygnema, suggesting different mechanisms of maintaining genome integrity in response to genotoxic stress. Nevertheless, contrary to fewer detected lesions is Zygnema more sensitive to genotoxic treatment than Klebsormidium and Physcomitrella
ER  -

VAGNEROVA, R., A. LUKESOVA, M. LUKES, P. ROZNOVSKA, M. HOLA, J. FULNECKOVA, Jiří FAJKUS and K.J. ANGELIS. Evolutionarily Distant Streptophyta Respond Differently to Genotoxic Stress. \textit{GENES}. BASEL: MDPI AG, 2017, vol.~8, No~11, p.~nestránkováno, 13 pp. ISSN~2073-4425. Available from: https://dx.doi.org/10.3390/genes8110331.

Detailed Information on Publication Record