New probabilistic risk assessment of ethylhexyl
methoxycinnamate: Comparing the genotoxic effects of trans- and
cis-EHMC

J 2017

New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC

SHARMA, Anežka, Katarína BÁNYIOVÁ, Jaromír LITERÁK a Pavel ČUPR

Základní údaje

Originální název

New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC

Autoři

SHARMA, Anežka (203 Česká republika, domácí), Katarína BÁNYIOVÁ (703 Slovensko, domácí), Jaromír LITERÁK (203 Česká republika, domácí) a Pavel ČUPR (203 Česká republika, garant, domácí)

Vydání

Environmental toxicology, Hoboken, USA, WILEY-BLACKWELL, 2017, 1520-4081

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10503 Water resources

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.491

Kód RIV

RIV/00216224:14310/17:00095508

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1002/tox.22260

UT WoS

000393799500019

Klíčová slova anglicky

ethylhexyl methoxycinnamate; trans/cis isomerisation; genotoxicity; probabilistic risk assessment; QIVIVE

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 9. 4. 2018 16:26, Ing. Nicole Zrilić

Anotace

V originále

Ethylhexyl methoxycinnamate (EHMC) is a widely used UV filter present in a large number of personal care products (PCPs). Under normal conditions, EHMC occurs in a mixture of two isomers: trans-EHMC and cis-EHMC in a ratio of 99:1. When exposed to sunlight, the trans isomer is transformed to the less stable cis isomer and the efficiency of the UV filter is reduced. To date, the toxicological effects of the cis-EHMC isomer remain largely unknown. We developed a completely new method for preparing cis-EHMC. An EHMC technical mixture was irradiated using a UV lamp and 98% pure cis-EHMC was isolated from the irradiated solution using column chromatography. The genotoxic effects of the isolated cis-EHMC isomer and the nonirradiated trans-EHMC were subsequently measured using two bioassays (SOS chromotest and UmuC test). In the case of trans-EHMC, significant genotoxicity was observed using both bioassays at the highest concentrations (0.5 - 4 mgmL(-1)). In the case of cis-EHMC, significant genotoxicity was only detected using the UmuC test at concentrations of 0.25 - 1 mgmL(-1). Based on these results, the NOEC was calculated for both cis- and trans-EHMC, 0.038 and 0.064 mgmL(-1), respectively. Risk assessment of dermal, oral and inhalation exposure to PCPs containing EHMC was carried out for a female population using probabilistic simulation and by using Quantitative in vitro to in vivo extrapolation (QIVIVE). The risk of cis-EHMC was found to be approximate to 1.7 times greater than trans-EHMC. In the case of cis-EHMC, a hazard index of 1 was exceeded in the 92nd percentile. Based on the observed differences between the isomers, EHMC application in PCPs requires detailed reassessment. Further exploration of the toxicological effects and properties of cis-EHMC is needed in order to correctly predict risks posed to humans and the environment.

Návaznosti

GA14-27941S, projekt VaV

Název: Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici

Investor: Grantová agentura ČR, Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LO1214, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Centrum pro výzkum toxických látek v prostředí

Citovat

SHARMA, Anežka, Katarína BÁNYIOVÁ, Jaromír LITERÁK a Pavel ČUPR. New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC. Environmental toxicology. Hoboken, USA: WILEY-BLACKWELL, 2017, roč. 32, č. 2, s. 569-580. ISSN 1520-4081. Dostupné z: https://dx.doi.org/10.1002/tox.22260.

@article{1408672,
   author = {Sharma, Anežka and Bányiová, Katarína and Literák, Jaromír and Čupr, Pavel},
   article_location = {Hoboken, USA},
   article_number = {2},
   doi = {http://dx.doi.org/10.1002/tox.22260},
   keywords = {ethylhexyl methoxycinnamate; trans/cis isomerisation; genotoxicity; probabilistic risk assessment; QIVIVE},
   language = {eng},
   issn = {1520-4081},
   journal = {Environmental toxicology},
   title = {New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC},
   url = {http://onlinelibrary.wiley.com/doi/10.1002/tox.22260/abstract},
   volume = {32},
   year = {2017}
}

TY  - JOUR
ID  - 1408672
AU  - Sharma, Anežka - Bányiová, Katarína - Literák, Jaromír - Čupr, Pavel
PY  - 2017
TI  - New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC
JF  - Environmental toxicology
VL  - 32
IS  - 2
SP  - 569-580
EP  - 569-580
PB  - WILEY-BLACKWELL
SN  - 15204081
KW  - ethylhexyl methoxycinnamate
KW  - trans/cis isomerisation
KW  - genotoxicity
KW  - probabilistic risk assessment
KW  - QIVIVE
UR  - http://onlinelibrary.wiley.com/doi/10.1002/tox.22260/abstract
L2  - http://onlinelibrary.wiley.com/doi/10.1002/tox.22260/abstract
N2  - Ethylhexyl methoxycinnamate (EHMC) is a widely used UV filter present in a large number of personal care products (PCPs). Under normal conditions, EHMC occurs in a mixture of two isomers: trans-EHMC and cis-EHMC in a ratio of 99:1. When exposed to sunlight, the trans isomer is transformed to the less stable cis isomer and the efficiency of the UV filter is reduced. To date, the toxicological effects of the cis-EHMC isomer remain largely unknown. We developed a completely new method for preparing cis-EHMC. An EHMC technical mixture was irradiated using a UV lamp and 98% pure cis-EHMC was isolated from the irradiated solution using column chromatography. The genotoxic effects of the isolated cis-EHMC isomer and the nonirradiated trans-EHMC were subsequently measured using two bioassays (SOS chromotest and UmuC test). In the case of trans-EHMC, significant genotoxicity was observed using both bioassays at the highest concentrations (0.5 - 4 mgmL(-1)). In the case of cis-EHMC, significant genotoxicity was only detected using the UmuC test at concentrations of 0.25 - 1 mgmL(-1). Based on these results, the NOEC was calculated for both cis- and trans-EHMC, 0.038 and 0.064 mgmL(-1), respectively. Risk assessment of dermal, oral and inhalation exposure to PCPs containing EHMC was carried out for a female population using probabilistic simulation and by using Quantitative in vitro to in vivo extrapolation (QIVIVE). The risk of cis-EHMC was found to be approximate to 1.7 times greater than trans-EHMC. In the case of cis-EHMC, a hazard index of 1 was exceeded in the 92nd percentile. Based on the observed differences between the isomers, EHMC application in PCPs requires detailed reassessment. Further exploration of the toxicological effects and properties of cis-EHMC is needed in order to correctly predict risks posed to humans and the environment.
ER  -

SHARMA, Anežka, Katarína BÁNYIOVÁ, Jaromír LITERÁK a Pavel ČUPR. New probabilistic risk assessment of ethylhexyl methoxycinnamate: Comparing the genotoxic effects of trans- and cis-EHMC. \textit{Environmental toxicology}. Hoboken, USA: WILEY-BLACKWELL, 2017, roč.~32, č.~2, s.~569-580. ISSN~1520-4081. Dostupné z: https://dx.doi.org/10.1002/tox.22260.

Podrobný výpis o publikaci