Investigation of cis-trans isomer dependent
dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate
through stratum corneum in vivo

J 2017

Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo

SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN, Pavel ČUPR et. al.

Základní údaje

Originální název

Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo

Autoři

SHARMA, Anežka (203 Česká republika, domácí), Katarína BÁNYIOVÁ (703 Slovensko, domácí), Branislav VRANA (703 Slovensko, domácí), Ivan JUSTAN (203 Česká republika) a Pavel ČUPR (203 Česká republika, garant, domácí)

Vydání

Environmental Science and Pollution Research, HEIDELBERG, GERMANY, SPRINGER HEIDELBERG, 2017, 0944-1344

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10511 Environmental sciences

Stát vydavatele

Německo

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 2.800

Kód RIV

RIV/00216224:14310/17:00095511

Organizační jednotka

Přírodovědecká fakulta

DOI

http://dx.doi.org/10.1007/s11356-017-0172-2

UT WoS

000414958700026

Klíčová slova anglicky

Ethylhexyl methoxycinnamate; Personal care products; Cis/trans isomerization; Tape stripping; Dermatotoxicokinetics; Human skin permeation

Štítky

NZ, rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 5. 4. 2018 15:36, Ing. Nicole Zrilić

Anotace

V originále

2-Ethylhexyl methoxycinnamate (EHMC) is one of the most used ultraviolet filters in personal care products. It undergoes cis/trans isomerization in sunlight, and there is limited toxicological understanding of the effects of the cis-isomer. It is known that two geometric isomers of one compound can have different physico-chemical properties and effects. However, there are no studies focusing on toxicokinetics of EHMC isomerization products to compare their potential difference in dermal exposure to cis-EHMC and trans-EHMC due to the difference in their dermatotoxicokinetics. In this study, dermal absorption of the parental trans-EHMC and its cis isomer was studied. A commercially available sunscreen lotion containing trans-EHMC and spiked with laboratory-prepared cis-EHMC was locally applied on the forearm skin of two volunteers. After 8 h of skin exposure, the stratum corneum (SC) layer was removed by tape stripping. The removed thickness of the SC was determined spectrophotometrically using a total protein assay. The concentration of both isomers in the removed SC was measured by HPLC-DAD. A new diffusion and permeability coefficient of both EHMC isomers in SC were determined by Fick's second law of diffusion in vivo. The difference in dermatotoxicokinetic parameters between the two isomers was not statistically significant. However, separate toxicological studies of isomeric forms and the determination of their dermatotoxicokinetic parameters are crucial for refinement of human risk assessment.

Návaznosti

GA14-27941S, projekt VaV

Název: Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici

Investor: Grantová agentura ČR, Kinetika perkutánní penetrace optických izomerů filtrů ultrafialového záření, bromovaných retardérů hoření a polárních pesticidů při dermální expozici

LM2015051, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX RI)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Výzkumná infrastruktura RECETOX

LO1214, projekt VaV

Název: Centrum pro výzkum toxických látek v prostředí (Akronym: RECETOX)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Centrum pro výzkum toxických látek v prostředí

Citovat

SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN a Pavel ČUPR. Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo. Environmental Science and Pollution Research. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2017, roč. 24, č. 32, s. 25061-25070. ISSN 0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-017-0172-2.

@article{1408677,
   author = {Sharma, Anežka and Bányiová, Katarína and Vrana, Branislav and Justan, Ivan and Čupr, Pavel},
   article_location = {HEIDELBERG, GERMANY},
   article_number = {32},
   doi = {http://dx.doi.org/10.1007/s11356-017-0172-2},
   keywords = {Ethylhexyl methoxycinnamate; Personal care products; Cis/trans isomerization; Tape stripping; Dermatotoxicokinetics; Human skin permeation},
   language = {eng},
   issn = {0944-1344},
   journal = {Environmental Science and Pollution Research},
   title = {Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo},
   url = {https://link.springer.com/article/10.1007%2Fs11356-017-0172-2},
   volume = {24},
   year = {2017}
}

TY  - JOUR
ID  - 1408677
AU  - Sharma, Anežka - Bányiová, Katarína - Vrana, Branislav - Justan, Ivan - Čupr, Pavel
PY  - 2017
TI  - Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo
JF  - Environmental Science and Pollution Research
VL  - 24
IS  - 32
SP  - 25061-25070
EP  - 25061-25070
PB  - SPRINGER HEIDELBERG
SN  - 09441344
KW  - Ethylhexyl methoxycinnamate
KW  - Personal care products
KW  - Cis/trans isomerization
KW  - Tape stripping
KW  - Dermatotoxicokinetics
KW  - Human skin permeation
UR  - https://link.springer.com/article/10.1007%2Fs11356-017-0172-2
L2  - https://link.springer.com/article/10.1007%2Fs11356-017-0172-2
N2  - 2-Ethylhexyl methoxycinnamate (EHMC) is one of the most used ultraviolet filters in personal care products. It undergoes cis/trans isomerization in sunlight, and there is limited toxicological understanding of the effects of the cis-isomer. It is known that two geometric isomers of one compound can have different physico-chemical properties and effects. However, there are no studies focusing on toxicokinetics of EHMC isomerization products to compare their potential difference in dermal exposure to cis-EHMC and trans-EHMC due to the difference in their dermatotoxicokinetics. In this study, dermal absorption of the parental trans-EHMC and its cis isomer was studied. A commercially available sunscreen lotion containing trans-EHMC and spiked with laboratory-prepared cis-EHMC was locally applied on the forearm skin of two volunteers. After 8 h of skin exposure, the stratum corneum (SC) layer was removed by tape stripping. The removed thickness of the SC was determined spectrophotometrically using a total protein assay. The concentration of both isomers in the removed SC was measured by HPLC-DAD. A new diffusion and permeability coefficient of both EHMC isomers in SC were determined by Fick's second law of diffusion in vivo. The difference in dermatotoxicokinetic parameters between the two isomers was not statistically significant. However, separate toxicological studies of isomeric forms and the determination of their dermatotoxicokinetic parameters are crucial for refinement of human risk assessment.
ER  -

SHARMA, Anežka, Katarína BÁNYIOVÁ, Branislav VRANA, Ivan JUSTAN a Pavel ČUPR. Investigation of cis-trans isomer dependent dermatotoxicokinetics of UV filter ethylhexyl methoxycinnamate through stratum corneum in vivo. \textit{Environmental Science and Pollution Research}. HEIDELBERG, GERMANY: SPRINGER HEIDELBERG, 2017, roč.~24, č.~32, s.~25061-25070. ISSN~0944-1344. Dostupné z: https://dx.doi.org/10.1007/s11356-017-0172-2.

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