TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR, Robert VÁCHA a Mikael LUND. Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. Langmuir. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, roč. 34, č. 4, s. 1266-1273. ISSN 0743-7463. Dostupné z: https://dx.doi.org/10.1021/acs.langmuir.7b03155. |
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@article{1409325, author = {Tesei, Giulio and Hellstrand, Erik and Sanagavarapu, Kalyani and Linse, Sara and Sparr, Emma and Vácha, Robert and Lund, Mikael}, article_location = {WASHINGTON}, article_number = {4}, doi = {http://dx.doi.org/10.1021/acs.langmuir.7b03155}, keywords = {QUARTZ-CRYSTAL MICROBALANCE; ATOMIC-RESOLUTION STRUCTURE; POISSON-BOLTZMANN THEORY; AIR-WATER-INTERFACE; ALPHA-SYNUCLEIN; MONTE-CARLO; STRUCTURAL BASIS; LIPID-MEMBRANES; BETA-PEPTIDE; FIBRILS}, language = {eng}, issn = {0743-7463}, journal = {Langmuir}, title = {Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces}, url = {https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155}, volume = {34}, year = {2018} }
TY - JOUR ID - 1409325 AU - Tesei, Giulio - Hellstrand, Erik - Sanagavarapu, Kalyani - Linse, Sara - Sparr, Emma - Vácha, Robert - Lund, Mikael PY - 2018 TI - Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces JF - Langmuir VL - 34 IS - 4 SP - 1266-1273 EP - 1266-1273 PB - AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA SN - 07437463 KW - QUARTZ-CRYSTAL MICROBALANCE KW - ATOMIC-RESOLUTION STRUCTURE KW - POISSON-BOLTZMANN THEORY KW - AIR-WATER-INTERFACE KW - ALPHA-SYNUCLEIN KW - MONTE-CARLO KW - STRUCTURAL BASIS KW - LIPID-MEMBRANES KW - BETA-PEPTIDE KW - FIBRILS UR - https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155 N2 - Amyloid aggregates are associated with a range of human neuro-degenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface. ER -
TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR, Robert VÁCHA a Mikael LUND. Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. \textit{Langmuir}. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, roč.~34, č.~4, s.~1266-1273. ISSN~0743-7463. Dostupné z: https://dx.doi.org/10.1021/acs.langmuir.7b03155.
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