Aggregate Size Dependence of Amyloid Adsorption onto Charged
Interfaces

J 2018

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces

TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR et. al.

Základní údaje

Originální název

Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces

Autoři

TESEI, Giulio (752 Švédsko), Erik HELLSTRAND (752 Švédsko), Kalyani SANAGAVARAPU (752 Švédsko), Sara LINSE (752 Švédsko), Emma SPARR (752 Švédsko), Robert VÁCHA (203 Česká republika, garant, domácí) a Mikael LUND (752 Švédsko)

Vydání

Langmuir, WASHINGTON, AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, 0743-7463

Další údaje

Jazyk

angličtina

Typ výsledku

Článek v odborném periodiku

Obor

10400 1.4 Chemical sciences

Stát vydavatele

Spojené státy

Utajení

není předmětem státního či obchodního tajemství

Odkazy

URL

Impakt faktor

Impact factor: 3.683

Kód RIV

RIV/00216224:14740/18:00100839

Organizační jednotka

Středoevropský technologický institut

DOI

http://dx.doi.org/10.1021/acs.langmuir.7b03155

UT WoS

000424070400005

Klíčová slova anglicky

QUARTZ-CRYSTAL MICROBALANCE; ATOMIC-RESOLUTION STRUCTURE; POISSON-BOLTZMANN THEORY; AIR-WATER-INTERFACE; ALPHA-SYNUCLEIN; MONTE-CARLO; STRUCTURAL BASIS; LIPID-MEMBRANES; BETA-PEPTIDE; FIBRILS

Štítky

rivok

Příznaky

Mezinárodní význam, Recenzováno

Změněno: 21. 3. 2019 09:47, Mgr. Pavla Foltynová, Ph.D.

Anotace

V originále

Amyloid aggregates are associated with a range of human neuro-degenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface.

Návaznosti

ED3.2.00/08.0144, projekt VaV

Název: CERIT Scientific Cloud

GA14-12598S, projekt VaV

Název: Samouspořádané systémy amfifilních peptiů (Akronym: SAAP)

Investor: Grantová agentura ČR, Self-assembly of amphiphilic peptides with helical character

LM2010005, projekt VaV

Název: Velká infrastruktura CESNET (Akronym: VI CESNET)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, Velká infrastruktura CESNET

LQ1601, projekt VaV

Název: CEITEC 2020 (Akronym: CEITEC2020)

Investor: Ministerstvo školství, mládeže a tělovýchovy ČR, CEITEC 2020

Citovat

TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR, Robert VÁCHA a Mikael LUND. Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. Langmuir. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, roč. 34, č. 4, s. 1266-1273. ISSN 0743-7463. Dostupné z: https://dx.doi.org/10.1021/acs.langmuir.7b03155.

@article{1409325,
   author = {Tesei, Giulio and Hellstrand, Erik and Sanagavarapu, Kalyani and Linse, Sara and Sparr, Emma and Vácha, Robert and Lund, Mikael},
   article_location = {WASHINGTON},
   article_number = {4},
   doi = {http://dx.doi.org/10.1021/acs.langmuir.7b03155},
   keywords = {QUARTZ-CRYSTAL MICROBALANCE; ATOMIC-RESOLUTION STRUCTURE; POISSON-BOLTZMANN THEORY; AIR-WATER-INTERFACE; ALPHA-SYNUCLEIN; MONTE-CARLO; STRUCTURAL BASIS; LIPID-MEMBRANES; BETA-PEPTIDE; FIBRILS},
   language = {eng},
   issn = {0743-7463},
   journal = {Langmuir},
   title = {Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces},
   url = {https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155},
   volume = {34},
   year = {2018}
}

TY  - JOUR
ID  - 1409325
AU  - Tesei, Giulio - Hellstrand, Erik - Sanagavarapu, Kalyani - Linse, Sara - Sparr, Emma - Vácha, Robert - Lund, Mikael
PY  - 2018
TI  - Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces
JF  - Langmuir
VL  - 34
IS  - 4
SP  - 1266-1273
EP  - 1266-1273
PB  - AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN  - 07437463
KW  - QUARTZ-CRYSTAL MICROBALANCE
KW  - ATOMIC-RESOLUTION STRUCTURE
KW  - POISSON-BOLTZMANN THEORY
KW  - AIR-WATER-INTERFACE
KW  - ALPHA-SYNUCLEIN
KW  - MONTE-CARLO
KW  - STRUCTURAL BASIS
KW  - LIPID-MEMBRANES
KW  - BETA-PEPTIDE
KW  - FIBRILS
UR  - https://pubs.acs.org/doi/10.1021/acs.langmuir.7b03155
N2  - Amyloid aggregates are associated with a range of human neuro-degenerative disorders, and it has been shown that neurotoxicity is dependent on aggregate size. Combining molecular simulation with analytical theory, a predictive model is proposed for the adsorption of amyloid aggregates onto oppositely charged surfaces, where the interaction is governed by an interplay between electrostatic attraction and entropic repulsion. Predictions are experimentally validated against quartz crystal microbalance-dissipation experiments of amyloid beta peptides and fragmented fibrils in the presence of a supported lipid bilayer. Assuming amyloids as rigid, elongated particles, we observe nonmonotonic trends for the extent of adsorption with respect to aggregate size and preferential adsorption of smaller aggregates over larger ones. Our findings describe a general phenomenon with implications for stiff polyions and rodlike particles that are electrostatically attracted to a surface.
ER  -

TESEI, Giulio, Erik HELLSTRAND, Kalyani SANAGAVARAPU, Sara LINSE, Emma SPARR, Robert VÁCHA a Mikael LUND. Aggregate Size Dependence of Amyloid Adsorption onto Charged Interfaces. \textit{Langmuir}. WASHINGTON: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA, 2018, roč.~34, č.~4, s.~1266-1273. ISSN~0743-7463. Dostupné z: https://dx.doi.org/10.1021/acs.langmuir.7b03155.

Podrobný výpis o publikaci