Striato-cortical Connections in Parkinson's and Alzheimer's
Diseases: Relation to Cognition

J 2017

Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition

ANDERKOVÁ, Ľubomíra, Marek BARTOŇ a Irena REKTOROVÁ

Základní údaje

Originální název

Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition

Autoři

ANDERKOVÁ, Ľubomíra (703 Slovensko, domácí), Marek BARTOŇ (203 Česká republika, domácí) a Irena REKTOROVÁ (203 Česká republika, garant, domácí)

Vydání

Movement Disorders, HOBOKEN, WILEY, 2017, 0885-3185

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

30210 Clinical neurology

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Impakt faktor

Impact factor: 8.324

Kód RIV

RIV/00216224:14110/17:00095707

Organizační jednotka

Lékařská fakulta

DOI

http://dx.doi.org/10.1002/mds.26956

UT WoS

000402969400017

Klíčová slova anglicky

striatum; Parkinson's disease; Alzheimer's disease; resting state functional connectivity; cognition

Štítky

CF MAFIL, EL OK

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 18. 4. 2018 12:02, Soňa Böhmová

Anotace

V originále

Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. (C) 2017 International Parkinson and Movement Disorder Society

Návaznosti

LM2015062, projekt VaV

Název: Národní infrastruktura pro biologické a medicínské zobrazování

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, National research infrastructure for biological and medical imaging

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

NV15-33854A, projekt VaV

Název: Efekt intenzivní tanečně-pohybové intervence na kognitivní funkce a změny mozkové plasticity zdravých seniorů a pacientů s mírnou kognitivní poruchou

Citovat

ANDERKOVÁ, Ľubomíra, Marek BARTOŇ a Irena REKTOROVÁ. Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. Movement Disorders. HOBOKEN: WILEY, 2017, roč. 32, č. 6, s. 917-921, 7 s. ISSN 0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.26956.

@article{1408660,
   author = {Anderková, Ľubomíra and Bartoň, Marek and Rektorová, Irena},
   article_location = {HOBOKEN},
   article_number = {6},
   doi = {http://dx.doi.org/10.1002/mds.26956},
   keywords = {striatum; Parkinson's disease; Alzheimer's disease; resting state functional connectivity; cognition},
   language = {eng},
   issn = {0885-3185},
   journal = {Movement Disorders},
   title = {Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1408660
AU  - Anderková, Ľubomíra - Bartoň, Marek - Rektorová, Irena
PY  - 2017
TI  - Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition
JF  - Movement Disorders
VL  - 32
IS  - 6
SP  - 917-921
EP  - 917-921
PB  - WILEY
SN  - 08853185
KW  - striatum
KW  - Parkinson's disease
KW  - Alzheimer's disease
KW  - resting state functional connectivity
KW  - cognition
N2  - Background: Functional connectivity is abnormal in PD and in early Alzheimer's disease. Objectives: The objective of this study was to evaluate resting-state striato-cortical connectivity in PD and Alzheimer's disease and assess their relation to cognitive outcomes. Groups with mild cognitive impairment as a result of different pathologies (PD vs. Alzheimer's disease) were also compared. Methods: Seed-based connectivity of the dorsal, middle, and ventral striatum was analyzed in 111 patients using functional MRI. The correlation between connectivity at regions of between-group differences and clinical outcomes was assessed. Results: Patients showed lower striatal connectivity than controls. Connectivity between the middle (associative) striatum and precuneus negatively correlated with executive functions in PD and with memory performance in Alzheimer's disease. PD with cognitive impairment showed decreased connectivity of the dorsal (motor) striatum when compared with early Alzheimer's disease. Conclusions: Striatal connectivity was reduced in patients when compared with controls. Similar compensatory mechanisms were employed to overcome various cognitive deficits in PD and Alzheimer's disease. (C) 2017 International Parkinson and Movement Disorder Society
ER  -

ANDERKOVÁ, Ľubomíra, Marek BARTOŇ a Irena REKTOROVÁ. Striato-cortical Connections in Parkinson's and Alzheimer's Diseases: Relation to Cognition. \textit{Movement Disorders}. HOBOKEN: WILEY, 2017, roč.~32, č.~6, s.~917-921, 7 s. ISSN~0885-3185. Dostupné z: https://dx.doi.org/10.1002/mds.26956.

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